A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

by Guang Yang, Danielle S. Murashige, Sean J. Humphrey, David E. James
Published 2015-08-01

Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion

by Francesca Sacco, Sean J. Humphrey, Jürgen Cox, Marcel Mischnik, Anke Schulte, Thomas Klabunde, Matthias Schäfer, Matthias Mann
Published 2016-11-01

PhosR enables processing and functional analysis of phosphoproteomic data

by Hani Jieun Kim, Taiyun Kim, Nolan J. Hoffman, Di Xiao, David E. James, Sean J. Humphrey, Pengyi Yang
Published 2021-02-01

Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion

by Elise J. Needham, Sean J. Humphrey, Kristen C. Cooke, Daniel J. Fazakerley, Xiaowen Duan, Benjamin L. Parker, David E. James
Published 2019-11-01

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation

by Jacqueline Stöckli, Armella Zadoorian, Kristen C. Cooke, Vinita Deshpande, Belinda Yau, Gaia Herrmann, Melkam A. Kebede, Sean J. Humphrey, David E. James
Published 2019-07-01

Correction: Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies.

by Westa Domanova, James R Krycer, Rima Chaudhuri, Pengyi Yang, Fatemeh Vafaee, Daniel J Fazakerley, Sean J Humphrey, David E James, Zdenka Kuncic
Published 2017-01-01

Corrigendum to ‘ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation’ [Molecular Metabolism 25 (2019) p.83–94]

by Jacqueline Stöckli, Armella Zadoorian, Kristen C. Cooke, Vinita Deshpande, Belinda Yau, Gaia Herrmann, Melkam A. Kebede, Sean J. Humphrey, David E. James
Published 2021-06-01

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes

by Annabel Y. Minard, Shi-Xiong Tan, Pengyi Yang, Daniel J. Fazakerley, Westa Domanova, Benjamin L. Parker, Sean J. Humphrey, Raja Jothi, Jacqueline Stöckli, David E. James
Published 2016-09-01

A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans

by Lenka Halova, David Cobley, Mirita Franz-Wachtel, Tingting Wang, Kaitlin R. Morrison, Karsten Krug, Nicolas Nalpas, Boris Maček, Iain M. Hagan, Sean J. Humphrey, Janni Petersen
Published 2021-04-01

Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

by Ariadna Recasens, Sean J. Humphrey, Michael Ellis, Monira Hoque, Ramzi H. Abbassi, Brianna Chen, Mitchell Longworth, Elise J. Needham, David E. James, Terrance G. Johns, Bryan W. Day, Michael Kassiou, Pengyi Yang, Lenka Munoz
Published 2021-04-01

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

by Alison L Kearney, Dougall M Norris, Milad Ghomlaghi, Martin Kin Lok Wong, Sean J Humphrey, Luke Carroll, Guang Yang, Kristen C Cooke, Pengyi Yang, Thomas A Geddes, Sungyoung Shin, Daniel J Fazakerley, Lan K Nguyen, David E James, James G Burchfield
Published 2021-07-01

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

by James R. Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Daniel J. Fazakerley, Lake-Ee Quek, Richard Scalzo, Satoshi Ohno, Mark P. Hodson, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Westa Domanova, Benjamin L. Parker, Marin E. Nelson, Sean J. Humphrey, Nigel Turner, Kyle L. Hoehn, Gregory J. Cooney, Tomoyoshi Soga, Shinya Kuroda, David E. James
Published 2017-12-01

Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet

by Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V. Carr, Julian Van Gerwen, Elise J. Needham, Dillon Jevon, Sing-Young Chen, Kyle L. Hoehn, Amanda E. Brandon, Laurance Macia, Gregory J. Cooney, Michael R. Shortreed, Lloyd M. Smith, Mark P. Keller, Peter Thorn, Mark Larance, David E. James, Sean J. Humphrey, Melkam A. Kebede
Published 2021-10-01

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt

by Zhiduan Su, James G. Burchfield, Pengyi Yang, Sean J. Humphrey, Guang Yang, Deanne Francis, Sabina Yasmin, Sung-Young Shin, Dougall M. Norris, Alison L. Kearney, Miro A. Astore, Jonathan Scavuzzo, Kelsey H. Fisher-Wellman, Qiao-Ping Wang, Benjamin L. Parker, G. Gregory Neely, Fatemeh Vafaee, Joyce Chiu, Reichelle Yeo, Philip J. Hogg, Daniel J. Fazakerley, Lan K. Nguyen, Serdar Kuyucak, David E. James
Published 2019-12-01

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

by Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Published 2018-02-01