Deep ocean metagenomes provide insight into the metabolic architecture of bathypelagic microbial communities

by Silvia G. Acinas, Pablo Sánchez, Guillem Salazar, Francisco M. Cornejo-Castillo, Marta Sebastián, Ramiro Logares, Marta Royo-Llonch, Lucas Paoli, Shinichi Sunagawa, Pascal Hingamp, Hiroyuki Ogata, Gipsi Lima-Mendez, Simon Roux, José M. González, Jesús M. Arrieta, Intikhab S. Alam, Allan Kamau, Chris Bowler, Jeroen Raes, Stéphane Pesant, Peer Bork, Susana Agustí, Takashi Gojobori, Dolors Vaqué, Matthew B. Sullivan, Carlos Pedrós-Alió, Ramon Massana, Carlos M. Duarte, Josep M. Gasol
Published 2021-05-01

Temporal evolution of sulfadoxine-pyrimethamine resistance genotypes and genetic diversity in response to a decade of increased interventions against Plasmodium falciparum in north...

by Lucas N. Amenga-Etego, Victor Asoala, Godfred Agongo, Christopher Jacob, Sonia Goncalves, Gordon A. Awandare, Kirk A. Rockett, Dominic Kwiatkowski
Published 2021-03-01

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

by Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P. Khawaja, Sarah Pendergrass, Xikun Han, Jue Sheng Ong, Alex W. Hewitt, Ayellet V. Segrè, John M. Rouhana, Andrew R. Hamel, Robert P. Igo, Helene Choquet, Ayub Qassim, Navya S. Josyula, Jessica N. Cooke Bailey, Pieter W. M. Bonnemaijer, Adriana Iglesias, Owen M. Siggs, Terri L. Young, Veronique Vitart, Alberta A. H. J. Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B. Melles, K. Saidas Nair, Robert Luben, Mark Simcoe, Nishani Amersinghe, Angela J. Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi-Song Rong, Tin Aung, Eranga Nishanthie Vithana, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K. Lupton, Nicholas G. Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E. Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J. Foster, Peng T. Khaw, James E. Morgan, Nicholas G. Strouthidis, Peter Kraft, Jae H. Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J. Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L. Haines, Chris Hammond, Louis R. Pasquale, Caroline C. W. Klaver, Michael Hauser, Chiea Chuen Khor, David A. Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E. Craig, Stuart MacGregor, Janey L. Wiggs
Published 2021-02-01

Machine Learning Prediction of Resistance to Subinhibitory Antimicrobial Concentrations from <named-content content-type="genus-species">Escherichia coli</named-content> Genomes

by Sam Benkwitz-Bedford, Martin Palm, Talip Yasir Demirtas, Ville Mustonen, Anne Farewell, Jonas Warringer, Leopold Parts, Danesh Moradigaravand
Published 2021-08-01

Identification of Intrinsic Drug Resistance and Its Biomarkers in High-Throughput Pharmacogenomic and CRISPR Screens

by Iñigo Ayestaran, Ana Galhoz, Elmar Spiegel, Ben Sidders, Jonathan R. Dry, Frank Dondelinger, Andreas Bender, Ultan McDermott, Francesco Iorio, Michael P. Menden
Published 2020-08-01

Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting

by Susie S.Y. Huang, Melanie Makhlouf, Eman H. AbouMoussa, Mayra L. Ruiz Tejada Segura, Lisa S. Mathew, Kun Wang, Man C. Leung, Damien Chaussabel, Darren W. Logan, Antonio Scialdone, Mathieu Garand, Luis R. Saraiva
Published 2020-10-01

Protocol for an interdisciplinary cross-sectional study investigating the social, biological and community-level drivers of antimicrobial resistance (AMR): Holistic Approach to Unr...

by Andy G Lynch, Joel Bazira, Derek J Sloan, Catherine Kansiime, Stella Neema, Wilber Sabiiti, Stephen H Gillespie, David M Aanensen, John Stelling, Alison Elliott, Benon B Asiimwe, John Kiiru, Stephen E Mshana, Katherine Keenan, Mike Kesby, Joseph R Mwanga, V Anne Smith, Alison Sandeman, Gibson E Kibiki, Matthew T G Holden, Martha F Mushi, Arun Gonzales Decano, Dominique L Green, John Mwaniki, Nyanda E Ntinginya
Published 2021-03-01

The global epidemiology of emerging Histoplasma species in recent years

by A.M. Rodrigues, M.A. Beale, F. Hagen, M.C. Fisher, P.P.D. Terra, S. de Hoog, R.S.N. Brilhante, R. de Aguiar Cordeiro, D. de Souza Collares Maia Castelo-Branco, M.F.G. Rocha, J.J.C. Sidrim, Z.P. de Camargo
Published 2020-09-01

Phenylpropanoids Are Connected to Cell Wall Fortification and Stress Tolerance in Avocado Somatic Embryogenesis

by Carol A. Olivares-García, Martín Mata-Rosas, Carolina Peña-Montes, Francisco Quiroz-Figueroa, Aldo Segura-Cabrera, Laura M. Shannon, Victor M. Loyola-Vargas, Juan L. Monribot-Villanueva, Jose M. Elizalde-Contreras, Enrique Ibarra-Laclette, Mónica Ramirez-Vázquez, José A. Guerrero-Analco, Eliel Ruiz-May
Published 2020-08-01

Accurate and fast identification of Campylobacter fetus in bulls by real-time PCR targeting a 16S rRNA gene sequence

by Rafael Delpiazzo, Maila Barcellos, Sofía Barros, Laura Betancor, Martín Fraga, Jorge Gil, Gregorio Iraola, Claudia Morsella, Fernando Paolicchi, Ruben Pérez, Franklin Riet-Correa, Margarita Sanguinetti, Alfonso Silva, Caroline da Silva Silveira, Lucía Calleros
Published 2021-03-01

Metagenomics-Based Proficiency Test of Smoked Salmon Spiked with a Mock Community

by Claudia Sala, Hanne Mordhorst, Josephine Grützke, Annika Brinkmann, Thomas N. Petersen, Casper Poulsen, Paul D. Cotter, Fiona Crispie, Richard J. Ellis, Gastone Castellani, Clara Amid, Mikhayil Hakhverdyan, Soizick Le Guyader, Gerardo Manfreda, Joël Mossong, Andreas Nitsche, Catherine Ragimbeau, Julien Schaeffer, Joergen Schlundt, Moon Y. F. Tay, Frank M. Aarestrup, Rene S. Hendriksen, Sünje Johanna Pamp, Alessandra De Cesare
Published 2020-11-01

Dense optical flow software to quantify cellular contractility

by Sérgio Scalzo, Marcelo Q.L. Afonso, Néli J. da Fonseca, Jr., Itamar C.G. Jesus, Ana Paula Alves, Carolina A.T. F. Mendonça, Vanessa P. Teixeira, Diogo Biagi, Estela Cruvinel, Anderson K. Santos, Kiany Miranda, Flavio A.M. Marques, Oscar N. Mesquita, Christopher Kushmerick, Maria José Campagnole-Santos, Ubirajara Agero, Silvia Guatimosim
Published 2021-08-01

Multi-Omic Data Integration Allows Baseline Immune Signatures to Predict Hepatitis B Vaccine Response in a Small Cohort

by Casey P. Shannon, Casey P. Shannon, Travis M. Blimkie, Rym Ben-Othman, Rym Ben-Othman, Nicole Gladish, Nelly Amenyogbe, Nelly Amenyogbe, Sibyl Drissler, Rachel D. Edgar, Rachel D. Edgar, Queenie Chan, Mel Krajden, Leonard J. Foster, Michael S. Kobor, William W. Mohn, Ryan R. Brinkman, Kim-Anh Le Cao, Richard H. Scheuermann, Richard H. Scheuermann, Richard H. Scheuermann, Scott J. Tebbutt, Scott J. Tebbutt, Scott J. Tebbutt, Robert E.W. Hancock, Wayne C. Koff, Tobias R. Kollmann, Tobias R. Kollmann, Manish Sadarangani, Manish Sadarangani, Amy Huei-Yi Lee
Published 2020-11-01

Towards a European health research and innovation cloud (HRIC)

by F. M. Aarestrup, A. Albeyatti, W. J. Armitage, C. Auffray, L. Augello, R. Balling, N. Benhabiles, G. Bertolini, J. G. Bjaalie, M. Black, N. Blomberg, P. Bogaert, M. Bubak, B. Claerhout, L. Clarke, B. De Meulder, G. D’Errico, A. Di Meglio, N. Forgo, C. Gans-Combe, A. E. Gray, I. Gut, A. Gyllenberg, G. Hemmrich-Stanisak, L. Hjorth, Y. Ioannidis, S. Jarmalaite, A. Kel, F. Kherif, J. O. Korbel, C. Larue, M. Laszlo, A. Maas, L. Magalhaes, I. Manneh-Vangramberen, E. Morley-Fletcher, C. Ohmann, P. Oksvold, N. P. Oxtoby, I. Perseil, V. Pezoulas, O. Riess, H. Riper, J. Roca, P. Rosenstiel, P. Sabatier, F. Sanz, M. Tayeb, G. Thomassen, J. Van Bussel, M. Van den Bulcke, H. Van Oyen
Published 2020-02-01

Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital...

by Uduak Okomo, PhD, Madikay Senghore, PhD, Saffiatou Darboe, MSc, Ebrima Bojang, MRes, Syed M A Zaman, PhD, Mohammad Jahangir Hossain, MBBS, Davis Nwakanma, PhD, Kirsty Le Doare, PhD, Kathryn E Holt, ProfPhD, Nina Judith Hos, MD, Joy E Lawn, ProfFMedSCi, Stephen D Bentley, PhD, Beate Kampmann, ProfPhD
Published 2020-07-01

Evidence generation and reproducibility in cell and gene therapy research: A call to action

by Mohamed Abou-el-Enein, Aris Angelis, Frederick R. Appelbaum, Nancy C. Andrews, Susan E. Bates, Arlene S. Bierman, Malcolm K. Brenner, Marina Cavazzana, Michael A. Caligiuri, Hans Clevers, Emer Cooke, George Q. Daley, Victor J. Dzau, Lee M. Ellis, Harvey V. Fineberg, Lawrence S.B. Goldstein, Stephen Gottschalk, Margaret A. Hamburg, Donald E. Ingber, Donald B. Kohn, Adrian R. Krainer, Marcela V. Maus, Peter Marks, Christine L. Mummery, Roderic I. Pettigrew, Joni L. Rutter, Sarah A. Teichmann, Andre Terzic, Fyodor D. Urnov, David A. Williams, Jedd D. Wolchok, Mark Lawler, Cameron J. Turtle, Gerhard Bauer, John P.A. Ioannidis
Published 2021-09-01

Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells

by Emily Welby, Jorn Lakowski, Valentina Di Foggia, Dimitri Budinger, Anai Gonzalez-Cordero, Aaron T.L. Lun, Michael Epstein, Aara Patel, Elisa Cuevas, Kamil Kruczek, Arifa Naeem, Federico Minneci, Mike Hubank, David T. Jones, John C. Marioni, Robin R. Ali, Jane C. Sowden
Published 2017-12-01

Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

by Yong H Woo, Hifzur Ansari, Thomas D Otto, Christen M Klinger, Martin Kolisko, Jan Michálek, Alka Saxena, Dhanasekaran Shanmugam, Annageldi Tayyrov, Alaguraj Veluchamy, Shahjahan Ali, Axel Bernal, Javier del Campo, Jaromír Cihlář, Pavel Flegontov, Sebastian G Gornik, Eva Hajdušková, Aleš Horák, Jan Janouškovec, Nicholas J Katris, Fred D Mast, Diego Miranda-Saavedra, Tobias Mourier, Raeece Naeem, Mridul Nair, Aswini K Panigrahi, Neil D Rawlings, Eriko Padron-Regalado, Abhinay Ramaprasad, Nadira Samad, Aleš Tomčala, Jon Wilkes, Daniel E Neafsey, Christian Doerig, Chris Bowler, Patrick J Keeling, David S Roos, Joel B Dacks, Thomas J Templeton, Ross F Waller, Julius Lukeš, Miroslav Oborník, Arnab Pain
Published 2015-07-01

A Deep Learning Approach Validates Genetic Risk Factors for Late Toxicity After Prostate Cancer Radiotherapy in a REQUITE Multi-National Cohort

by Michela Carlotta Massi, Michela Carlotta Massi, Francesca Gasperoni, Francesca Ieva, Francesca Ieva, Francesca Ieva, Anna Maria Paganoni, Anna Maria Paganoni, Anna Maria Paganoni, Paolo Zunino, Andrea Manzoni, Nicola Rares Franco, Liv Veldeman, Liv Veldeman, Piet Ost, Piet Ost, Valérie Fonteyne, Valérie Fonteyne, Christopher J. Talbot, Tim Rattay, Adam Webb, Paul R. Symonds, Kerstie Johnson, Maarten Lambrecht, Karin Haustermans, Gert De Meerleer, Dirk de Ruysscher, Dirk de Ruysscher, Ben Vanneste, Evert Van Limbergen, Evert Van Limbergen, Ananya Choudhury, Rebecca M. Elliott, Elena Sperk, Carsten Herskind, Marlon R. Veldwijk, Barbara Avuzzi, Tommaso Giandini, Riccardo Valdagni, Riccardo Valdagni, Riccardo Valdagni, Alessandro Cicchetti, David Azria, Marie-Pierre Farcy Jacquet, Barry S. Rosenstein, Barry S. Rosenstein, Richard G. Stock, Kayla Collado, Ana Vega, Ana Vega, Ana Vega, Miguel Elías Aguado-Barrera, Miguel Elías Aguado-Barrera, Patricia Calvo, Patricia Calvo, Alison M. Dunning, Laura Fachal, Laura Fachal, Sarah L. Kerns, Debbie Payne, Jenny Chang-Claude, Jenny Chang-Claude, Petra Seibold, Catharine M. L. West, Tiziana Rancati
Published 2020-10-01