Profiling the airway in the macaque model of tuberculosis reveals variable microbial dysbiosis and alteration of community structure

by Anthony M Cadena, Yixuan Ma, Tao Ding, MacKenzie Bryant, Pauline Maiello, Adam Geber, Philana Ling Lin, JoAnne L Flynn, Elodie Ghedin
Published 2018-10-01

Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis

by Constance J. Martin, Anthony M. Cadena, Vivian W. Leung, Philana Ling Lin, Pauline Maiello, Nathan Hicks, Michael R. Chase, JoAnne L. Flynn, Sarah M. Fortune, Christina L. Stallings
Published 2017-05-01

Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques.

by Sharie Keanne C Ganchua, Anthony M Cadena, Pauline Maiello, Hannah P Gideon, Amy J Myers, Beth F Junecko, Edwin C Klein, Philana Ling Lin, Joshua T Mattila, JoAnne L Flynn
Published 2018-11-01

MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection.

by Amy L Ellis, Alexis J Balgeman, Erica C Larson, Mark A Rodgers, Cassaundra Ameel, Tonilynn Baranowski, Nadean Kannal, Pauline Maiello, Jennifer A Juno, Charles A Scanga, Shelby L O'Connor
Published 2020-05-01

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis.

by Collin R Diedrich, Tara Rutledge, Pauline Maiello, Tonilynn M Baranowski, Alexander G White, H Jacob Borish, Paul Karell, Forrest Hopkins, Jessica Brown, Sarah M Fortune, JoAnne L Flynn, Zandrea Ambrose, Philana Ling Lin
Published 2020-07-01

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques.

by Anthony M Cadena, Forrest F Hopkins, Pauline Maiello, Allison F Carey, Eileen A Wong, Constance J Martin, Hannah P Gideon, Robert M DiFazio, Peter Andersen, Philana Ling Lin, Sarah M Fortune, JoAnne L Flynn
Published 2018-10-01

Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.

by Hannah Priyadarshini Gideon, JiaYao Phuah, Amy J Myers, Bryan D Bryson, Mark A Rodgers, M Teresa Coleman, Pauline Maiello, Tara Rutledge, Simeone Marino, Sarah M Fortune, Denise E Kirschner, Philana Ling Lin, JoAnne L Flynn
Published 2015-01-01

PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis.

by Philana Ling Lin, Pauline Maiello, Hannah P Gideon, M Teresa Coleman, Anthony M Cadena, Mark A Rodgers, Robert Gregg, Melanie O'Malley, Jaime Tomko, Daniel Fillmore, L James Frye, Tara Rutledge, Robert M DiFazio, Christopher Janssen, Edwin Klein, Peter L Andersen, Sarah M Fortune, JoAnne L Flynn
Published 2016-07-01

Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques

by Caylin G. Winchell, Bibhuti B. Mishra, Bibhuti B. Mishra, Jia Yao Phuah, Mohd Saqib, Samantha J. Nelson, Pauline Maiello, Chelsea M. Causgrove, Cassaundra L. Ameel, Brianne Stein, H. Jacob Borish, Alexander G. White, Edwin C. Klein, Matthew D. Zimmerman, Véronique Dartois, Philana Ling Lin, Christopher M. Sassetti, JoAnne L. Flynn
Published 2020-05-01