C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly

by Shen, Kuang, Sabatini, David M.
Published 2020

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

by Shen, Kuang, Choe, Abigail D., Sabatini, David
Published 2018

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

by Grabiner, Brian C., Nardi, Valentina, Birsoy, Kivanc, Possemato, Richard, Shen, Kuang, Sinha, Sumi, Jordan, Alexander, Beck, Andrew H., Sabatini, David
Published 2015

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes

by Shen, Kuang, Bomaliyamu, Aimaiti, Hong, Chuan, Yu, Zhiheng, Huang, Rick, Brignole, Edward J, Condon, Kendall Janine, Valenstein, Max L., Chantranupong, Lynne, Choe, Abigail D., Sabatini, David
Published 2018

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

by Gygi, Melanie P., Shen, Kuang, Harper, J. Wade, Gygi, Steven P., Chantranupong, Lynne, Scaria, Sonia M., Saxton, Robert Andrew, Wyant, Gregory Andrew, Wang, Tim, Sabatini, David
Published 2017

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

by Shen, Kuang, Petri, Sabrina, Abu-Remaileh, Monther, Frankel, Wayne N., Wolfson, Rachel Laura, Chantranupong, Lynne, Wyant, Gregory Andrew, Gu, Xin, Orozco Segrera, Jose, Condon, Kendall Janine, Kedir, Jibril Fetu, Scaria, Sonia M., Sabatini, David
Published 2018

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

by Plovanich, M. E., Straub, C., Sabatini, B. L., Tsun, Zhi-Yang, Wang, Shuyu, Wolfson, Rachel Laura, Shen, Kuang, Wyant, Gregory Andrew, Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William C., Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Kim, Choah, Park, Jiwon, Sabatini, David
Published 2015