The APC Network Regulates the Removal of Mutated Cells from Colonic Crypts

by Je-Hoon Song, David J. Huels, Rachel A. Ridgway, Owen J. Sansom, Boris N. Kholodenko, Walter Kolch, Kwang-Hyun Cho
Published 2014-04-01

Luminal Iron Levels Govern Intestinal Tumorigenesis after Apc Loss In Vivo

by Sorina Radulescu, Matthew J. Brookes, Pedro Salgueiro, Rachel A. Ridgway, Ewan McGhee, Kurt Anderson, Samuel J. Ford, Daniel H. Stones, Tariq H. Iqbal, Chris Tselepis, Owen J. Sansom
Published 2012-08-01

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

by Georgios Kanellos, Jing Zhou, Hitesh Patel, Rachel A. Ridgway, David Huels, Christine B. Gurniak, Emma Sandilands, Neil O. Carragher, Owen J. Sansom, Walter Witke, Valerie G. Brunton, Margaret C. Frame
Published 2015-12-01

Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

by David M. Gay, Rachel A. Ridgway, Miryam Müller, Michael C. Hodder, Ann Hedley, William Clark, Joshua D. Leach, Rene Jackstadt, Colin Nixon, David J. Huels, Andrew D. Campbell, Thomas G. Bird, Owen J. Sansom
Published 2019-03-01

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

by David M. Gay, Rachel A. Ridgway, Miryam Müller, Michael C. Hodder, Ann Hedley, William Clark, Joshua D. Leach, Rene Jackstadt, Colin Nixon, David J. Huels, Andrew D. Campbell, Thomas G. Bird, Owen J. Sansom
Published 2019-02-01

Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron

by Nils O Lindström, Melanie L Lawrence, Sally F Burn, Jeanette A Johansson, Elvira RM Bakker, Rachel A Ridgway, C-Hong Chang, Michele J Karolak, Leif Oxburgh, Denis J Headon, Owen J Sansom, Ron Smits, Jamie A Davies, Peter Hohenstein
Published 2015-02-01

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

by Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas K. Hock, Nathalie Legrave, Oliver D. K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen J. Sansom, Karen H. Vousden
Published 2021-01-01

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

by Patrizia Cammareri, Aidan M. Rose, David F. Vincent, Jun Wang, Ai Nagano, Silvana Libertini, Rachel A. Ridgway, Dimitris Athineos, Philip J. Coates, Angela McHugh, Celine Pourreyron, Jasbani H. S. Dayal, Jonas Larsson, Simone Weidlich, Lindsay C. Spender, Gopal P. Sapkota, Karin J. Purdie, Charlotte M. Proby, Catherine A. Harwood, Irene M. Leigh, Hans Clevers, Nick Barker, Stefan Karlsson, Catrin Pritchard, Richard Marais, Claude Chelala, Andrew P. South, Owen J. Sansom, Gareth J. Inman
Published 2016-08-01

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

by Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom
Published 2021-06-01

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

by Zahra Erami, David Herrmann, Sean C. Warren, Max Nobis, Ewan J. McGhee, Morghan C. Lucas, Wilfred Leung, Nadine Reischmann, Agata Mrowinska, Juliane P. Schwarz, Shereen Kadir, James R.W. Conway, Claire Vennin, Saadia A. Karim, Andrew D. Campbell, David Gallego-Ortega, Astrid Magenau, Kendelle J. Murphy, Rachel A. Ridgway, Andrew M. Law, Stacey N. Walters, Shane T. Grey, David R. Croucher, Lei Zhang, Herbert Herzog, Edna C. Hardeman, Peter W. Gunning, Christopher J. Ormandy, T.R. Jeffry Evans, Douglas Strathdee, Owen J. Sansom, Jennifer P. Morton, Kurt I. Anderson, Paul Timpson
Published 2016-01-01