TAZ Represses the Neuronal Commitment of Neural Stem Cells

by Natalia Robledinos-Antón, Maribel Escoll, Kun-Liang Guan, Antonio Cuadrado
Published 2020-10-01

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

by Anita Parmigiani, Aida Nourbakhsh, Boxiao Ding, Wei Wang, Young Chul Kim, Konstantin Akopiants, Kun-Liang Guan, Michael Karin, Andrei V. Budanov
Published 2014-11-01

Structural insights into TSC complex assembly and GAP activity on Rheb

by Huirong Yang, Zishuo Yu, Xizi Chen, Jiabei Li, Ningning Li, Jiaxuan Cheng, Ning Gao, Hai-Xin Yuan, Dan Ye, Kun-Liang Guan, Yanhui Xu
Published 2021-01-01

LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction

by Jiong Li, Xiaohong Chen, Xiangming Ding, Yingduan Cheng, Bin Zhao, Zhi-chun Lai, Khalid Al Hezaimi, Razqallah Hakem, Kun-liang Guan, Cun-Yu Wang
Published 2020-06-01

LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction

by Jiong Li, Xiaohong Chen, Xiangming Ding, Yingduan Cheng, Bin Zhao, Zhi-chun Lai, Khalid Al Hezaimi, Razqallah Hakem, Kun-liang Guan, Cun-Yu Wang
Published 2013-12-01

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells

by Mehmet G. Badur, Thangaselvam Muthusamy, Seth J. Parker, Shenghong Ma, Samuel K. McBrayer, Thekla Cordes, Jose H. Magana, Kun-Liang Guan, Christian M. Metallo
Published 2018-10-01

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents

by Pu Wang, Jing Wu, Shenghong Ma, Lei Zhang, Jun Yao, Katherine A. Hoadley, Matthew D. Wilkerson, Charles M. Perou, Kun-Liang Guan, Dan Ye, Yue Xiong
Published 2015-12-01

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

by Jenna L Jewell, Vivian Fu, Audrey W Hong, Fa-Xing Yu, Delong Meng, Chase H Melick, Huanyu Wang, Wai-Ling Macrina Lam, Hai-Xin Yuan, Susan S Taylor, Kun-Liang Guan
Published 2019-05-01

Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1.

by Shiwen Wang, Bowen Jiang, Tengfei Zhang, Lixia Liu, Yi Wang, Yiping Wang, Xiufei Chen, Huaipeng Lin, Lisha Zhou, Yukun Xia, Leilei Chen, Chen Yang, Yue Xiong, Dan Ye, Kun-Liang Guan
Published 2015-11-01

Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1.

by Shiwen Wang, Bowen Jiang, Tengfei Zhang, Lixia Liu, Yi Wang, Yiping Wang, Xiufei Chen, Huaipeng Lin, Lisha Zhou, Yukun Xia, Leilei Chen, Chen Yang, Yue Xiong, Dan Ye, Kun-Liang Guan
Published 2015-01-01

Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

by Fu-Long Li, Jin-Ping Liu, Ruo-Xuan Bao, GuoQuan Yan, Xu Feng, Yan-Ping Xu, Yi-Ping Sun, Weili Yan, Zhi-Qiang Ling, Yue Xiong, Kun-Liang Guan, Hai-Xin Yuan
Published 2018-02-01

SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.

by Mengli Zhang, Jian Wu, Renqiang Sun, Xiaoting Tao, Xiaoxia Wang, Qi Kang, Hui Wang, Lei Zhang, Peng Liu, Jinye Zhang, Yukun Xia, Yuzheng Zhao, Yi Yang, Yue Xiong, Kun-Liang Guan, Yunzeng Zou, Dan Ye
Published 2019-01-01

Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma

by Seçkin Akgül, Yinghua Li, Siyuan Zheng, Marcel Kool, Daniel M. Treisman, Chaoyang Li, Yuan Wang, Susanne Gröbner, Tsuneo Ikenoue, Yiping Shen, Sandra Camelo-Piragua, Gerald Tomasek, Sebastian Stark, Vinay Guduguntla, James F. Gusella, Kun-Liang Guan, Stefan M. Pfister, Roel G.W. Verhaak, Yuan Zhu
Published 2018-07-01

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network

by Yu-Kun Xia, Yi-Rong Zeng, Meng-Li Zhang, Peng Liu, Fang Liu, Hao Zhang, Chen-Xi He, Yi-Ping Sun, Jin-Ye Zhang, Cheng Zhang, Lei Song, Chen Ding, Yu-Jie Tang, Zhen Yang, Chen Yang, Pu Wang, Kun-Liang Guan, Yue Xiong, Dan Ye
Published 2020-07-01

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

by Daniel Martin, Maria S. Degese, Lynn Vitale-Cross, Ramiro Iglesias-Bartolome, Juan Luis Callejas Valera, Zhiyong Wang, Xiaodong Feng, Huwate Yeerna, Vachan Vadmal, Toshiro Moroishi, Rick F. Thorne, Moraima Zaida, Bradford Siegele, Sok C. Cheong, Alfredo A. Molinolo, Yardena Samuels, Pablo Tamayo, Kun Liang Guan, Scott M. Lippman, J. Guy Lyons, J. Silvio Gutkind
Published 2018-07-01

The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming

by Zhou-Li Cheng, Meng-Li Zhang, Huai-Peng Lin, Chao Gao, Jun-Bin Song, Zhihong Zheng, Linpeng Li, Yanan Zhang, Xiaoqi Shen, Hao Zhang, Zhenghui Huang, Wuqiang Zhan, Cheng Zhang, Xu Hu, Yi-Ping Sun, Lubing Jiang, Lei Sun, Yanhui Xu, Chen Yang, Yuanlong Ge, Yong Zhao, Xingguo Liu, Hui Yang, Pengyuan Liu, Xing Guo, Kun-Liang Guan, Yue Xiong, Mingliang Zhang, Dan Ye
Published 2020-07-01

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response

by Lei-Lei Chen, Huai-Peng Lin, Wen-Jie Zhou, Chen-Xi He, Zhi-Yong Zhang, Zhou-Li Cheng, Jun-Bin Song, Peng Liu, Xin-Yu Chen, Yu-Kun Xia, Xiu-Fei Chen, Ren-Qiang Sun, Jing-Ye Zhang, Yi-Ping Sun, Lei Song, Bing-Jie Liu, Rui-Kai Du, Chen Ding, Fei Lan, Sheng-Lin Huang, Feng Zhou, Suling Liu, Yue Xiong, Dan Ye, Kun-Liang Guan
Published 2018-11-01