Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

by Saxton, Robert Andrew, Wolfson, Rachel Laura, Chantranupong, Lynne, Wang, Tim, Schwartz, Thomas, Sabatini, David, Knockenhauer, Kevin Edward, Pacold, Michael Edward
Published 2017

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

by Kang, Seong A., Cervantes, Christopher L., Lim, Daniel Cham-Chin, Ottina, Kathleen, Lou, Hua Jane, Gray, Nathanael S., Turk, Benjamin E., Pacold, Michael Edward, Yaffe, Michael B, Sabatini, David
Published 2014

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

by Rohde, Jason M., Brimacombe, Kyle R., Liu, Li, Pacold, Michael Edward, Yasgar, Adam, Cheff, Dorian M., Lee, Tobie D., Rai, Ganesha, Baljinnyam, Bolormaa, Li, Zhuyin, Simeonov, Anton, Hall, Matthew D., Shen, Min, Sabatini, David, Boxer, Matthew B.
Published 2020

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

by Freinkman, Elizaveta, Comb, William C, Cantor, Jason R, Tam, Wai Leong, Thiru, Prathapan, Kanarek, Naama, Bierie, Brian, Shaul, Yoav, Kim, Dohoon, Chen, Walter W., Possemato, Richard, Reinhardt, Ferenc, Weinberg, Robert A, Yaffe, Michael B, Sabatini, David, Pacold, Michael Edward
Published 2017

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

by Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Hahn, William C., Kory, Nora, Sabatini, David, Pacold, Michael Edward
Published 2017

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

by Chan, Sze Ham, Lewis, Caroline, Swier, Lotteke J. Y. M., Chen, Walter W., Sullivan, Lucas Bryan, Fiske, Brian Prescott, Cho, Sung Won, Abu-Remaileh, Monther, Liu, Chieh Ming Jamin, Zhou, Minerva H., Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Vander Heiden, Matthew G., Sabatini, David, Pacold, Michael Edward
Published 2017

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

by Kami, Kenjiro, Shelton, Laura M., Ramkissoon, Shakti H., Ligon, Keith L., Snuderl, Matija, Kim, Dohoon, Fiske, Brian Prescott, Birsoy, Kivanc, Freinkman, Elizaveta, Possemato, Richard, Chudnovsky, Yakov, Chen, Walter W., Cantor, Jason R., Gui, Dan Yi, Kwon, ManJae, Kang, Seong Woo, Vander Heiden, Matthew G., Sabatini, David, Pacold, Michael Edward
Published 2017

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer

by Possemato, Richard, Marks, Kevin M., Kim, Dohoon, Birsoy, Kivanc, Sethumadhavan, Shalini, Woo, Hin-Koon, Jang, Hyun G., Jha, Abhishek K., Chen, Walter W., Barrett, Francesca G., Stransky, Nicolas, Tsun, Zhi-Yang, Cowley, Glenn S., Barretina, Jordi, Kalaany, Nada Y., Hsu, Peggy P., Ottina, Kathleen, Chan, Albert M., Yuan, Bingbing B., Garraway, Levi A., Root, David E., Mino-Kenudson, Mari, Brachtel, Elena F., Driggers, Edward M., Shaul, Yoav, Pacold, Michael Edward, Sabatini, David
Published 2012