Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell

by Nathalie Sphyris, Michael C. Hodder, Owen J. Sansom
Published 2021-02-01

Exploring molecular genetics of bladder cancer: lessons learned from mouse models

by Imran Ahmad, Owen J. Sansom, Hing Y. Leung
Published 2012-05-01

GEMMs as preclinical models for testing pancreatic cancer therapies

by Aarthi Gopinathan, Jennifer P. Morton, Duncan I. Jodrell, Owen J. Sansom
Published 2015-10-01

Functional exploration of colorectal cancer genomes using Drosophila

by Erdem Bangi, Claudio Murgia, Alexander G.S. Teague, Owen J. Sansom, Ross L. Cagan
Published 2016-11-01

FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells.

by Kathryn Graham, Kim Moran-Jones, Owen J Sansom, Valerie G Brunton, Margaret C Frame
Published 2011-01-01

Pre-clinical modelling of rectal cancer to develop novel radiotherapy-based treatment strategies

by Michael A. Gillespie, Colin W. Steele, Tamsin R.M. Lannagan, Owen J. Sansom, Campbell S.D. Roxburgh
Published 2021-06-01

Systems level expression correlation of Ras GTPase regulators

by E. Besray Unal, Christina Kiel, Hannah Benisty, Andrew Campbell, Karen Pickering, Nils Blüthgen, Owen J. Sansom, Luis Serrano
Published 2018-08-01

The APC Network Regulates the Removal of Mutated Cells from Colonic Crypts

by Je-Hoon Song, David J. Huels, Rachel A. Ridgway, Owen J. Sansom, Boris N. Kholodenko, Walter Kolch, Kwang-Hyun Cho
Published 2014-04-01

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine.

by Boris Y Shorning, Joanna Zabkiewicz, Afshan McCarthy, Helen B Pearson, Douglas J Winton, Owen J Sansom, Alan Ashworth, Alan R Clarke
Published 2009-01-01

Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine

by Boris Y. Shorning, Joanna Zabkiewicz, Afshan McCarthy, Helen B. Pearson, Douglas J. Winton, Owen J. Sansom, Alan Ashworth, Alan R. Clarke
Published 2009-01-01

Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine.

by Boris Y. Shorning, Joanna Zabkiewicz, Afshan McCarthy, Helen B. Pearson, Douglas J. Winton, Owen J. Sansom, Alan Ashworth, Alan R. Clarke
Published 2009-01-01

Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine.

by Boris Y Shorning, Joanna Zabkiewicz, Afshan McCarthy, Helen B Pearson, Douglas J Winton, Owen J Sansom, Alan Ashworth, Alan R Clarke
Published 2019-01-01

Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments.

by Kirsty J Martin, Ewan J McGhee, Juliana P Schwarz, Martin Drysdale, Saskia M Brachmann, Volker Stucke, Owen J Sansom, Kurt I Anderson
Published 2018-01-01

Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.

by Ai Tian, Hassina Benchabane, Zhenghan Wang, Chloe Zimmerman, Nan Xin, Jessica Perochon, Gabriela Kalna, Owen J Sansom, Chao Cheng, Julia B Cordero, Yashi Ahmed
Published 2017-07-01

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder

by Imran Ahmad, Lukram Babloo Singh, Mona Foth, Carol-Ann Morris, Makoto Mark Taketo, Xue-Ru Wu, Hing Y. Leung, Owen J. Sansom, Tomoko Iwata
Published 2011-07-01

Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

by Evdokia Michalopoulou, Francesca R. Auciello, Vinay Bulusu, David Strachan, Andrew D. Campbell, Jacqueline Tait-Mulder, Saadia A. Karim, Jennifer P. Morton, Owen J. Sansom, Jurre J. Kamphorst
Published 2020-02-01

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

by Christine Gundry, Sergi Marco, Elena Rainero, Bryan Miller, Emmanuel Dornier, Louise Mitchell, Patrick T. Caswell, Andrew D. Campbell, Anna Hogeweg, Owen J. Sansom, Jennifer P. Morton, Jim C. Norman
Published 2017-03-01

The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma

by Joanna Birch, Cassie J. Clarke, Andrew D. Campbell, Kirsteen Campbell, Louise Mitchell, Dritan Liko, Gabriela Kalna, Douglas Strathdee, Owen J. Sansom, Matthew Neilson, Karen Blyth, Jim C. Norman
Published 2016-10-01

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

by Máté Nászai, Karen Bellec, Yachuan Yu, Alvaro Román-Fernández, Emma Sandilands, Joel Johansson, Andrew D Campbell, Jim C Norman, Owen J Sansom, David M Bryant, Julia B Cordero
Published 2021-06-01

Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis

by Alexander Greenhough, Clare Bagley, Kate J Heesom, David B Gurevich, David Gay, Mark Bond, Tracey J Collard, Chris Paraskeva, Paul Martin, Owen J Sansom, Karim Malik, Ann C Williams
Published 2018-11-01