Innate and adaptive immune traits are differentially affected by genetic and environmental factors

by Massimo Mangino, Mario Roederer, Margaret H. Beddall, Frank O. Nestle, Tim D. Spector
Published 2017-01-01

Immune Trait Shifts in Association With Tobacco Smoking: A Study in Healthy Women

by Giulia Piaggeschi, Giulia Piaggeschi, Simona Rolla, Niccolò Rossi, Davide Brusa, Alessio Naccarati, Alessio Naccarati, Simon Couvreur, Tim D. Spector, Mario Roederer, Massimo Mangino, Massimo Mangino, Francesca Cordero, Mario Falchi, Alessia Visconti
Published 2021-03-01

Dietary Influence on Systolic and Diastolic Blood Pressure in the TwinsUK Cohort

by Panayiotis Louca, Olatz Mompeo, Emily R. Leeming, Sarah E. Berry, Massimo Mangino, Tim D. Spector, Sandosh Padmanabhan, Cristina Menni
Published 2020-07-01

The rate of nonallelic homologous recombination in males is highly variable, correlated between monozygotic twins and independent of age.

by Jacqueline A L MacArthur, Timothy D Spector, Sarah J Lindsay, Massimo Mangino, Raj Gill, Kerrin S Small, Matthew E Hurles
Published 2014-03-01

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis

by Ana M. Valdes, Srinivasarao Ravipati, Petros Pousinis, Cristina Menni, Massimo Mangino, Abhishek Abhishek, Victoria Chapman, David A. Barrett, Michael Doherty
Published 2018-09-01

Characterizing Blood Metabolomics Profiles Associated with Self-Reported Food Intakes in Female Twins.

by Tess Pallister, Amy Jennings, Robert P Mohney, Darioush Yarand, Massimo Mangino, Aedin Cassidy, Alexander MacGregor, Tim D Spector, Cristina Menni
Published 2016-01-01

Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms.

by Idil Yet, Cristina Menni, So-Youn Shin, Massimo Mangino, Nicole Soranzo, Jerzy Adamski, Karsten Suhre, Tim D Spector, Gabi Kastenmüller, Jordana T Bell
Published 2016-01-01

Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis.

by Nicholas S Kalson, Tim M Brock, Massimo Mangino, Stella M Fabiane, Derek A Mann, Lee A Borthwick, David J Deehan, Frances M K Williams
Published 2018-01-01

Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

by Christopher G. Bell, Fei Gao, Wei Yuan, Leonie Roos, Richard J. Acton, Yudong Xia, Jordana Bell, Kirsten Ward, Massimo Mangino, Pirro G. Hysi, Jun Wang, Timothy D. Spector
Published 2018-01-01

Consumption of Stilbenes and Flavonoids is Linked to Reduced Risk of Obesity Independently of Fiber Intake

by Olatz Mompeo, Tim D. Spector, Marisa Matey Hernandez, Caroline Le Roy, Geoffrey Istas, Melanie Le Sayec, Massimo Mangino, Amy Jennings, Ana Rodriguez-Mateos, Ana M. Valdes, Cristina Menni
Published 2020-06-01

A genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients

by Ricardo Khouri, Gilvanéia Silva-Santos, Tim Dierckx, Soraya Maria Menezes, Daniele Decanine, Kristof Theys, Aline Clara Silva, Lourdes Farré, Achiléa Bittencourt, Massimo Mangino, Mario Roederer, Anne-Mieke Vandamme, Johan Van Weyenbergh
Published 2018-05-01

Glycosylation of immunoglobulin g: role of genetic and epigenetic influences.

by Cristina Menni, Toma Keser, Massimo Mangino, Jordana T Bell, Idil Erte, Irena Akmačić, Frano Vučković, Maja Pučić Baković, Olga Gornik, Mark I McCarthy, Vlatka Zoldoš, Tim D Spector, Gordan Lauc, Ana M Valdes
Published 2013-01-01

Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

by Xia Shen, Lucija Klarić, Sodbo Sharapov, Massimo Mangino, Zheng Ning, Di Wu, Irena Trbojević-Akmačić, Maja Pučić-Baković, Igor Rudan, Ozren Polašek, Caroline Hayward, Timothy D. Spector, James F. Wilson, Gordan Lauc, Yurii S. Aulchenko
Published 2017-09-01

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

by Cristina Menni, Panayiotis Louca, Sarah E. Berry, Amrita Vijay, Stuart Astbury, Emily R. Leeming, Rachel Gibson, Francesco Asnicar, Gianmarco Piccinno, Jonathan Wolf, Richard Davies, Massimo Mangino, Nicola Segata, Tim D. Spector, Ana M. Valdes
Published 2021-02-01

Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes

by Cristina Menni, Jialing Zhu, Caroline I Le Roy, Olatz Mompeo, Kristin Young, Casey M. Rebholz, Elizabeth Selvin, Kari E. North, Robert P Mohney, Jordana T Bell, Eric Boerwinkle, Tim D Spector, Massimo Mangino, Bing Yu, Ana M Valdes
Published 2020-11-01

The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study.

by Elisabeth Altmaier, Cristina Menni, Margit Heier, Christa Meisinger, Barbara Thorand, Jan Quell, Michael Kobl, Werner Römisch-Margl, Ana M Valdes, Massimo Mangino, Melanie Waldenberger, Konstantin Strauch, Thomas Illig, Jerzy Adamski, Tim Spector, Christian Gieger, Karsten Suhre, Gabi Kastenmüller
Published 2016-01-01

A common variant in the telomerase RNA component is associated with short telomere length.

by Omer T Njajou, Elizabeth H Blackburn, Ludmila Pawlikowska, Massimo Mangino, Coleen M Damcott, Pui-Yan Kwok, Timothy D Spector, Anne B Newman, Tamara B Harris, Steven R Cummings, Richard M Cawthon, Alan R Shuldiner, Ana M Valdes, Wen-Chi Hsueh
Published 2010-09-01

Dysregulated Antibody, Natural Killer Cell and Immune Mediator Profiles in Autoimmune Thyroid Diseases

by Tiphaine C. Martin, Kristina M. Illieva, Alessia Visconti, Michelle Beaumont, Steven J. Kiddle, Richard J. B. Dobson, Massimo Mangino, Ee Mun Lim, Marija Pezer, Claire J. Steves, Jordana T. Bell, Scott G. Wilson, Gordan Lauc, Mario Roederer, John P. Walsh, Tim D. Spector, Sophia N. Karagiannis
Published 2020-03-01

Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans.

by Giorgio Pistis, Shawntel U Okonkwo, Michela Traglia, Cinzia Sala, So-Youn Shin, Corrado Masciullo, Iwan Buetti, Roberto Massacane, Massimo Mangino, Swee-Lay Thein, Timothy D Spector, Santhi Ganesh, CHARGE Consortium Hematology Working, Nicola Pirastu, Paolo Gasparini, Nicole Soranzo, Clara Camaschella, Daniel Hart, Michael R Green, Daniela Toniolo
Published 2013-01-01

Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

by Pei-Chien Tsai, Craig A. Glastonbury, Melissa N. Eliot, Sailalitha Bollepalli, Idil Yet, Juan E. Castillo-Fernandez, Elena Carnero-Montoro, Thomas Hardiman, Tiphaine C. Martin, Alice Vickers, Massimo Mangino, Kirsten Ward, Kirsi H. Pietiläinen, Panos Deloukas, Tim D. Spector, Ana Viñuela, Eric B. Loucks, Miina Ollikainen, Karl T. Kelsey, Kerrin S. Small, Jordana T. Bell
Published 2018-10-01