The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.

by Gang Li, Pierre Cunin, Di Wu, Dorothée Diogo, Yu Yang, Yukinori Okada, Robert M Plenge, Peter A Nigrovic
Published 2016-09-01

Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset.

by Lori B Chibnik, Brendan T Keenan, Jing Cui, Katherine P Liao, Karen H Costenbader, Robert M Plenge, Elizabeth W Karlson
Published 2011-01-01

Defining the role of the MHC in autoimmunity: a review and pooled analysis.

by Michelle M A Fernando, Christine R Stevens, Emily C Walsh, Philip L De Jager, Philippe Goyette, Robert M Plenge, Timothy J Vyse, John D Rioux
Published 2008-04-01

Analysis and application of European genetic substructure using 300 K SNP information.

by Chao Tian, Robert M Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Selmi, Lars Klareskog, Ann E Pulver, Lihong Qi, Peter K Gregersen, Michael F Seldin
Published 2008-01-01

Quantifying missing heritability at known GWAS loci.

by Alexander Gusev, Gaurav Bhatia, Noah Zaitlen, Bjarni J Vilhjalmsson, Dorothée Diogo, Eli A Stahl, Peter K Gregersen, Jane Worthington, Lars Klareskog, Soumya Raychaudhuri, Robert M Plenge, Bogdan Pasaniuc, Alkes L Price
Published 2013-01-01

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

by Soumya Raychaudhuri, Robert M Plenge, Elizabeth J Rossin, Aylwin C Y Ng, International Schizophrenia Consortium, Shaun M Purcell, Pamela Sklar, Edward M Scolnick, Ramnik J Xavier, David Altshuler, Mark J Daly
Published 2009-06-01

Automatic prediction of rheumatoid arthritis disease activity from the electronic medical records.

by Chen Lin, Elizabeth W Karlson, Helena Canhao, Helena Canhao, Timothy A Miller, Dmitriy Dligach, Pei Jun Chen, Raul Natanael Guzman Perez, Yuanyan Shen, Michael E Weinblatt, Nancy A Shadick, Robert M Plenge, Guergana K Savova
Published 2013-01-01

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.

by Paul L Klarenbeek, Marieke E Doorenspleet, Rebecca E E Esveldt, Barbera D C van Schaik, Neubury Lardy, Antoine H C van Kampen, Paul P Tak, Robert M Plenge, Frank Baas, Paul I W de Bakker, Niek de Vries
Published 2015-01-01

Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients.

by Soha R Dargham, Sumeja Zahirovic, Mohammed Hammoudeh, Samar Al Emadi, Basel K Masri, Hussein Halabi, Humeira Badsha, Imad Uthman, Ziyad R Mahfoud, Hadil Ashour, Wissam Gad El Haq, Karim Bayoumy, Marianthi Kapiri, Richa Saxena, Robert M Plenge, Layla Kazkaz, Thurayya Arayssi
Published 2018-01-01

Correction: Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients.

by Soha R Dargham, Sumeja Zahirovic, Mohammed Hammoudeh, Samar Al Emadi, Basel K Masri, Hussein Halabi, Humeira Badsha, Imad Uthman, Ziyad R Mahfoud, Hadil Ashour, Wissam Gad El Haq, Karim Bayoumy, Marianthi Kapiri, Richa Saxena, Robert M Plenge, Layla Kazkaz, Thurayya Arayssi
Published 2019-01-01

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.

by Edwin Choy, Roman Yelensky, Sasha Bonakdar, Robert M Plenge, Richa Saxena, Philip L De Jager, Stanley Y Shaw, Cara S Wolfish, Jacqueline M Slavik, Chris Cotsapas, Manuel Rivas, Emmanouil T Dermitzakis, Ellen Cahir-McFarland, Elliott Kieff, David Hafler, Mark J Daly, David Altshuler
Published 2008-11-01

Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts.

by Katherine P Liao, Ashwin N Ananthakrishnan, Vishesh Kumar, Zongqi Xia, Andrew Cagan, Vivian S Gainer, Sergey Goryachev, Pei Chen, Guergana K Savova, Denis Agniel, Susanne Churchill, Jaeyoung Lee, Shawn N Murphy, Robert M Plenge, Peter Szolovits, Isaac Kohane, Stanley Y Shaw, Elizabeth W Karlson, Tianxi Cai
Published 2015-01-01

Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.

by Kimberly E Taylor, Elaine F Remmers, Annette T Lee, Ward A Ortmann, Robert M Plenge, Chao Tian, Sharon A Chung, Joanne Nititham, Geoffrey Hom, Amy H Kao, F Yesim Demirci, M Ilyas Kamboh, Michelle Petri, Susan Manzi, Daniel L Kastner, Michael F Seldin, Peter K Gregersen, Timothy W Behrens, Lindsey A Criswell
Published 2008-05-01

Modeling disease severity in multiple sclerosis using electronic health records.

by Zongqi Xia, Elizabeth Secor, Lori B Chibnik, Riley M Bove, Suchun Cheng, Tanuja Chitnis, Andrew Cagan, Vivian S Gainer, Pei J Chen, Katherine P Liao, Stanley Y Shaw, Ashwin N Ananthakrishnan, Peter Szolovits, Howard L Weiner, Elizabeth W Karlson, Shawn N Murphy, Guergana K Savova, Tianxi Cai, Susanne E Churchill, Robert M Plenge, Isaac S Kohane, Philip L De Jager
Published 2013-01-01

A Role for Noncoding Variation in Schizophrenia

by Panos Roussos, Amanda C. Mitchell, Georgios Voloudakis, John F. Fullard, Venu M. Pothula, Jonathan Tsang, Eli A. Stahl, Anastasios Georgakopoulos, Douglas M. Ruderfer, Alexander Charney, Yukinori Okada, Katherine A. Siminovitch, Jane Worthington, Leonid Padyukov, Lars Klareskog, Peter K. Gregersen, Robert M. Plenge, Soumya Raychaudhuri, Menachem Fromer, Shaun M. Purcell, Kristen J. Brennand, Nikolaos K. Robakis, Eric E. Schadt, Schahram Akbarian, Pamela Sklar
Published 2014-11-01

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.

by Gang Li, Dorothée Diogo, Di Wu, Jim Spoonamore, Vlado Dancik, Lude Franke, Fina Kurreeman, Elizabeth J Rossin, Grant Duclos, Cathy Hartland, Xuezhong Zhou, Kejie Li, Jun Liu, Philip L De Jager, Katherine A Siminovitch, Alexandra Zhernakova, Soumya Raychaudhuri, John Bowes, Steve Eyre, Leonid Padyukov, Peter K Gregersen, Jane Worthington, Rheumatoid Arthritis Consortium International (RACI), Namrata Gupta, Paul A Clemons, Eli Stahl, Nicola Tolliday, Robert M Plenge
Published 2013-05-01

TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy

by Helena Canhão, Ana Maria Rodrigues, Maria José Santos, Diana Carmona-Fernandes, Bruno F. Bettencourt, Jing Cui, Fabiana L. Rocha, José Canas Silva, Joaquim Polido-Pereira, José Alberto Pereira Silva, José António Costa, Domingos Araujo, Cândida Silva, Helena Santos, Cátia Duarte, Rafael Cáliz, Ileana Filipescu, Fernando Pimentel-Santos, Jaime Branco, Juan Sainz, Robert M. Plenge, Daniel H. Solomon, Jácome Bruges-Armas, José António P. Da Silva, João Eurico Fonseca, Elizabeth W. Karlson
Published 2015-01-01

Phenome-wide association studies across large population cohorts support drug target validation

by Dorothée Diogo, Chao Tian, Christopher S. Franklin, Mervi Alanne-Kinnunen, Michael March, Chris C. A. Spencer, Ciara Vangjeli, Michael E. Weale, Hannele Mattsson, Elina Kilpeläinen, Patrick M. A. Sleiman, Dermot F. Reilly, Joshua McElwee, Joseph C. Maranville, Arnaub K. Chatterjee, Aman Bhandari, Khanh-Dung H. Nguyen, Karol Estrada, Mary-Pat Reeve, Janna Hutz, Nan Bing, Sally John, Daniel G. MacArthur, Veikko Salomaa, Samuli Ripatti, Hakon Hakonarson, Mark J. Daly, Aarno Palotie, David A. Hinds, Peter Donnelly, Caroline S. Fox, Aaron G. Day-Williams, Robert M. Plenge, Heiko Runz
Published 2018-10-01

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.

by Alexandra Zhernakova, Eli A Stahl, Gosia Trynka, Soumya Raychaudhuri, Eleanora A Festen, Lude Franke, Harm-Jan Westra, Rudolf S N Fehrmann, Fina A S Kurreeman, Brian Thomson, Namrata Gupta, Jihane Romanos, Ross McManus, Anthony W Ryan, Graham Turner, Elisabeth Brouwer, Marcel D Posthumus, Elaine F Remmers, Francesca Tucci, Rene Toes, Elvira Grandone, Maria Cristina Mazzilli, Anna Rybak, Bozena Cukrowska, Marieke J H Coenen, Timothy R D J Radstake, Piet L C M van Riel, Yonghong Li, Paul I W de Bakker, Peter K Gregersen, Jane Worthington, Katherine A Siminovitch, Lars Klareskog, Tom W J Huizinga, Cisca Wijmenga, Robert M Plenge
Published 2011-02-01

Informed conditioning on clinical covariates increases power in case-control association studies.

by Noah Zaitlen, Sara Lindström, Bogdan Pasaniuc, Marilyn Cornelis, Giulio Genovese, Samuela Pollack, Anne Barton, Heike Bickeböller, Donald W Bowden, Steve Eyre, Barry I Freedman, David J Friedman, John K Field, Leif Groop, Aage Haugen, Joachim Heinrich, Brian E Henderson, Pamela J Hicks, Lynne J Hocking, Laurence N Kolonel, Maria Teresa Landi, Carl D Langefeld, Loic Le Marchand, Michael Meister, Ann W Morgan, Olaide Y Raji, Angela Risch, Albert Rosenberger, David Scherf, Sophia Steer, Martin Walshaw, Kevin M Waters, Anthony G Wilson, Paul Wordsworth, Shanbeh Zienolddiny, Eric Tchetgen Tchetgen, Christopher Haiman, David J Hunter, Robert M Plenge, Jane Worthington, David C Christiani, Debra A Schaumberg, Daniel I Chasman, David Altshuler, Benjamin Voight, Peter Kraft, Nick Patterson, Alkes L Price
Published 2012-01-01