Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease

by Dag Sehlin, Xiaotian T. Fang, Linda Cato, Gunnar Antoni, Lars Lannfelt, Stina Syvänen
Published 2016-02-01

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

by Gabriel Gustafsson, Veronica Lindström, Jinar Rostami, Eva Nordström, Lars Lannfelt, Joakim Bergström, Martin Ingelsson, Anna Erlandsson
Published 2017-12-01

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

by Sofia Söllvander, Elisabeth Nikitidou, Linn Gallasch, Marlena Zyśk, Linda Söderberg, Dag Sehlin, Lars Lannfelt, Anna Erlandsson
Published 2018-03-01

Large aggregates are the major soluble Aβ species in AD brain fractionated with density gradient ultracentrifugation.

by Dag Sehlin, Hillevi Englund, Barbro Simu, Mikael Karlsson, Martin Ingelsson, Fredrik Nikolajeff, Lars Lannfelt, Frida Ekholm Pettersson
Published 2012-01-01

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody

by Stina Syvänen, Greta Hultqvist, Tobias Gustavsson, Astrid Gumucio, Hanna Laudon, Linda Söderberg, Martin Ingelsson, Lars Lannfelt, Dag Sehlin
Published 2018-05-01

Decreased proportion of cytomegalovirus specific CD8 T-cells but no signs of general immunosenescence in Alzheimer's disease.

by Gabriel Westman, Anna-Karin Lidehall, Peetra Magnusson, Martin Ingelsson, Lena Kilander, Lars Lannfelt, Olle Korsgren, Britt-Marie Eriksson
Published 2013-01-01

Reduced plasma desmosterol‐to‐cholesterol ratio and longitudinal cognitive decline in Alzheimer's disease

by Yoshiaki Sato, Francois Bernier, Yasukazu Yamanaka, Ken Aoshima, Yoshiya Oda, Martin Ingelsson, Lars Lannfelt, Akinori Miyashita, Ryozo Kuwano, Takeshi Ikeuchi
Published 2015-03-01

Antibodies against alpha-synuclein reduce oligomerization in living cells.

by Thomas Näsström, Susana Gonçalves, Charlotte Sahlin, Eva Nordström, Valentina Screpanti Sundquist, Lars Lannfelt, Joakim Bergström, Tiago F Outeiro, Martin Ingelsson
Published 2011-01-01

Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer's disease.

by Gabriel Westman, David Berglund, Johan Widén, Martin Ingelsson, Olle Korsgren, Lars Lannfelt, Dag Sehlin, Anna-Karin Lidehall, Britt-Marie Eriksson
Published 2014-01-01

Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease.

by Payam Emami Khoonsari, Anna Häggmark, Maria Lönnberg, Maria Mikus, Lena Kilander, Lars Lannfelt, Jonas Bergquist, Martin Ingelsson, Peter Nilsson, Kim Kultima, Ganna Shevchenko
Published 2016-01-01

Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease

by Xiao Zhang, Paul O’Callaghan, Honglian Li, Yingxia Tan, Ganlin Zhang, Uri Barash, Xiaomin Wang, Lars Lannfelt, Israel Vlodavsky, Ulf Lindahl, Jin-Ping Li
Published 2021-05-01

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

by Fadi Rofo, Jos Buijs, Ronny Falk, Ken Honek, Lars Lannfelt, Anna M. Lilja, Nicole G. Metzendorf, Tobias Gustavsson, Dag Sehlin, Linda Söderberg, Greta Hultqvist
Published 2021-09-01

An amyloid-β protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

by Anna Lord, Astrid Gumucio, Hillevi Englund, Dag Sehlin, Valentina Screpanti Sundquist, Linda Söderberg, Christer Möller, Pär Gellerfors, Lars Lannfelt, Frida Ekholm Pettersson, Lars N.G. Nilsson
Published 2009-12-01

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

by Fabian Hosp, Hannes Vossfeldt, Matthias Heinig, Djordje Vasiljevic, Anup Arumughan, Emanuel Wyler, Markus Landthaler, Norbert Hubner, Erich E. Wanker, Lars Lannfelt, Martin Ingelsson, Maciej Lalowski, Aaron Voigt, Matthias Selbach
Published 2015-05-01

Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

by Elin S. Blom, Yijing Wang, Lena Skoglund, Anita C. Hansson, Massimo Ubaldi, Anbarasu Lourdusamy, Wolfgang H. Sommer, Matthew Mielke, Bradley T. Hyman, Markus Heilig, Lars Lannfelt, Lars N. G. Nilsson, Martin Ingelsson
Published 2011-01-01

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

by Veronica Lindström, Therese Fagerqvist, Eva Nordström, Fredrik Eriksson, Anna Lord, Stina Tucker, Jessica Andersson, Malin Johannesson, Heinrich Schell, Philipp J. Kahle, Christer Möller, Pär Gellerfors, Joakim Bergström, Lars Lannfelt, Martin Ingelsson
Published 2014-09-01

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease

by Bence György, Camilla Lööv, Mikołaj P. Zaborowski, Shuko Takeda, Benjamin P. Kleinstiver, Caitlin Commins, Ksenia Kastanenka, Dakai Mu, Adrienn Volak, Vilmantas Giedraitis, Lars Lannfelt, Casey A. Maguire, J. Keith Joung, Bradley T. Hyman, Xandra O. Breakefield, Martin Ingelsson
Published 2018-06-01

A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody

by Chad J. Swanson, Yong Zhang, Shobha Dhadda, Jinping Wang, June Kaplow, Robert Y. K. Lai, Lars Lannfelt, Heather Bradley, Martin Rabe, Akihiko Koyama, Larisa Reyderman, Donald A. Berry, Scott Berry, Robert Gordon, Lynn D. Kramer, Jeffrey L. Cummings
Published 2021-04-01

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis.

by Fanny Rubio-Moscardo, Núria Setó-Salvia, Marta Pera, Mònica Bosch-Morató, Cristina Plata, Olivia Belbin, Olivia Belbin, Gemma Gené, Oriol Dols-Icardo, Martin Ingelsson, Seppo Helisalmi, Hilkka Soininen, Mikko Hiltunen, Vilmantas Giedraitis, Lars Lannfelt, Ana Frank, Ma Jesús Bullido, Onofre Combarros, Pascual Sánchez-Juan, Mercè Boada, Lluís Tárraga, Pau Pastor, Jordi Pérez-Tur, Miquel Baquero, José L Molinuevo, Raquel Sánchez-Valle, Pablo Fuentes-Prior, Juan Fortea, Rafael Blesa, Francisco J Muñoz, Alberto Lleó, Miguel A Valverde, Jordi Clarimón
Published 2013-01-01

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.

by Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A Rivas, Heather M Highland, Adam E Locke, Niels Grarup, Hae Kyung Im, Pablo Cingolani, Jason Flannick, Pierre Fontanillas, Christian Fuchsberger, Kyle J Gaulton, Tanya M Teslovich, N William Rayner, Neil R Robertson, Nicola L Beer, Jana K Rundle, Jette Bork-Jensen, Claes Ladenvall, Christine Blancher, David Buck, Gemma Buck, Noël P Burtt, Stacey Gabriel, Anette P Gjesing, Christopher J Groves, Mette Hollensted, Jeroen R Huyghe, Anne U Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S Small, Heather M Stringham, Ann-Christine Syvänen, Joseph Trakalo, Goncalo Abecasis, Graeme I Bell, John Blangero, Nancy J Cox, Ravindranath Duggirala, Craig L Hanis, Mark Seielstad, James G Wilson, Cramer Christensen, Ivan Brandslund, Rainer Rauramaa, Gabriela L Surdulescu, Alex S F Doney, Lars Lannfelt, Allan Linneberg, Bo Isomaa, Tiinamaija Tuomi, Marit E Jørgensen, Torben Jørgensen, Johanna Kuusisto, Matti Uusitupa, Veikko Salomaa, Timothy D Spector, Andrew D Morris, Colin N A Palmer, Francis S Collins, Karen L Mohlke, Richard N Bergman, Erik Ingelsson, Lars Lind, Jaakko Tuomilehto, Torben Hansen, Richard M Watanabe, Inga Prokopenko, Josee Dupuis, Fredrik Karpe, Leif Groop, Markku Laakso, Oluf Pedersen, Jose C Florez, Andrew P Morris, David Altshuler, James B Meigs, Michael Boehnke, Mark I McCarthy, Cecilia M Lindgren, Anna L Gloyn, T2D-GENES consortium and GoT2D consortium
Published 2015-01-01