Lipid raft-mediated regulation of G-protein coupled receptor signaling by ligands which influence receptor dimerization: a computational study.

by Mohammad Fallahi-Sichani, Jennifer J Linderman
Published 2009-08-01

Both ligand- and cell-specific parameters control ligand agonism in a kinetic model of g protein-coupled receptor signaling.

by Tamara L Kinzer-Ursem, Jennifer J Linderman
Published 2007-01-01

Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas.

by Elsje Pienaar, Jennifer J Linderman, Denise E Kirschner
Published 2018-01-01

Harnessing the heterogeneity of T cell differentiation fate to fine-tune generation of effector and memory T cells

by Chang eGong, Jennifer J Linderman, Denise eKirschner
Published 2014-02-01

NF-κB signaling dynamics play a key role in infection control in tuberculosis

by Mohammad eFallahi-Sichani, Denise E. Kirschner, Jennifer J. Linderman
Published 2012-06-01

The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue.

by Phillip C Spinosa, Kathryn E Luker, Gary D Luker, Jennifer J Linderman
Published 2017-01-01

Multi-scale modeling predicts a balance of tumor necrosis factor-α and interleukin-10 controls the granuloma environment during Mycobacterium tuberculosis infection.

by Nicholas A Cilfone, Cory R Perry, Denise E Kirschner, Jennifer J Linderman
Published 2013-01-01

The Role of Dimensionality in Understanding Granuloma Formation

by Simeone Marino, Caitlin Hult, Paul Wolberg, Jennifer J. Linderman, Denise E. Kirschner
Published 2018-11-01

A multi-scale pipeline linking drug transcriptomics with pharmacokinetics predicts in vivo interactions of tuberculosis drugs

by Joseph M. Cicchese, Awanti Sambarey, Denise Kirschner, Jennifer J. Linderman, Sriram Chandrasekaran
Published 2021-03-01

Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas

by Joseph M. Cicchese, Véronique Dartois, Véronique Dartois, Denise E. Kirschner, Jennifer J. Linderman
Published 2020-03-01

Cell, isoform, and environment factors shape gradients and modulate chemotaxis.

by S Laura Chang, Stephen P Cavnar, Shuichi Takayama, Gary D Luker, Jennifer J Linderman
Published 2015-01-01

Identification of key processes that control tumor necrosis factor availability in a tuberculosis granuloma.

by Mohammad Fallahi-Sichani, Matthew A Schaller, Denise E Kirschner, Steven L Kunkel, Jennifer J Linderman
Published 2010-05-01

Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model

by Hayley C. Warsinske, Elsje Pienaar, Elsje Pienaar, Jennifer J. Linderman, Joshua T. Mattila, Denise E. Kirschner
Published 2017-12-01

Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach.

by Elsje Pienaar, Jansy Sarathy, Brendan Prideaux, Jillian Dietzold, Véronique Dartois, Denise E Kirschner, Jennifer J Linderman
Published 2017-08-01

Correction: Cell, Isoform, and Environment Factors Shape Gradients and Modulate Chemotaxis.

by S Laura Chang, Stephen P Cavnar, Kathryn E Luker, Shuichi Takayama, Gary D Luker, Jennifer J Linderman
Published 2017-01-01

Strategic Priming with Multiple Antigens Can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: a Computational Study

by Cordelia eZiraldo, Cordelia eZiraldo, Chang eGong, Chang eGong, Denise eKirschner, Jennifer J Linderman
Published 2016-01-01

Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination

by Caitlin Hult, Joshua T. Mattila, Joshua T. Mattila, Hannah P. Gideon, Hannah P. Gideon, Jennifer J. Linderman, Denise E. Kirschner
Published 2021-10-01

CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7.

by Nathaniel L Coggins, Danielle Trakimas, S Laura Chang, Anna Ehrlich, Paramita Ray, Kathryn E Luker, Jennifer J Linderman, Gary D Luker
Published 2014-01-01

Phase-locked signals elucidate circuit architecture of an oscillatory pathway.

by Andreja Jovic, Bryan Howell, Michelle Cote, Susan M Wade, Khamir Mehta, Atsushi Miyawaki, Richard R Neubig, Jennifer J Linderman, Shuichi Takayama
Published 2010-12-01

A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination.

by Timothy Wessler, Louis R Joslyn, H Jacob Borish, Hannah P Gideon, JoAnne L Flynn, Denise E Kirschner, Jennifer J Linderman
Published 2020-05-01