Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites

by Freinkman, Elizaveta, Chen, Walter W., Sabatini, David
Published 2018

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

by Freinkman, Elizaveta, Birsoy, Kıvanç, Chen, Walter W., Wang, Tim, Sabatini, David
Published 2018

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

by Freinkman, Elizaveta, Wang, Tim, Chen, Walter W., Abu-Remaileh, Monther, Sabatini, David, Birsoy, Kivanc
Published 2017

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

by Yu, Haiyan, Hughes, Nicholas W., Kendirli, Arek, Klein, Klara, Lander, Eric S., Wang, Tim, Liu, Bingxu, Chen, Walter W., Sabatini, David
Published 2018

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient

by Freinkman, Elizaveta, Wyant, Gregory Andrew, Abu-Remaileh, Monther, Wolfson, Rachel Laura, Chen, Walter W., Danai, Laura V, Vander Heiden, Matthew G., Sabatini, David
Published 2018

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

by Chen, Walter W., Marjanovic, Nemanja, Zoncu, Roberto, Katajisto, Pekka, Dohla, Julia, Chaffer, Christine L., Pentinmikko, Nalle, Iqbal, Sharif, Weinberg, Robert A, Sabatini, David
Published 2015

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

by Possemato, Richard, Lorbeer, Franziska K., Bayraktar, Erol C., Thiru, Prathapan, Yucel, Burcu, Wang, Tim, Chen, Walter W., Clish, Clary, Wang, Tim, Birsoy, Kivanc, Sabatini, David
Published 2015

Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells

by Chen, Walter W., Mihaylova, Maria M., Snitkin, Harriet, Stasinski, Iwona, Yucel, Burcu, Bayraktar, Erol C., Carette, Jan E., Clish, Clary, Brummelkamp, Thijn R., Sabatini, David M, Birsoy, Kivanc
Published 2015

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

by Bar-Peled, Liron, Chantranupong, Lynne, Cherniack, Andrew D., Chen, Walter W., Ottina, Kathleen, Grabiner, Brian C., Spear, Eric D., Carter, Scott L., Meyerson, Matthew L., Sabatini, David M.
Published 2014

MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo

by Bayraktar, Erol C., Baudrier, Lou, Özerdem, Ceren, Lewis, Caroline A., Chan, Sze Ham, Kunchok, Tenzin, Abu-Remaileh, Monther, Cangelosi, Andrew L., Sabatini, David M., Birsoy, Kıvanç, Chen, Walter W.
Published 2020

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

by Birsoy, Kivanc, Wang, Tim, Possemato, Richard, Koch, Catherine E., Chen, Walter W., Hutchins, Amanda W., Gultekin, Yetis, Carette, Jan E., Brummelkamp, Thijn R., Clish, Clary, Yilmaz, Omer, Peterson, Timothy Richard, Sabatini, David
Published 2013

MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme

by Li, Yingzhong, Ivica, Nikola A, Dong, Ting, Papageorgiou, Dimitrios P, He, Yanpu, Brown, Douglas R, Kleyman, Marianna, Hu, Guangan, Chen, Walter W, Sullivan, Lucas B, Del Rosario, Amanda, Hammond, Paula T, Vander Heiden, Matthew G, Chen, Jianzhu
Published 2021

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

by Freinkman, Elizaveta, Comb, William C, Cantor, Jason R, Tam, Wai Leong, Thiru, Prathapan, Kanarek, Naama, Bierie, Brian, Shaul, Yoav, Kim, Dohoon, Chen, Walter W., Possemato, Richard, Reinhardt, Ferenc, Weinberg, Robert A, Yaffe, Michael B, Sabatini, David, Pacold, Michael Edward
Published 2017

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

by Chan, Sze Ham, Lewis, Caroline, Swier, Lotteke J. Y. M., Chen, Walter W., Sullivan, Lucas Bryan, Fiske, Brian Prescott, Cho, Sung Won, Abu-Remaileh, Monther, Liu, Chieh Ming Jamin, Zhou, Minerva H., Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Vander Heiden, Matthew G., Sabatini, David, Pacold, Michael Edward
Published 2017