Spatially and Temporally Regulated NRF2 Gene Therapy Using Mcp-1 Promoter in Retinal Ganglion Cell Injury

by Kosuke Fujita, Koji M. Nishiguchi, Yukihiro Shiga, Toru Nakazawa
Published 2017-06-01

The relationship between glutathione levels in leukocytes and ocular clinical parameters in glaucoma.

by Takeshi Yabana, Kota Sato, Yukihiro Shiga, Noriko Himori, Kazuko Omodaka, Toru Nakazawa
Published 2019-01-01

Age- and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation.

by Naoko Aizawa, Hiroshi Kunikata, Fumihiko Nitta, Yukihiro Shiga, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa
Published 2016-01-01

Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage

by Yoshimi Asano, Noriko Himori, Hiroshi Kunikata, Mai Yamazaki, Yukihiro Shiga, Kazuko Omodaka, Hidetoshi Takahashi, Toru Nakazawa
Published 2017-08-01

Comparison of Machine-Learning Classification Models for Glaucoma Management

by Guangzhou An, Kazuko Omodaka, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Tsutomu Kikawa, Toru Nakazawa, Hideo Yokota, Masahiro Akiba
Published 2018-01-01

Classification of optic disc shape in glaucoma using machine learning based on quantified ocular parameters.

by Kazuko Omodaka, Guangzhou An, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Tsutomu Kikawa, Hidetoshi Takahashi, Hideo Yokota, Masahiro Akiba, Toru Nakazawa
Published 2017-01-01

Glaucoma Diagnosis with Machine Learning Based on Optical Coherence Tomography and Color Fundus Images

by Guangzhou An, Kazuko Omodaka, Kazuki Hashimoto, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Tsutomu Kikawa, Hideo Yokota, Masahiro Akiba, Toru Nakazawa
Published 2019-01-01

The effectiveness of colchicine combined with mitomycin C to prolong bleb function in trabeculectomy in rabbits.

by Taiki Kokubun, Kotaro Yamamoto, Kota Sato, Takahiro Akaishi, Atsushi Shimazaki, Masatsugu Nakamura, Yukihiro Shiga, Satoru Tsuda, Kazuko Omodaka, Toru Nakazawa
Published 2019-01-01

3D evaluation of the lamina cribrosa with swept-source optical coherence tomography in normal tension glaucoma.

by Kazuko Omodaka, Takaaki Horii, Seri Takahashi, Tsutomu Kikawa, Akiko Matsumoto, Yukihiro Shiga, Kazuichi Maruyama, Tetsuya Yuasa, Masahiro Akiba, Toru Nakazawa
Published 2015-01-01

Pilot study for three-dimensional assessment of laminar pore structure in patients with glaucoma, as measured with swept source optical coherence tomography.

by Kazuko Omodaka, Shigeto Maekawa, Guangzhou An, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Tsutomu Kikawa, Hidetoshi Takahashi, Hideo Yokota, Masahiro Akiba, Toru Nakazawa
Published 2018-01-01

OCT-Based Quantification and Classification of Optic Disc Structure in Glaucoma Patients.

by Naoko Takada, Kazuko Omodaka, Tsutomu Kikawa, Airi Takagi, Akiko Matsumoto, Yu Yokoyama, Yukihiro Shiga, Kazuichi Maruyama, Hidetoshi Takahashi, Masahiro Akiba, Toru Nakazawa
Published 2016-01-01

Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma.

by Kazuko Omodaka, Tsutomu Kikawa, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Haruka Sato, Junko Ohuchi, Akiko Matsumoto, Hidetoshi Takahashi, Masahiro Akiba, Toru Nakazawa
Published 2017-01-01

Preperimetric Glaucoma Prospective Observational Study (PPGPS): Design, baseline characteristics, and therapeutic effect of tafluprost in preperimetric glaucoma eye.

by Naoko Aizawa, Hiroshi Kunikata, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Tomoki Yasui, Keiichi Kato, Hiroaki Kurashima, Etsuyo Miyamoto, Masayo Hashimoto, Toru Nakazawa
Published 2017-01-01

The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation

by Shigeto Maekawa, Kota Sato, Kosuke Fujita, Reiko Daigaku, Hiroshi Tawarayama, Namie Murayama, Satoru Moritoh, Takeshi Yabana, Yukihiro Shiga, Kazuko Omodaka, Kazuichi Maruyama, Koji M. Nishiguchi, Toru Nakazawa
Published 2017-07-01

The Traditional Kampo Medicine Tokishakuyakusan Increases Ocular Blood Flow in Healthy Subjects

by Shin Takayama, Yukihiro Shiga, Taiki Kokubun, Hideyuki Konno, Noriko Himori, Morin Ryu, Takehiro Numata, Soichiro Kaneko, Hitoshi Kuroda, Junichi Tanaka, Seiki Kanemura, Tadashi Ishii, Nobuo Yaegashi, Toru Nakazawa
Published 2014-01-01

Additive effects of genetic variants associated with intraocular pressure in primary open-angle glaucoma.

by Fumihiko Mabuchi, Nakako Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Hiroyuki Iijima, Zentaro Yamagata, Mitsuko Takamoto, Makoto Aihara, Takeshi Iwata, Kazuhide Kawase, Yukihiro Shiga, Koji M Nishiguchi, Toru Nakazawa, Mineo Ozaki, Makoto Araie, Japan Glaucoma Society Omics Group (JGS-OG)
Published 2017-01-01

Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7.

by Yukihiro Shiga, Koji M Nishiguchi, Yosuke Kawai, Kaname Kojima, Kota Sato, Kosuke Fujita, Mai Takahashi, Kazuko Omodaka, Makoto Araie, Kenji Kashiwagi, Makoto Aihara, Takeshi Iwata, Fumihiko Mabuchi, Mitsuko Takamoto, Mineo Ozaki, Kazuhide Kawase, Nobuo Fuse, Masayuki Yamamoto, Jun Yasuda, Masao Nagasaki, Toru Nakazawa, Japan Glaucoma Society Omics Group (JGS-OG)
Published 2017-01-01

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

by Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P. Khawaja, Sarah Pendergrass, Xikun Han, Jue Sheng Ong, Alex W. Hewitt, Ayellet V. Segrè, John M. Rouhana, Andrew R. Hamel, Robert P. Igo, Helene Choquet, Ayub Qassim, Navya S. Josyula, Jessica N. Cooke Bailey, Pieter W. M. Bonnemaijer, Adriana Iglesias, Owen M. Siggs, Terri L. Young, Veronique Vitart, Alberta A. H. J. Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B. Melles, K. Saidas Nair, Robert Luben, Mark Simcoe, Nishani Amersinghe, Angela J. Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi-Song Rong, Tin Aung, Eranga Nishanthie Vithana, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K. Lupton, Nicholas G. Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E. Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J. Foster, Peng T. Khaw, James E. Morgan, Nicholas G. Strouthidis, Peter Kraft, Jae H. Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J. Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L. Haines, Chris Hammond, Louis R. Pasquale, Caroline C. W. Klaver, Michael Hauser, Chiea Chuen Khor, David A. Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E. Craig, Stuart MacGregor, Janey L. Wiggs
Published 2021-02-01