A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

by Grabiner, Brian C., Nardi, Valentina, Birsoy, Kivanc, Possemato, Richard, Shen, Kuang, Sinha, Sumi, Jordan, Alexander, Beck, Andrew H., Sabatini, David
Published 2015

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

by Ersching, Jonatan, Efeyan, Alejo, Mesin, Luka, Jacobsen, Johanne T., Pasqual, Giulia, Grabiner, Brian C., Dominguez-Sola, David, Victora, Gabriel D., Sabatini, David
Published 2018

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

by Bar-Peled, Liron, Chantranupong, Lynne, Cherniack, Andrew D., Chen, Walter W., Ottina, Kathleen, Grabiner, Brian C., Spear, Eric D., Carter, Scott L., Meyerson, Matthew L., Sabatini, David M.
Published 2014

Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib

by Wagle, N., Grabiner, Brian C., Van Allen, E. M., Hodis, Eran, Jacobus, S., Supko, J. G., Stewart, M., Choueiri, T. K., Gandhi, L., Cleary, J. M., Elfiky, A. A., Taplin, M. E., Stack, E. C., Signoretti, S., Loda, Massimo, Shapiro, G. I., Gabriel, Stacey B., Kantoff, Philip W., Garraway, Levi A., Rosenberg, J. E., Sabatini, David, Lander, Eric Steven
Published 2015