Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer

by Anna S Trigos, Richard B Pearson, Anthony T Papenfuss, David L Goode
Published 2019-02-01

Therapeutic Approaches Targeting MYC-Driven Prostate Cancer

by Richard J. Rebello, Richard B. Pearson, Ross D. Hannan, Luc Furic
Published 2017-02-01

Cystathionine β-Synthase in Physiology and Cancer

by Haoran Zhu, Shaun Blake, Keefe T. Chan, Richard B. Pearson, Jian Kang
Published 2018-01-01

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy

by Jian Kang, Natalie Brajanovski, Keefe T. Chan, Jiachen Xuan, Richard B. Pearson, Elaine Sanij
Published 2021-08-01

rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

by Jinbae Son, Jinbae Son, Katherine M. Hannan, Katherine M. Hannan, Gretchen Poortinga, Gretchen Poortinga, Gretchen Poortinga, Nadine Hein, Donald P. Cameron, Austen R. D. Ganley, Karen E. Sheppard, Karen E. Sheppard, Karen E. Sheppard, Richard B. Pearson, Richard B. Pearson, Richard B. Pearson, Richard B. Pearson, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Elaine Sanij, Elaine Sanij, Elaine Sanij
Published 2020-07-01

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

by Shunfei Yan, Daniel Frank, Jinbae Son, Katherine M. Hannan, Ross D. Hannan, Keefe T. Chan, Richard B. Pearson, Elaine Sanij
Published 2017-01-01

Exploring Perspectives on Antimicrobial Use in Livestock: A Mixed-Methods Study of UK Pig Farmers

by Lucy A. Coyne, Sophia M. Latham, Susan Dawson, Ian J. Donald, Richard B. Pearson, Rob F. Smith, Nicola J. Williams, Gina L. Pinchbeck
Published 2019-08-01

Drosophila ribosomal protein mutants control tissue growth non-autonomously via effects on the prothoracic gland and ecdysone.

by Jane I Lin, Naomi C Mitchell, Marina Kalcina, Elly Tchoubrieva, Mary J Stewart, Steven J Marygold, Cherryl D Walker, George Thomas, Sally J Leevers, Richard B Pearson, Leonie M Quinn, Ross D Hannan
Published 2011-12-01

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells.

by Jeannine Diesch, Elaine Sanij, Omer Gilan, Christopher Love, Hoanh Tran, Nicholas I Fleming, Jason Ellul, Marcia Amalia, Izhak Haviv, Richard B Pearson, Eugene Tulchinsky, John M Mariadason, Oliver M Sieber, Ross D Hannan, Amardeep S Dhillon
Published 2014-01-01

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.

by Åslaug Helland, Michael S Anglesio, Joshy George, Prue A Cowin, Cameron N Johnstone, Colin M House, Karen E Sheppard, Dariush Etemadmoghadam, Nataliya Melnyk, Anil K Rustgi, Wayne A Phillips, Hilde Johnsen, Ruth Holm, Gunnar B Kristensen, Michael J Birrer, Australian Ovarian Cancer Study Group, Richard B Pearson, Anne-Lise Børresen-Dale, David G Huntsman, Anna deFazio, Chad J Creighton, Gordon K Smyth, David D L Bowtell
Published 2011-04-01

Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis.

by Yeliz Boglev, Andrew P Badrock, Andrew J Trotter, Qian Du, Elsbeth J Richardson, Adam C Parslow, Sebastian J Markmiller, Nathan E Hall, Tanya A de Jong-Curtain, Annie Y Ng, Heather Verkade, Elke A Ober, Holly A Field, Donghun Shin, Chong H Shin, Katherine M Hannan, Ross D Hannan, Richard B Pearson, Seok-Hyung Kim, Kevin C Ess, Graham J Lieschke, Didier Y R Stainier, Joan K Heath
Published 2013-01-01

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

by Elaine Sanij, Katherine M. Hannan, Jiachen Xuan, Shunfei Yan, Jessica E. Ahern, Anna S. Trigos, Natalie Brajanovski, Jinbae Son, Keefe T. Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J. Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J. Deans, Kum Kum Khanna, Linda Mileshkin, Grant A. McArthur, John Soong, Els M. J. J. Berns, Ross D. Hannan, Clare L. Scott, Karen E. Sheppard, Richard B. Pearson
Published 2020-05-01

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

by Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann, Kevin K. Lin, Thomas C. Harding, Nadia Traficante, Australian Ovarian Cancer Study (AOCS), Anna deFazio, Iain A. McNeish, David D. Bowtell, Elizabeth M. Swisher, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott
Published 2018-09-01