Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19

by Valentino Clemente, Padraig D’Arcy, Martina Bazzaro
Published 2020-05-01

Regulation of TRAIL-Receptor Expression by the Ubiquitin-Proteasome System

by Dhifaf Sarhan, Padraig D'Arcy, Andreas Lundqvist
Published 2014-10-01

Oncogenic functions of the cancer-testis antigen SSX on the proliferation, survival, and signaling pathways of cancer cells.

by Padraig D'Arcy, Wessen Maruwge, Barry Wolahan, Limin Ma, Bertha Brodin
Published 2014-01-01

Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15.

by Arjan Mofers, Paola Perego, Karthik Selvaraju, Laura Gatti, Joachim Gullbo, Stig Linder, Padraig D'Arcy
Published 2019-01-01

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

by Xiaonan Zhang, Belén Espinosa, Amir Ata Saei, Padraig D'Arcy, Roman A. Zubarev, Stig Linder
Published 2019-01-01

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

by Xiaonan Zhang, Angelo de Milito, Maria Hägg Olofsson, Joachim Gullbo, Padraig D’Arcy, Stig Linder
Published 2015-11-01

Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570

by Paola Pellegrini, Karthik Selvaraju, Elena Faustini, Arjan Mofers, Xiaonan Zhang, Jens Ternerot, Alice Schubert, Stig Linder, Pádraig D′Arcy
Published 2020-07-01

Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System

by Karthik Selvaraju, Kourosh Lotfi, Johannes Gubat, Maria Miquel, Amanda Nilsson, Julia Hill, Lasse D. Jensen, Stig Linder, Pádraig D’Arcy
Published 2021-09-01

Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.

by Chao Sun, Peristera Roboti, Marjo-Riitta Puumalainen, Mårten Fryknäs, Xin Wang, Padraig D'Arcy, Malin Hult, Stephen High, Stig Linder, Eileithyia Swanton
Published 2014-01-01

A drug screening assay on cancer cells chronically adapted to acidosis

by Paola Pellegrini, Jason T. Serviss, Thomas Lundbäck, Nicolo Bancaro, Magdalena Mazurkiewicz, Iryna Kolosenko, Di Yu, Martin Haraldsson, Padraig D’Arcy, Stig Linder, Angelo De Milito
Published 2018-09-01