Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at <i>IKZF1</i> and <i>IKZF3</i> in Systemic Lupus Erythematosus

by Timothy J. Vyse, Deborah S. Cunninghame Graham
Published 2020-11-01

Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease.

by Christopher A Odhams, Deborah S Cunninghame Graham, Timothy J Vyse
Published 2017-10-01

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.

by Lora Boteva, IMAGEN, Yee Ling Wu, Josefina Cortes-Hernández, Javier Martin, Timothy J Vyse, Michelle M A Fernando
Published 2011-01-01

A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: implications for clinical interpretation.

by Benjamin Rhodes, Marilyn E Merriman, Andrew Harrison, Michael J Nissen, Malcolm Smith, Lisa Stamp, Sophia Steer, Tony R Merriman, Timothy J Vyse
Published 2010-09-01

Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice.

by Anne E Bygrave, Kirsten L Rose, Josefina Cortes-Hernandez, Joanna Warren, Robert J Rigby, H Terence Cook, Mark J Walport, Timothy J Vyse, Marina Botto
Published 2004-08-01

Defining the role of the MHC in autoimmunity: a review and pooled analysis.

by Michelle M A Fernando, Christine R Stevens, Emily C Walsh, Philip L De Jager, Philippe Goyette, Robert M Plenge, Timothy J Vyse, John D Rioux
Published 2008-04-01

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.

by Deborah S Cunninghame Graham, David L Morris, Tushar R Bhangale, Lindsey A Criswell, Ann-Christine Syvänen, Lars Rönnblom, Timothy W Behrens, Robert R Graham, Timothy J Vyse
Published 2011-10-01

Identification of two independent risk factors for lupus within the MHC in United Kingdom families.

by Michelle M A Fernando, Christine R Stevens, Pardis C Sabeti, Emily C Walsh, Alasdair J M McWhinnie, Anila Shah, Todd Green, John D Rioux, Timothy J Vyse
Published 2007-11-01

Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE

by Huoru Zhang, Yan Zhang, Yong-Fei Wang, David Morris, Nattiya Hirankarn, Yujun Sheng, Jiangshan Shen, Hai-Feng Pan, Jing Yang, Sen Yang, Yong Cui, Dong-Qing Ye, Timothy J. Vyse, Xuejun Zhang, Yu Lung Lau, Wanling Yang
Published 2018-05-01

Independent Replication on Genome-Wide Association Study Signals Identifies IRF3 as a Novel Locus for Systemic Lupus Erythematosus

by Feixia Zhang, Yong-Fei Wang, Yong-Fei Wang, Yan Zhang, Zhiming Lin, Yujie Cao, Huoru Zhang, Zhong-Yi Liu, David L. Morris, Yujun Sheng, Yong Cui, Xuejun Zhang, Timothy J. Vyse, Yu Lung Lau, Wanling Yang, Yanhui Chen
Published 2020-07-01

Common variants within MECP2 confer risk of systemic lupus erythematosus.

by Amr H Sawalha, Ryan Webb, Shizhong Han, Jennifer A Kelly, Kenneth M Kaufman, Robert P Kimberly, Marta E Alarcón-Riquelme, Judith A James, Timothy J Vyse, Gary S Gilkeson, Chan-Bum Choi, R Hal Scofield, Sang-Cheol Bae, Swapan K Nath, John B Harley
Published 2008-03-01

Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus

by Christopher A. Odhams, Amy L. Roberts, Susan K. Vester, Carolina S. T. Duarte, Charlie T. Beales, Alexander J. Clarke, Sonja Lindinger, Samuel J. Daffern, Antonino Zito, Lingyan Chen, Leonardo L. Jones, Lora Boteva, David L. Morris, Kerrin S. Small, Michelle M. A. Fernando, Deborah S. Cunninghame Graham, Timothy J. Vyse
Published 2019-05-01

A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.

by Bruce A C Cree, John D Rioux, Jacob L McCauley, Pierre-Antoine F D Gourraud, Philippe Goyette, Joseph McElroy, Philip De Jager, Adam Santaniello, Timothy J Vyse, Peter K Gregersen, Daniel Mirel, David A Hafler, Jonathan L Haines, Margaret A Pericak-Vance, Alastair Compston, Stephen J Sawcer, Jorge R Oksenberg, Stephen L Hauser, IMAGEN, IMSGC
Published 2010-06-01

Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).

by Anna Hellquist, Marco Zucchelli, Cecilia M Lindgren, Ulpu Saarialho-Kere, Tiina M Järvinen, Sari Koskenmies, Heikki Julkunen, Päivi Onkamo, Tiina Skoog, Jaana Panelius, Anne Räisänen-Sokolowski, Taina Hasan, Elisabeth Widen, Iva Gunnarson, Elisabet Svenungsson, Leonid Padyukov, Ghazaleh Assadi, Linda Berglind, Ville-Veikko Mäkelä, Katja Kivinen, Andrew Wong, Deborah S Cunningham Graham, Timothy J Vyse, Mauro D'Amato, Juha Kere
Published 2009-12-01

A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap.

by Paula S Ramos, Lindsey A Criswell, Kathy L Moser, Mary E Comeau, Adrienne H Williams, Nicholas M Pajewski, Sharon A Chung, Robert R Graham, Raphael Zidovetzki, Jennifer A Kelly, Kenneth M Kaufman, Chaim O Jacob, Timothy J Vyse, Betty P Tsao, Robert P Kimberly, Patrick M Gaffney, Marta E Alarcón-Riquelme, John B Harley, Carl D Langefeld, International Consortium on the Genetics of Systemic Erythematosus
Published 2011-12-01

Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations.

by Ana M Valdes, Unnur Styrkarsdottir, Michael Doherty, David L Morris, Massimo Mangino, Agu Tamm, Sally A Doherty, Kalle Kisand, Irina Kerna, Ann Tamm, Margaret Wheeler, Rose A Maciewicz, Weiya Zhang, Kenneth R Muir, Elaine M Dennison, Deborah J Hart, Sarah Metrustry, Ingileif Jonsdottir, Gudbjorn F Jonsson, Helgi Jonsson, Thorvaldur Ingvarsson, Cyrus Cooper, Timothy J Vyse, Tim D Spector, Kari Stefansson, Nigel K Arden
Published 2011-01-01

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

by Yong-Fei Wang, Yan Zhang, Zhiming Lin, Huoru Zhang, Ting-You Wang, Yujie Cao, David L. Morris, Yujun Sheng, Xianyong Yin, Shi-Long Zhong, Xiaoqiong Gu, Yao Lei, Jing He, Qi Wu, Jiangshan Jane Shen, Jing Yang, Tai-Hing Lam, Jia-Huang Lin, Zhi-Ming Mai, Mengbiao Guo, Yuanjia Tang, Yanhui Chen, Qin Song, Bo Ban, Chi Chiu Mok, Yong Cui, Liangjing Lu, Nan Shen, Pak C. Sham, Chak Sing Lau, David K. Smith, Timothy J. Vyse, Xuejun Zhang, Yu Lung Lau, Wanling Yang
Published 2021-02-01

The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus

by Isaac T. W. Harley, Timothy B. Niewold, Rebecca M. Stormont, Kenneth M. Kaufman, Stuart B. Glenn, Beverly S. Franek, Jennifer A. Kelly, Jeffrey R. Kilpatrick, David Hutchings, Jasmin Divers, Gail R. Bruner, Jeffrey C. Edberg, Gerald McGwin, Michelle A. Petri, Rosalind Ramsey-Goldman, John D. Reveille, Luis M. Vilá-Pérez, Joan T. Merrill, Gary S. Gilkeson, Timothy J. Vyse, Marta E. Alarcón-Riquelme, Soo-Kyung Cho, Chaim O. Jacob, Graciela S. Alarcón, Kathy L. Moser, Patrick M. Gaffney, Robert P. Kimberly, Sang-Cheol Bae, Carl D. Langefeld, John B. Harley, Joel M. Guthridge, Judith A. James
Published 2010-01-01

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production.

by Julio E Molineros, Amit K Maiti, Celi Sun, Loren L Looger, Shizhong Han, Xana Kim-Howard, Stuart Glenn, Adam Adler, Jennifer A Kelly, Timothy B Niewold, Gary S Gilkeson, Elizabeth E Brown, Graciela S Alarcón, Jeffrey C Edberg, Michelle Petri, Rosalind Ramsey-Goldman, John D Reveille, Luis M Vilá, Barry I Freedman, Betty P Tsao, Lindsey A Criswell, Chaim O Jacob, Jason H Moore, Timothy J Vyse, Carl L Langefeld, Joel M Guthridge, Patrick M Gaffney, Kathy L Moser, R Hal Scofield, Marta E Alarcón-Riquelme, BIOLUPUS Network, Scott M Williams, Joan T Merrill, Judith A James, Kenneth M Kaufman, Robert P Kimberly, John B Harley, Swapan K Nath
Published 2013-01-01

MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus.

by Yun Deng, Jian Zhao, Daisuke Sakurai, Kenneth M Kaufman, Jeffrey C Edberg, Robert P Kimberly, Diane L Kamen, Gary S Gilkeson, Chaim O Jacob, R Hal Scofield, Carl D Langefeld, Jennifer A Kelly, Rosalind Ramsey-Goldman, Michelle A Petri, John D Reveille, Luis M Vilá, Graciela S Alarcón, Timothy J Vyse, Bernardo A Pons-Estel, Argentine Collaborative Group, Barry I Freedman, Patrick M Gaffney, Kathy Moser Sivils, Judith A James, Peter K Gregersen, Juan-Manuel Anaya, Timothy B Niewold, Joan T Merrill, Lindsey A Criswell, Anne M Stevens, Susan A Boackle, Rita M Cantor, Weiling Chen, Jeniffer M Grossman, Bevra H Hahn, John B Harley, Marta E Alarcόn-Riquelme, BIOLUPUS and GENLES networks, Elizabeth E Brown, Betty P Tsao
Published 2013-01-01