Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin

by Seok-Hyung Kim, Christina K. Speirs, Lilianna Solnica-Krezel, Kevin C. Ess
Published 2011-03-01

Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin

by Robert P. Carson, Dominic L. Van Nielen, Peggy A. Winzenburger, Kevin C. Ess
Published 2012-01-01

Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish

by Seok-Hyung Kim, Marie L. Kowalski, Robert P. Carson, L. Richard Bridges, Kevin C. Ess
Published 2013-07-01

Reproducible and efficient generation of functionally active neurons from human hiPSCs for preclinical disease modeling

by Yunyao Xie, Ryan J. Schutte, Nathan N. Ng, Kevin C. Ess, Philip H. Schwartz, Diane K. O'Dowd
Published 2018-01-01

Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency.

by Seok-Hyung Kim, Sarah A Scott, Michael J Bennett, Robert P Carson, Joshua Fessel, H Alex Brown, Kevin C Ess
Published 2013-06-01

Gammaretroviral vector encoding a fluorescent marker to facilitate detection of reprogrammed human fibroblasts during iPSC generation

by Narasimhachar Srinivasakumar, Michail Zaboikin, Andrew M. Tidball, Asad A. Aboud, M. Diana Neely, Kevin C. Ess, Aaron B. Bowman, Friedrich G. Schuening
Published 2013-12-01

Cerebral aquaporin-4 expression is independent of seizures in tuberous sclerosis complex

by Brittany Short, Lindsay Kozek, Hannah Harmsen, Bo Zhang, Michael Wong, Kevin C. Ess, Cary Fu, Robert Naftel, Matthew M. Pearson, Robert P. Carson
Published 2019-09-01

Comparisons of dual isogenic human iPSC pairs identify functional alterations directly caused by an epilepsy associated SCN1A mutation

by Yunyao Xie, Nathan N. Ng, Olga S. Safrina, Carmen M. Ramos, Kevin C. Ess, Philip H. Schwartz, Martin A. Smith, Diane K. O'Dowd
Published 2020-02-01

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood

by Christine Q. Simmons, Christopher H. Thompson, Bryan E. Cawthon, Grant Westlake, Kathryn J. Swoboda, Evangelos Kiskinis, Kevin C. Ess, Alfred L. George, Jr
Published 2018-07-01

Neuronal modeling of alternating hemiplegia of childhood reveals transcriptional compensation and replicates a trigger-induced phenotype

by John P. Snow, Grant Westlake, Lindsay K. Klofas, Soyoun Jeon, Laura C. Armstrong, Kathryn J. Swoboda, Alfred L. George, Jr, Kevin C. Ess
Published 2020-07-01

DEPDC5 haploinsufficiency drives increased mTORC1 signaling and abnormal morphology in human iPSC-derived cortical neurons

by Lindsay K. Klofas, Brittany P. Short, John P. Snow, Justine Sinnaeve, Gabrielle V. Rushing, Grant Westlake, Will Weinstein, Rebecca A. Ihrie, Kevin C. Ess, Robert P. Carson
Published 2020-09-01

Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells.

by Andrew M Tidball, M Diana Neely, Reed Chamberlin, Asad A Aboud, Kevin K Kumar, Bingying Han, Miles R Bryan, Michael Aschner, Kevin C Ess, Aaron B Bowman
Published 2016-01-01

Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination.

by Mark D Grier, Kathryn L West, Nathaniel D Kelm, Cary Fu, Mark D Does, Brittany Parker, Eleanor McBrier, Andre H Lagrange, Kevin C Ess, Robert P Carson
Published 2017-01-01

PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper

by Asad A. Aboud, Andrew M. Tidball, Kevin K. Kumar, M. Diana Neely, Bingying Han, Kevin C. Ess, Charles C. Hong, Keith M. Erikson, Peter Hedera, Aaron B. Bowman
Published 2015-01-01

Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex

by Ling-Hui Zeng, Yannan Ouyang, Vered Gazit, John R. Cirrito, Laura A. Jansen, Kevin C. Ess, Kelvin A. Yamada, David F. Wozniak, David M. Holtzman, David H. Gutmann, Michael Wong
Published 2007-11-01

A Simplified, Fully Defined Differentiation Scheme for Producing Blood-Brain Barrier Endothelial Cells from Human iPSCs

by Emma H. Neal, Nicholas A. Marinelli, Yajuan Shi, P. Mason McClatchey, Kylie M. Balotin, Dalton R. Gullett, Kameron A. Hagerla, Aaron B. Bowman, Kevin C. Ess, John P. Wikswo, Ethan S. Lippmann
Published 2019-06-01

A post-developmental genetic screen for zebrafish models of inherited liver disease.

by Seok-Hyung Kim, Shu-Yu Wu, Jeong-In Baek, Soo Young Choi, Yanhui Su, Charles R Flynn, Joshua T Gamse, Kevin C Ess, Gary Hardiman, Joshua H Lipschutz, Naji N Abumrad, Don C Rockey
Published 2015-01-01

Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis.

by Yeliz Boglev, Andrew P Badrock, Andrew J Trotter, Qian Du, Elsbeth J Richardson, Adam C Parslow, Sebastian J Markmiller, Nathan E Hall, Tanya A de Jong-Curtain, Annie Y Ng, Heather Verkade, Elke A Ober, Holly A Field, Donghun Shin, Chong H Shin, Katherine M Hannan, Ross D Hannan, Richard B Pearson, Seok-Hyung Kim, Kevin C Ess, Graham J Lieschke, Didier Y R Stainier, Joan K Heath
Published 2013-01-01

Genetic Variation in the Voltage-gated Potassium Channel Genes KCNV2 and KCNB1 Contributes to Epilepsy Susceptibility

by Jorge, Benjamin S.
Published 2014