Potential Importance of Early Focal Radiotherapy Following Gross Total Resection for Long-Term Survival in Children With Embryonal Tumors With Multilayered Rosettes

by Lisa Mayr, Johannes Gojo, Andreas Peyrl, Amedeo A. Azizi, Natalia M. Stepien, Thomas Pletschko, Thomas Czech, Christian Dorfer, Sander Lambo, Sander Lambo, Karin Dieckmann, Christine Haberler, Marcel Kool, Marcel Kool, Marcel Kool, Irene Slavc
Published 2020-12-01

Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma.

by Jens Bunt, Nancy E Hasselt, Danny A Zwijnenburg, Jan Koster, Rogier Versteeg, Marcel Kool
Published 2011-01-01

Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth

by Cecilia Dyberg, Teodora Andonova, Thale Kristin Olsen, Bertha Brodin, Marcel Kool, Per Kogner, John Inge Johnsen, Malin Wickström
Published 2019-12-01

Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells.

by Jonathan P Robson, Marc Remke, Marcel Kool, Elaine Julian, Andrey Korshunov, Stefan M Pfister, Geoffrey W Osborne, Michael D Taylor, Brandon Wainwright, Brent A Reynolds
Published 2019-01-01

Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.

by Catherine Vaillant, Paola Valdivieso, Sandro Nuciforo, Marcel Kool, Alexandra Schwarzentruber-Schauerte, Hélène Méreau, Erik Cabuy, Johannes A Lobrinus, Stefan Pfister, Aimée Zuniga, Stephan Frank, Rolf Zeller
Published 2015-01-01

Coverage bias and sensitivity of variant calling for four whole-genome sequencing technologies.

by Nora Rieber, Marc Zapatka, Bärbel Lasitschka, David Jones, Paul Northcott, Barbara Hutter, Natalie Jäger, Marcel Kool, Michael Taylor, Peter Lichter, Stefan Pfister, Stephan Wolf, Benedikt Brors, Roland Eils
Published 2013-01-01

Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma

by Ae Kyung Park, Ji Yeoun Lee, Heesun Cheong, Vijay Ramaswamy, Sung-Hye Park, Marcel Kool, Ji Hoon Phi, Seung Ah Choi, Florence Cavalli, Michael D. Taylor, Seung-Ki Kim
Published 2019-06-01

Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma

by Jeroen F. Vermeulen, Wim Van Hecke, Elisabeth J. M. Adriaansen, Mieke K. Jansen, Rianne G. Bouma, José Villacorta Hidalgo, Paul Fisch, Roel Broekhuizen, Wim G. M. Spliet, Marcel Kool, Niels Bovenschen
Published 2018-03-01

Epigenetic Silencing of DKK3 in Medulloblastoma

by André Oberthuer, Giuseppe Cinalli, Tiziana Servidei, Massimo Zollo, Thomas Hielscher, Massimo Romani, Claudio Brigati, Alfa H.C. Bai, Marc Remke, Marcel Kool, Stefano Moretti, Stefan M. Pfister, Sara Stigliani, Barbara Banelli, Francesca Valdora, Gian Paolo Tonini, Simona Coco
Published 2013-04-01

Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

by Andrey Korshunov, Konstantin Okonechnikov, Felix Schmitt-Hoffner, Marina Ryzhova, Felix Sahm, Damian Stichel, Daniel Schrimpf, David E. Reuss, Philipp Sievers, Abigail Kora Suwala, Ella Kumirova, Olga Zheludkova, Andrey Golanov, David T. W. Jones, Stefan M. Pfister, Marcel Kool, Andreas von Deimling
Published 2021-02-01

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.

by Marcel Kool, Jan Koster, Jens Bunt, Nancy E Hasselt, Arjan Lakeman, Peter van Sluis, Dirk Troost, Netteke Schouten-van Meeteren, Huib N Caron, Jacqueline Cloos, Alan Mrsić, Bauke Ylstra, Wieslawa Grajkowska, Wolfgang Hartmann, Torsten Pietsch, David Ellison, Steven C Clifford, Rogier Versteeg
Published 2008-08-01

Downregulation of miR‐326 and its host gene β‐arrestin1 induces pro‐survival activity of E2F1 and promotes medulloblastoma growth

by Evelina Miele, Agnese Po, Angela Mastronuzzi, Andrea Carai, Zein Mersini Besharat, Natalia Pediconi, Luana Abballe, Giuseppina Catanzaro, Claudia Sabato, Enrico De Smaele, Gianluca Canettieri, Lucia Di Marcotullio, Alessandra Vacca, Antonello Mai, Massimo Levrero, Stefan M. Pfister, Marcel Kool, Felice Giangaspero, Franco Locatelli, Elisabetta Ferretti
Published 2021-02-01

Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma

by Seçkin Akgül, Yinghua Li, Siyuan Zheng, Marcel Kool, Daniel M. Treisman, Chaoyang Li, Yuan Wang, Susanne Gröbner, Tsuneo Ikenoue, Yiping Shen, Sandra Camelo-Piragua, Gerald Tomasek, Sebastian Stark, Vinay Guduguntla, James F. Gusella, Kun-Liang Guan, Stefan M. Pfister, Roel G.W. Verhaak, Yuan Zhu
Published 2018-07-01

Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors

by Camilla Calandrini, Sander R. van Hooff, Irene Paassen, Dilara Ayyildiz, Sepide Derakhshan, M. Emmy M. Dolman, Karin P.S. Langenberg, Marieke van de Ven, Cecilia de Heus, Nalan Liv, Marcel Kool, Ronald R. de Krijger, Godelieve A.M. Tytgat, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Jarno Drost
Published 2021-08-01

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis

by Paola Infante, Roberta Faedda, Flavia Bernardi, Francesca Bufalieri, Ludovica Lospinoso Severini, Romina Alfonsi, Daniela Mazzà, Mariangela Siler, Sonia Coni, Agnese Po, Marialaura Petroni, Elisabetta Ferretti, Mattia Mori, Enrico De Smaele, Gianluca Canettieri, Carlo Capalbo, Marella Maroder, Isabella Screpanti, Marcel Kool, Stefan M. Pfister, Daniele Guardavaccaro, Alberto Gulino, Lucia Di Marcotullio
Published 2018-03-01

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

by Manasi Ratnaparkhe, John K. L. Wong, Pei-Chi Wei, Mario Hlevnjak, Thorsten Kolb, Milena Simovic, Daniel Haag, Yashna Paul, Frauke Devens, Paul Northcott, David T. W. Jones, Marcel Kool, Anna Jauch, Agata Pastorczak, Wojciech Mlynarski, Andrey Korshunov, Rajiv Kumar, Susanna M. Downing, Stefan M. Pfister, Marc Zapatka, Peter J. McKinnon, Frederick W. Alt, Peter Lichter, Aurélie Ernst
Published 2018-11-01

Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

by Lars Custers, Eleonora Khabirova, Tim H. H. Coorens, Thomas R. W. Oliver, Camilla Calandrini, Matthew D. Young, Felipe A. Vieira Braga, Peter Ellis, Lira Mamanova, Heidi Segers, Arie Maat, Marcel Kool, Eelco W. Hoving, Marry M. van den Heuvel-Eibrink, James Nicholson, Karin Straathof, Liz Hook, Ronald R. de Krijger, Claire Trayers, Kieren Allinson, Sam Behjati, Jarno Drost
Published 2021-03-01

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

by Weijun Feng, Daisuke Kawauchi, Huiqin Körkel-Qu, Huan Deng, Elisabeth Serger, Laura Sieber, Jenna Ariel Lieberman, Silvia Jimeno-González, Sander Lambo, Bola S. Hanna, Yassin Harim, Malin Jansen, Anna Neuerburg, Olga Friesen, Marc Zuckermann, Vijayanad Rajendran, Jan Gronych, Olivier Ayrault, Andrey Korshunov, David T. W. Jones, Marcel Kool, Paul A. Northcott, Peter Lichter, Felipe Cortés-Ledesma, Stefan M. Pfister, Hai-Kun Liu
Published 2017-03-01

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

by Kristian W. Pajtler, Yiju Wei, Konstantin Okonechnikov, Patricia B. G. Silva, Mikaella Vouri, Lei Zhang, Sebastian Brabetz, Laura Sieber, Melissa Gulley, Monika Mauermann, Tatjana Wedig, Norman Mack, Yuka Imamura Kawasawa, Tanvi Sharma, Marc Zuckermann, Felipe Andreiuolo, Eric Holland, Kendra Maass, Huiqin Körkel-Qu, Hai-Kun Liu, Felix Sahm, David Capper, Jens Bunt, Linda J. Richards, David T. W. Jones, Andrey Korshunov, Lukas Chavez, Peter Lichter, Mikio Hoshino, Stefan M. Pfister, Marcel Kool, Wei Li, Daisuke Kawauchi
Published 2019-09-01

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration

by Hye-Jung E. Chun, Pascal D. Johann, Katy Milne, Marc Zapatka, Annette Buellesbach, Naveed Ishaque, Murat Iskar, Serap Erkek, Lisa Wei, Basile Tessier-Cloutier, Jake Lever, Emma Titmuss, James T. Topham, Reanne Bowlby, Eric Chuah, Karen L. Mungall, Yussanne Ma, Andrew J. Mungall, Richard A. Moore, Michael D. Taylor, Daniela S. Gerhard, Steven J.M. Jones, Andrey Korshunov, Manfred Gessler, Kornelius Kerl, Martin Hasselblatt, Michael C. Frühwald, Elizabeth J. Perlman, Brad H. Nelson, Stefan M. Pfister, Marco A. Marra, Marcel Kool
Published 2019-11-01