Drug Development Targeting the Ubiquitin–Proteasome System (UPS) for the Treatment of Human Cancers

by Xiaonan Zhang, Stig Linder, Martina Bazzaro
Published 2020-04-01

Antiproliferative Effects of the Natural Oxadiazine Nocuolin A Are Associated With Impairment of Mitochondrial Oxidative Phosphorylation

by Maria Lígia Sousa, Maria Lígia Sousa, Marco Preto, Vítor Vasconcelos, Vítor Vasconcelos, Stig Linder, Stig Linder, Ralph Urbatzka
Published 2019-04-01

Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

by Xiaonan Zhang, Mihir Shetty, Valentino Clemente, Stig Linder, Martina Bazzaro
Published 2021-04-01

Pseudomonas aeruginosa N-3-Oxo-Dodecanoyl-Homoserine Lactone Impacts Mitochondrial Networks Morphology, Energetics, and Proteome in Host Cells

by Henrik Josephson, Maria Ntzouni, Camilla Skoglund, Stig Linder, Maria V. Turkina, Elena Vikström
Published 2020-05-01

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.

by Walid Fayad, Mårten Fryknäs, Slavica Brnjic, Maria Hägg Olofsson, Rolf Larsson, Stig Linder
Published 2009-10-01

Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer

by Edith Emmings, Sally Mullany, Zenas Chang, Charles N. Landen, Stig Linder, Martina Bazzaro
Published 2019-01-01

Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15.

by Arjan Mofers, Paola Perego, Karthik Selvaraju, Laura Gatti, Joachim Gullbo, Stig Linder, Padraig D'Arcy
Published 2019-01-01

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

by Xiaonan Zhang, Belén Espinosa, Amir Ata Saei, Padraig D'Arcy, Roman A. Zubarev, Stig Linder
Published 2019-01-01

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

by Xiaonan Zhang, Angelo de Milito, Maria Hägg Olofsson, Joachim Gullbo, Padraig D’Arcy, Stig Linder
Published 2015-11-01

Polypeptide Expression in Prostate Hyperplasia and Prostate Adenocarcinoma

by Ayodele Alaiya, Uwe Roblick, Lars Egevad, Adelaide Carlsson, Bo Franzén, Daniela Volz, Sören Huwendiek, Stig Linder, Gert Auer
Published 2000-01-01

Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570

by Paola Pellegrini, Karthik Selvaraju, Elena Faustini, Arjan Mofers, Xiaonan Zhang, Jens Ternerot, Alice Schubert, Stig Linder, Pádraig D′Arcy
Published 2020-07-01

Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System

by Karthik Selvaraju, Kourosh Lotfi, Johannes Gubat, Maria Miquel, Amanda Nilsson, Julia Hill, Lasse D. Jensen, Stig Linder, Pádraig D’Arcy
Published 2021-09-01

Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.

by Chao Sun, Peristera Roboti, Marjo-Riitta Puumalainen, Mårten Fryknäs, Xin Wang, Padraig D'Arcy, Malin Hult, Stephen High, Stig Linder, Eileithyia Swanton
Published 2014-01-01

Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action.

by Tiago Ribeiro, Filipa Lemos, Marco Preto, Joana Azevedo, Maria Lígia Sousa, Pedro N Leão, Alexandre Campos, Stig Linder, Rui Vitorino, Vitor Vasconcelos, Ralph Urbatzka
Published 2017-01-01

A drug screening assay on cancer cells chronically adapted to acidosis

by Paola Pellegrini, Jason T. Serviss, Thomas Lundbäck, Nicolo Bancaro, Magdalena Mazurkiewicz, Iryna Kolosenko, Di Yu, Martin Haraldsson, Padraig D’Arcy, Stig Linder, Angelo De Milito
Published 2018-09-01

Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study

by Ola Brodin, Staffan Eksborg, Marita Wallenberg, Charlotte Asker-Hagelberg, Erik H. Larsen, Dag Mohlkert, Clara Lenneby-Helleday, Hans Jacobsson, Stig Linder, Sougat Misra, Mikael Björnstedt
Published 2015-06-01

Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts.

by Qing Cheng, Li Lu, Jonas Grafström, Maria Hägg Olofsson, Jan-Olov Thorell, Erik Samén, Katarina Johansson, Hanna-Stina Ahlzén, Sharon Stone-Elander, Stig Linder, Elias S J Arnér, Sel-tag Imaging Project
Published 2012-01-01