Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

by Chan, Sze Ham, Freinkman, Elizaveta, Abu-Remaileh, Monther, Wyant, Gregory Andrew, Kim, Choah, Laqtom, Nouf N, Abbasi, Maria, Sabatini, David
Published 2019

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient

by Freinkman, Elizaveta, Wyant, Gregory Andrew, Abu-Remaileh, Monther, Wolfson, Rachel Laura, Chen, Walter W., Danai, Laura V, Vander Heiden, Matthew G., Sabatini, David
Published 2018

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

by Gygi, Melanie P., Shen, Kuang, Harper, J. Wade, Gygi, Steven P., Chantranupong, Lynne, Scaria, Sonia M., Saxton, Robert Andrew, Wyant, Gregory Andrew, Wang, Tim, Sabatini, David
Published 2017

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

by Shen, Kuang, Petri, Sabrina, Abu-Remaileh, Monther, Frankel, Wayne N., Wolfson, Rachel Laura, Chantranupong, Lynne, Wyant, Gregory Andrew, Gu, Xin, Orozco Segrera, Jose, Condon, Kendall Janine, Kedir, Jibril Fetu, Scaria, Sonia M., Sabatini, David
Published 2018

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

by Plovanich, M. E., Straub, C., Sabatini, B. L., Tsun, Zhi-Yang, Wang, Shuyu, Wolfson, Rachel Laura, Shen, Kuang, Wyant, Gregory Andrew, Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William C., Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Kim, Choah, Park, Jiwon, Sabatini, David
Published 2015