The use of tail-anchored protein chimeras to enhance liposomal cargo delivery.

by Abbi Abdelrehim, Lior Shaltiel, Ling Zhang, Yechezkel Barenholz, Stephen High, Lynda K Harris
Published 2019-01-01

Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis

by Peristera Roboti, Sarah O’Keefe, Kwabena B. Duah, Wei Q. Shi, Stephen High
Published 2021-06-01

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

by Sarah Haßdenteufel, Nicholas Johnson, Adrienne W. Paton, James C. Paton, Stephen High, Richard Zimmermann
Published 2018-05-01

An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum

by Sarah O’Keefe, Guanghui Zong, Kwabena B. Duah, Lauren E. Andrews, Wei Q. Shi, Stephen High
Published 2021-07-01

The signal sequence influences post-translational ER translocation at distinct stages.

by Nicholas Johnson, Sarah Haßdenteufel, Melanie Theis, Adrienne W Paton, James C Paton, Richard Zimmermann, Stephen High
Published 2013-01-01

The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.

by Belinda S Hall, Kirsti Hill, Michael McKenna, Joy Ogbechi, Stephen High, Anne E Willis, Rachel E Simmonds
Published 2014-04-01

The association of BAG6 with SGTA and tail-anchored proteins.

by Pawel Leznicki, Quentin P Roebuck, Lydia Wunderley, Anne Clancy, Ewelina M Krysztofinska, Rivka L Isaacson, Jim Warwicker, Blanche Schwappach, Stephen High
Published 2013-01-01

Distinct Requirements for Tail-Anchored Membrane Protein Biogenesis in Escherichia coli

by Markus Peschke, Mélanie Le Goff, Gregory M. Koningstein, Norbert O. Vischer, Abbi Abdel-Rehim, Stephen High, Peter van Ulsen, Joen Luirink
Published 2019-10-01

Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.

by Chao Sun, Peristera Roboti, Marjo-Riitta Puumalainen, Mårten Fryknäs, Xin Wang, Padraig D'Arcy, Malin Hult, Stephen High, Stig Linder, Eileithyia Swanton
Published 2014-01-01

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways.

by Mina-Olga Aletrari, Craig McKibbin, Helen Williams, Vidya Pawar, Paola Pietroni, J Michael Lord, Sabine L Flitsch, Roger Whitehead, Eileithyia Swanton, Stephen High, Robert A Spooner
Published 2011-01-01

Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle.

by Ruth Steinberg, Andrea Origi, Ana Natriashvili, Pinku Sarmah, Mariya Licheva, Princess M Walker, Claudine Kraft, Stephen High, Joen Luirink, Wei Q Shi, Martin Helmstädter, Maximilian H Ulbrich, Hans-Georg Koch
Published 2020-09-01

Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control

by Santiago Martínez-Lumbreras, Ewelina M. Krysztofinska, Arjun Thapaliya, Alessandro Spilotros, Dijana Matak-Vinkovic, Enrico Salvadori, Peristera Roboti, Yvonne Nyathi, Janina H. Muench, Maxie M. Roessler, Dmitri I. Svergun, Stephen High, Rivka L. Isaacson
Published 2018-07-01

Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A.

by John F Darby, Ewelina M Krysztofinska, Peter J Simpson, Aline C Simon, Pawel Leznicki, Newran Sriskandarajah, David S Bishop, Lisa R Hale, Caterina Alfano, Maria R Conte, Santiago Martínez-Lumbreras, Arjun Thapaliya, Stephen High, Rivka L Isaacson
Published 2014-01-01