A Multi-Compartment Hybrid Computational Model Predicts Key Roles for Dendritic Cells in Tuberculosis Infection

by Simeone Marino, Denise E. Kirschner
Published 2016-10-01

Resistance, Remission, and Qualitative Differences in HIV Chemotherapy

by Denise E. Kirschner, G.F. Webb
Published 1997-09-01

Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas.

by Elsje Pienaar, Jennifer J Linderman, Denise E Kirschner
Published 2018-01-01

Harnessing the heterogeneity of T cell differentiation fate to fine-tune generation of effector and memory T cells

by Chang eGong, Jennifer J Linderman, Denise eKirschner
Published 2014-02-01

Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation.

by Stephanie Evans, J Russell Butler, Joshua T Mattila, Denise E Kirschner
Published 2020-12-01

NF-κB signaling dynamics play a key role in infection control in tuberculosis

by Mohammad eFallahi-Sichani, Denise E. Kirschner, Jennifer J. Linderman
Published 2012-06-01

Multi-scale modeling predicts a balance of tumor necrosis factor-α and interleukin-10 controls the granuloma environment during Mycobacterium tuberculosis infection.

by Nicholas A Cilfone, Cory R Perry, Denise E Kirschner, Jennifer J Linderman
Published 2013-01-01

The Role of Dimensionality in Understanding Granuloma Formation

by Simeone Marino, Caitlin Hult, Paul Wolberg, Jennifer J. Linderman, Denise E. Kirschner
Published 2018-11-01

Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas

by Joseph M. Cicchese, Véronique Dartois, Véronique Dartois, Denise E. Kirschner, Jennifer J. Linderman
Published 2020-03-01

Identification of key processes that control tumor necrosis factor availability in a tuberculosis granuloma.

by Mohammad Fallahi-Sichani, Matthew A Schaller, Denise E Kirschner, Steven L Kunkel, Jennifer J Linderman
Published 2010-05-01

Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model

by Hayley C. Warsinske, Elsje Pienaar, Elsje Pienaar, Jennifer J. Linderman, Joshua T. Mattila, Denise E. Kirschner
Published 2017-12-01

Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach.

by Elsje Pienaar, Jansy Sarathy, Brendan Prideaux, Jillian Dietzold, Véronique Dartois, Denise E Kirschner, Jennifer J Linderman
Published 2017-08-01

Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue.

by Simeone Marino, Dhruv Sud, Hillarie Plessner, Philana Ling Lin, John Chan, JoAnne L Flynn, Denise E Kirschner
Published 2007-10-01

Strategic Priming with Multiple Antigens Can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: a Computational Study

by Cordelia eZiraldo, Cordelia eZiraldo, Chang eGong, Chang eGong, Denise eKirschner, Jennifer J Linderman
Published 2016-01-01

Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination

by Caitlin Hult, Joshua T. Mattila, Joshua T. Mattila, Hannah P. Gideon, Hannah P. Gideon, Jennifer J. Linderman, Denise E. Kirschner
Published 2021-10-01

A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination.

by Timothy Wessler, Louis R Joslyn, H Jacob Borish, Hannah P Gideon, JoAnne L Flynn, Denise E Kirschner, Jennifer J Linderman
Published 2020-05-01

Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Mycobacterium tuberculosis Granulomas

by Jess A. Millar, Jess A. Millar, J. Russell Butler, Stephanie Evans, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Published 2021-01-01

Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo.

by Teresa Repasy, Jinhee Lee, Simeone Marino, Nuria Martinez, Denise E Kirschner, Gregory Hendricks, Stephen Baker, Andrew A Wilson, Darrell N Kotton, Hardy Kornfeld
Published 2013-02-01

Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome.

by Simeone Marino, Hannah P Gideon, Chang Gong, Shawn Mankad, John T McCrone, Philana Ling Lin, Jennifer J Linderman, JoAnne L Flynn, Denise E Kirschner
Published 2016-04-01

Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes

by Louis R. Joslyn, Louis R. Joslyn, Elsje Pienaar, Elsje Pienaar, Robert M. DiFazio, Sara Suliman, Benjamin M. Kagina, JoAnne L. Flynn, Thomas J. Scriba, Jennifer J. Linderman, Denise E. Kirschner
Published 2018-08-01