The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

by Wolfson, Rachel Laura, Sabatini, David
Published 2018

Nutrient-Sensing Mechanisms across Evolution

by Chantranupong, Lynne, Wolfson, Rachel Laura, Sabatini, David
Published 2016

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

by Sabatini, David, Wolfson, Rachel Laura, Efeyan, Alejo
Published 2017

Sestrin2 is a leucine sensor for the mTORC1 pathway

by Shen, K., Cantor, J. R., Wolfson, Rachel Laura, Chantranupong, Lynne, Saxton, Robert Andrew, Scaria, Sonia M., Sabatini, David
Published 2017

Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival

by Efeyan, Alejo, Zoncu, Roberto, Chang, Steven, Gumper, Iwona, Snitkin, Harriet, Kirak, Oktay, Sabatini, David D., Wolfson, Rachel Laura, Sabatini, David
Published 2015

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

by Saxton, Robert Andrew, Wolfson, Rachel Laura, Chantranupong, Lynne, Wang, Tim, Schwartz, Thomas, Sabatini, David, Knockenhauer, Kevin Edward, Pacold, Michael Edward
Published 2017

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient

by Freinkman, Elizaveta, Wyant, Gregory Andrew, Abu-Remaileh, Monther, Wolfson, Rachel Laura, Chen, Walter W., Danai, Laura V, Vander Heiden, Matthew G., Sabatini, David
Published 2018

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

by Chantranupong, Lynne, Orozco, Jose M, Scaria, Sonia M, Bar-Peled, Liron, Spooner, Eric, Isasa, Marta, Gygi, Steven P., Sabatini, David M, Wolfson, Rachel Laura, Saxton, Robert Andrew, Scaria, Sonia M., Sabatini, David
Published 2015

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

by Shen, Kuang, Petri, Sabrina, Abu-Remaileh, Monther, Frankel, Wayne N., Wolfson, Rachel Laura, Chantranupong, Lynne, Wyant, Gregory Andrew, Gu, Xin, Orozco Segrera, Jose, Condon, Kendall Janine, Kedir, Jibril Fetu, Scaria, Sonia M., Sabatini, David
Published 2018

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

by Plovanich, M. E., Straub, C., Sabatini, B. L., Tsun, Zhi-Yang, Wang, Shuyu, Wolfson, Rachel Laura, Shen, Kuang, Wyant, Gregory Andrew, Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William C., Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Kim, Choah, Park, Jiwon, Sabatini, David
Published 2015