Mouse Models for Exploring the Biological Consequences and Clinical Significance of <i>PIK3CA</i> Mutations

by Camilla B. Mitchell, Wayne A. Phillips
Published 2019-04-01

Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells

by Meredith J. Layton, Natalie K. Rynkiewicz, Ivan Ivetac, Kristy A. Horan, Christina A. Mitchell, Wayne A. Phillips
Published 2014-04-01

Transketolase regulates sensitivity to APR-246 in p53-null cells independently of oxidative stress modulation

by Julia V. Milne, Bonnie Z. Zhang, Kenji M. Fujihara, Swati Dawar, Wayne A. Phillips, Nicholas J. Clemons
Published 2021-02-01

Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.

by Anjali Tikoo, Vincent Roh, Karen G Montgomery, Ivan Ivetac, Paul Waring, Rebecca Pelzer, Lauren Hare, Mark Shackleton, Patrick Humbert, Wayne A Phillips
Published 2012-01-01

Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett’s EsophagusSummary

by Jovana R. Gotovac, Tanjina Kader, Julia V. Milne, Kenji M. Fujihara, Luis E. Lara-Gonzalez, Kylie L. Gorringe, Sangeetha N. Kalimuthu, Madawa W. Jayawardana, Cuong P. Duong, Wayne A. Phillips, Nicholas J. Clemons
Published 2021-01-01

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

by David S. Liu, Cuong P. Duong, Sue Haupt, Karen G. Montgomery, Colin M. House, Walid J. Azar, Helen B. Pearson, Oliver M. Fisher, Matthew Read, Glen R. Guerra, Ygal Haupt, Carleen Cullinane, Klas G. Wiman, Lars Abrahmsen, Wayne A. Phillips, Nicholas J. Clemons
Published 2017-03-01

HOXA13 in etiology and oncogenic potential of Barrett’s esophagus

by Vincent T. Janmaat, Kateryna Nesteruk, Manon C. W. Spaander, Auke P. Verhaar, Bingting Yu, Rodrigo A. Silva, Wayne A. Phillips, Marcin Magierowski, Anouk van de Winkel, H. Scott Stadler, Tatiana Sandoval-Guzmán, Luc J. W. van der Laan, Ernst J. Kuipers, Ron Smits, Marco J. Bruno, Gwenny M. Fuhler, Nicholas J. Clemons, Maikel P. Peppelenbosch
Published 2021-06-01

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

by Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo, Wayne Pearce, Nicholas McGranahan, Sally M. Dewhurst, Valerie Meniel, Nicolai J. Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria E. R. Parker, Karen G. Montgomery, Larissa S. Moniz, Cheryl L. Scudamore, Wayne A. Phillips, Robert K. Semple, Alan Clarke, Charles Swanton, Bart Vanhaesebroeck
Published 2017-11-01

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.

by Åslaug Helland, Michael S Anglesio, Joshy George, Prue A Cowin, Cameron N Johnstone, Colin M House, Karen E Sheppard, Dariush Etemadmoghadam, Nataliya Melnyk, Anil K Rustgi, Wayne A Phillips, Hilde Johnsen, Ruth Holm, Gunnar B Kristensen, Michael J Birrer, Australian Ovarian Cancer Study Group, Richard B Pearson, Anne-Lise Børresen-Dale, David G Huntsman, Anna deFazio, Chad J Creighton, Gordon K Smyth, David D L Bowtell
Published 2011-04-01