Early life diet conditions the molecular response to post-weaning protein restriction in the mouse

by Amy F. Danson, Sarah J. Marzi, Robert Lowe, Michelle L. Holland, Vardhman K. Rakyan
Published 2018-05-01

Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.

by Marwa H Saied, Jacek Marzec, Sabah Khalid, Paul Smith, Thomas A Down, Vardhman K Rakyan, Gael Molloy, Manoj Raghavan, Silvana Debernardi, Bryan D Young
Published 2012-01-01

The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations.

by Fredrika Åsenius, Tyler J Gorrie-Stone, Ama Brew, Yasmin Panchbhaya, Elizabeth Williamson, Leonard C Schalkwyk, Vardhman K Rakyan, Michelle L Holland, Sarah J Marzi, David J Williams
Published 2020-10-01

DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project.

by Vardhman K Rakyan, Thomas Hildmann, Karen L Novik, Jörn Lewin, Jörg Tost, Antony V Cox, T Dan Andrews, Kevin L Howe, Thomas Otto, Alexander Olek, Judith Fischer, Ivo G Gut, Kurt Berlin, Stephan Beck
Published 2004-12-01

Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species

by Robert Lowe, Carl Barton, Christopher A. Jenkins, Christina Ernst, Oliver Forman, Denise S. Fernandez-Twinn, Christoph Bock, Stephen J. Rossiter, Chris G. Faulkes, Susan E. Ozanne, Lutz Walter, Duncan T. Odom, Cathryn Mellersh, Vardhman K. Rakyan
Published 2018-02-01

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

by Matthias Thurner, Martijn van de Bunt, Jason M Torres, Anubha Mahajan, Vibe Nylander, Amanda J Bennett, Kyle J Gaulton, Amy Barrett, Carla Burrows, Christopher G Bell, Robert Lowe, Stephan Beck, Vardhman K Rakyan, Anna L Gloyn, Mark I McCarthy
Published 2018-02-01

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

by Vardhman K Rakyan, Huriya Beyan, Thomas A Down, Mohammed I Hawa, Siarhei Maslau, Deeqo Aden, Antoine Daunay, Florence Busato, Charles A Mein, Burkhard Manfras, Kerith-Rae M Dias, Christopher G Bell, Jörg Tost, Bernhard O Boehm, Stephan Beck, R David Leslie
Published 2011-09-01

DNA methylation aging clocks: challenges and recommendations

by Christopher G. Bell, Robert Lowe, Peter D. Adams, Andrea A. Baccarelli, Stephan Beck, Jordana T. Bell, Brock C. Christensen, Vadim N. Gladyshev, Bastiaan T. Heijmans, Steve Horvath, Trey Ideker, Jean-Pierre J. Issa, Karl T. Kelsey, Riccardo E. Marioni, Wolf Reik, Caroline L. Relton, Leonard C. Schalkwyk, Andrew E. Teschendorff, Wolfgang Wagner, Kang Zhang, Vardhman K. Rakyan
Published 2019-11-01

Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.

by Christopher G Bell, Sarah Finer, Cecilia M Lindgren, Gareth A Wilson, Vardhman K Rakyan, Andrew E Teschendorff, Pelin Akan, Elia Stupka, Thomas A Down, Inga Prokopenko, Ian M Morison, Jonathan Mill, Ruth Pidsley, International Type 2 Diabetes 1q Consortium, Panos Deloukas, Timothy M Frayling, Andrew T Hattersley, Mark I McCarthy, Stephan Beck, Graham A Hitman
Published 2010-11-01

Increased DNA methylation variability in type 1 diabetes across three immune effector cell types

by Dirk S. Paul, Andrew E. Teschendorff, Mary A.N. Dang, Robert Lowe, Mohammed I. Hawa, Simone Ecker, Huriya Beyan, Stephanie Cunningham, Alexandra R. Fouts, Anita Ramelius, Frances Burden, Samantha Farrow, Sophia Rowlston, Karola Rehnstrom, Mattia Frontini, Kate Downes, Stephan Busche, Warren A. Cheung, Bing Ge, Marie-Michelle Simon, David Bujold, Tony Kwan, Guillaume Bourque, Avik Datta, Ernesto Lowy, Laura Clarke, Paul Flicek, Emanuele Libertini, Simon Heath, Marta Gut, Ivo G Gut, Willem H. Ouwehand, Tomi Pastinen, Nicole Soranzo, Sabine E. Hofer, Beate Karges, Thomas Meissner, Bernhard O. Boehm, Corrado Cilio, Helena Elding Larsson, Åke Lernmark, Andrea K. Steck, Vardhman K. Rakyan, Stephan Beck, R. David Leslie
Published 2016-11-01