Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma

by Emily J. Lelliott, Emily J. Lelliott, Grant A. McArthur, Grant A. McArthur, Jane Oliaro, Jane Oliaro, Jane Oliaro, Karen E. Sheppard, Karen E. Sheppard, Karen E. Sheppard
Published 2021-05-01

Obesity and the Impact on Cutaneous Melanoma: Friend or Foe?

by Lorey K. Smith, Shaghayegh Arabi, Emily J. Lelliott, Grant A. McArthur, Karen E. Sheppard
Published 2020-06-01

CDK4/6 Inhibition Reprograms Mitochondrial Metabolism in BRAF^V600 Melanoma via a p53 Dependent Pathway

by Nancy T. Santiappillai, Shatha Abuhammad, Alison Slater, Laura Kirby, Grant A. McArthur, Karen E Sheppard, Lorey K Smith
Published 2021-01-01

rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

by Jinbae Son, Jinbae Son, Katherine M. Hannan, Katherine M. Hannan, Gretchen Poortinga, Gretchen Poortinga, Gretchen Poortinga, Nadine Hein, Donald P. Cameron, Austen R. D. Ganley, Karen E. Sheppard, Karen E. Sheppard, Karen E. Sheppard, Richard B. Pearson, Richard B. Pearson, Richard B. Pearson, Richard B. Pearson, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Elaine Sanij, Elaine Sanij, Elaine Sanij
Published 2020-07-01

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.

by Åslaug Helland, Michael S Anglesio, Joshy George, Prue A Cowin, Cameron N Johnstone, Colin M House, Karen E Sheppard, Dariush Etemadmoghadam, Nataliya Melnyk, Anil K Rustgi, Wayne A Phillips, Hilde Johnsen, Ruth Holm, Gunnar B Kristensen, Michael J Birrer, Australian Ovarian Cancer Study Group, Richard B Pearson, Anne-Lise Børresen-Dale, David G Huntsman, Anna deFazio, Chad J Creighton, Gordon K Smyth, David D L Bowtell
Published 2011-04-01

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

by Elaine Sanij, Katherine M. Hannan, Jiachen Xuan, Shunfei Yan, Jessica E. Ahern, Anna S. Trigos, Natalie Brajanovski, Jinbae Son, Keefe T. Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J. Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J. Deans, Kum Kum Khanna, Linda Mileshkin, Grant A. McArthur, John Soong, Els M. J. J. Berns, Ross D. Hannan, Clare L. Scott, Karen E. Sheppard, Richard B. Pearson
Published 2020-05-01