The Importance of First Impressions: Early Events in Mycobacterium tuberculosis Infection Influence Outcome

by Anthony M. Cadena, JoAnne L. Flynn, Sarah M. Fortune
Published 2016-05-01

Lymph nodes-The neglected battlefield in tuberculosis.

by Sharie Keanne C Ganchua, Alexander G White, Edwin C Klein, JoAnne L Flynn
Published 2020-08-01

Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue.

by Simeone Marino, Dhruv Sud, Hillarie Plessner, Philana Ling Lin, John Chan, JoAnne L Flynn, Denise E Kirschner
Published 2007-10-01

A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination.

by Timothy Wessler, Louis R Joslyn, H Jacob Borish, Hannah P Gideon, JoAnne L Flynn, Denise E Kirschner, Jennifer J Linderman
Published 2020-05-01

Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Mycobacterium tuberculosis Granulomas

by Jess A. Millar, Jess A. Millar, J. Russell Butler, Stephanie Evans, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Published 2021-01-01

Profiling the airway in the macaque model of tuberculosis reveals variable microbial dysbiosis and alteration of community structure

by Anthony M Cadena, Yixuan Ma, Tao Ding, MacKenzie Bryant, Pauline Maiello, Adam Geber, Philana Ling Lin, JoAnne L Flynn, Elodie Ghedin
Published 2018-10-01

A Novel Sample Processing Method for Rapid Detection of Tuberculosis in the Stool of Pediatric Patients Using the Xpert MTB/RIF Assay.

by Padmapriya P Banada, Uvistra Naidoo, Srinidhi Deshpande, Farina Karim, JoAnne L Flynn, Melanie O'Malley, Martin Jones, Oliver Nanassy, Prakash Jeena, David Alland
Published 2016-01-01

Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome.

by Simeone Marino, Hannah P Gideon, Chang Gong, Shawn Mankad, John T McCrone, Philana Ling Lin, Jennifer J Linderman, JoAnne L Flynn, Denise E Kirschner
Published 2016-04-01

Noninvasive Test for Tuberculosis Detection among Primates

by Tiffany M. Wolf, Lawrence Mugisha, Fernanda Miyagaki Shoyama, Melanie J. O’Malley, JoAnne L. Flynn, Benon Asiimwe, Dominic A. Travis, Randall S. Singer, Srinand Sreevatsan
Published 2015-03-01

Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis

by Constance J. Martin, Anthony M. Cadena, Vivian W. Leung, Philana Ling Lin, Pauline Maiello, Nathan Hicks, Michael R. Chase, JoAnne L. Flynn, Sarah M. Fortune, Christina L. Stallings
Published 2017-05-01

Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques.

by Sharie Keanne C Ganchua, Anthony M Cadena, Pauline Maiello, Hannah P Gideon, Amy J Myers, Beth F Junecko, Edwin C Klein, Philana Ling Lin, Joshua T Mattila, JoAnne L Flynn
Published 2018-11-01

Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes

by Louis R. Joslyn, Louis R. Joslyn, Elsje Pienaar, Elsje Pienaar, Robert M. DiFazio, Sara Suliman, Benjamin M. Kagina, JoAnne L. Flynn, Thomas J. Scriba, Jennifer J. Linderman, Denise E. Kirschner
Published 2018-08-01

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis.

by Collin R Diedrich, Tara Rutledge, Pauline Maiello, Tonilynn M Baranowski, Alexander G White, H Jacob Borish, Paul Karell, Forrest Hopkins, Jessica Brown, Sarah M Fortune, JoAnne L Flynn, Zandrea Ambrose, Philana Ling Lin
Published 2020-07-01

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques.

by Anthony M Cadena, Forrest F Hopkins, Pauline Maiello, Allison F Carey, Eileen A Wong, Constance J Martin, Hannah P Gideon, Robert M DiFazio, Peter Andersen, Philana Ling Lin, Sarah M Fortune, JoAnne L Flynn
Published 2018-10-01

Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.

by Hannah Priyadarshini Gideon, JiaYao Phuah, Amy J Myers, Bryan D Bryson, Mark A Rodgers, M Teresa Coleman, Pauline Maiello, Tara Rutledge, Simeone Marino, Sarah M Fortune, Denise E Kirschner, Philana Ling Lin, JoAnne L Flynn
Published 2015-01-01

Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque.

by Guy Zinman, Rachel Brower-Sinning, Chineye H Emeche, Jason Ernst, Grace Tzu-Wei Huang, Shaun Mahony, Amy J Myers, Dawn M O'Dee, JoAnne L Flynn, Gerard J Nau, Ted M Ross, Russell D Salter, Panayiotis V Benos, Ziv Bar Joseph, Penelope A Morel
Published 2011-01-01

PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis.

by Philana Ling Lin, Pauline Maiello, Hannah P Gideon, M Teresa Coleman, Anthony M Cadena, Mark A Rodgers, Robert Gregg, Melanie O'Malley, Jaime Tomko, Daniel Fillmore, L James Frye, Tara Rutledge, Robert M DiFazio, Christopher Janssen, Edwin Klein, Peter L Andersen, Sarah M Fortune, JoAnne L Flynn
Published 2016-07-01

Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques

by Caylin G. Winchell, Bibhuti B. Mishra, Bibhuti B. Mishra, Jia Yao Phuah, Mohd Saqib, Samantha J. Nelson, Pauline Maiello, Chelsea M. Causgrove, Cassaundra L. Ameel, Brianne Stein, H. Jacob Borish, Alexander G. White, Edwin C. Klein, Matthew D. Zimmerman, Véronique Dartois, Philana Ling Lin, Christopher M. Sassetti, JoAnne L. Flynn
Published 2020-05-01

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastroint...

by Amy L Hartman, Sham Nambulli, Cynthia M McMillen, Alexander G White, Natasha Louise Tilston-Lunel, Joseph R Albe, Emily Cottle, Matthew D Dunn, L James Frye, Theron H Gilliland, Emily L Olsen, Katherine J O'Malley, Madeline M Schwarz, Jaime A Tomko, Reagan C Walker, Mengying Xia, Matthew S Hartman, Edwin Klein, Charles A Scanga, JoAnne L Flynn, William B Klimstra, Anita K McElroy, Douglas S Reed, W Paul Duprex
Published 2020-09-01

Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes

by Neesha Rockwood, Neesha Rockwood, Diego L. Costa, Eduardo P. Amaral, Elsa Du Bruyn, Andre Kubler, Andre Kubler, Leonardo Gil-Santana, Leonardo Gil-Santana, Leonardo Gil-Santana, Kiyoshi F. Fukutani, Charles A. Scanga, JoAnne L. Flynn, Sharon H. Jackson, Katalin A. Wilkinson, Katalin A. Wilkinson, William R. Bishai, Alan Sher, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade
Published 2017-05-01