The Importance of Global Studies of the Genetics of Type 2 Diabetes

by Mark I. McCarthy
Published 2011-04-01

The Importance of Context: Uncovering Species- and Tissue-Specific Effects of Genetic Risk Variants for Type 2 Diabetes

by Soren Krogsgaard Thomsen, Mark I McCarthy, Mark I McCarthy, Mark I McCarthy, Anna L Gloyn, Anna L Gloyn, Anna L Gloyn
Published 2016-08-01

Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study.

by Michael Wainberg, Anubha Mahajan, Anshul Kundaje, Mark I McCarthy, Erik Ingelsson, Nasa Sinnott-Armstrong, Manuel A Rivas
Published 2019-12-01

Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci.

by Martijn van de Bunt, Adrian Cortes, IGAS Consortium, Matthew A Brown, Andrew P Morris, Mark I McCarthy
Published 2015-01-01

PLOS Genetics Data Sharing Policy: In Pursuit of Functional Utility.

by Gregory S Barsh, Gregory M Cooper, Gregory P Copenhaver, Greg Gibson, Mark I McCarthy, Hua Tang, Scott M Williams
Published 2015-12-01

A Protein Domain and Family Based Approach to Rare Variant Association Analysis.

by Tom G Richardson, Hashem A Shihab, Manuel A Rivas, Mark I McCarthy, Colin Campbell, Nicholas J Timpson, Tom R Gaunt
Published 2016-01-01

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.

by Bahram Jafar-Mohammadi, Christopher J Groves, Katharine R Owen, Timothy M Frayling, Andrew T Hattersley, Mark I McCarthy, Anna L Gloyn
Published 2009-08-01

Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes.

by Delphine Fradin, Sophie Le Fur, Clémence Mille, Nadia Naoui, Chris Groves, Diana Zelenika, Mark I McCarthy, Mark Lathrop, Pierre Bougnères
Published 2012-01-01

Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

by Agata Wesolowska-Andersen, Grace Zhuo Yu, Vibe Nylander, Fernando Abaitua, Matthias Thurner, Jason M Torres, Anubha Mahajan, Anna L Gloyn, Mark I McCarthy
Published 2020-01-01

Burden of Diabetes and First Evidence for the Utility of HbA1c for Diagnosis and Detection of Diabetes in Urban Black South Africans: The Durban Diabetes Study.

by Thomas R Hird, Fraser J Pirie, Tonya M Esterhuizen, Brian O'Leary, Mark I McCarthy, Elizabeth H Young, Manjinder S Sandhu, Ayesha A Motala
Published 2016-01-01

Genes Associated with Pancreas Development and Function Maintain Open Chromatin in iPSCs Generated from Human Pancreatic Beta Cells

by Matthias Thurner, Liraz Shenhav, Agata Wesolowska-Andersen, Amanda J. Bennett, Amy Barrett, Anna L. Gloyn, Mark I. McCarthy, Nicola L. Beer, Shimon Efrat
Published 2017-11-01

Metabolic profiling in Maturity-onset diabetes of the young (MODY) and young onset type 2 diabetes fails to detect robust urinary biomarkers.

by Anna L Gloyn, Johan H Faber, Daniel Malmodin, Gaya Thanabalasingham, Francis Lam, Per Magne Ueland, Mark I McCarthy, Katharine R Owen, Dorrit Baunsgaard
Published 2012-01-01

Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable.

by Debbie A Lawlor, Nicholas J Timpson, Roger M Harbord, Sam Leary, Andy Ness, Mark I McCarthy, Timothy M Frayling, Andrew T Hattersley, George Davey Smith
Published 2008-03-01

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

by Juan Fernández-Tajes, Kyle J. Gaulton, Martijn van de Bunt, Jason Torres, Matthias Thurner, Anubha Mahajan, Anna L. Gloyn, Kasper Lage, Mark I. McCarthy
Published 2019-03-01

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis.

by Martijn van de Bunt, Kyle J Gaulton, Leopold Parts, Ignasi Moran, Paul R Johnson, Cecilia M Lindgren, Jorge Ferrer, Anna L Gloyn, Mark I McCarthy
Published 2013-01-01

Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery.

by Reedik Mägi, Sean Manning, Ahmed Yousseif, Andrea Pucci, Ferruccio Santini, Efthimia Karra, Giorgia Querci, Caterina Pelosini, Mark I McCarthy, Cecilia M Lindgren, Rachel L Batterham
Published 2013-01-01

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.

by Michael N Weedon, Mark I McCarthy, Graham Hitman, Mark Walker, Christopher J Groves, Eleftheria Zeggini, N William Rayner, Beverley Shields, Katharine R Owen, Andrew T Hattersley, Timothy M Frayling
Published 2006-10-01

BMI-associated alleles do not constitute risk alleles for polycystic ovary syndrome independently of BMI: a case-control study.

by Yvonne V Louwers, Nigel W Rayner, Blanca M Herrera, Lisette Stolk, Christopher J Groves, Thomas M Barber, Andre G Uitterlinden, Stephen Franks, Joop S E Laven, Mark I McCarthy
Published 2014-01-01

Bone mineral density and risk of type 2 diabetes and coronary heart disease: A Mendelian randomization study [version 1; referees: 2 approved, 1 approved with reservations]

by Wei Gan, Robert J. Clarke, Anubha Mahajan, Benard Kulohoma, Hidetoshi Kitajima, Neil R. Robertson, N. William Rayner, Robin G. Walters, Michael V. Holmes, Zhengming Chen, Mark I. McCarthy
Published 2017-08-01

Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade

by Zia Khan, Christian Hammer, Jonathan Carroll, Flavia Di Nucci, Sergio Ley Acosta, Vidya Maiya, Tushar Bhangale, Julie Hunkapiller, Ira Mellman, Matthew L. Albert, Mark I. McCarthy, G. Scott Chandler
Published 2021-06-01