Muscle and adipose tissue insulin resistance: malady without mechanism?

by Daniel J. Fazakerley, James R. Krycer, Alison L. Kearney, Samantha L. Hocking, David E. James
Published 2019-10-01

Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion

by Elise J. Needham, Sean J. Humphrey, Kristen C. Cooke, Daniel J. Fazakerley, Xiaowen Duan, Benjamin L. Parker, David E. James
Published 2019-11-01

The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.

by Rachael Fletcher, Christopher Gribben, Xiuquan Ma, James G Burchfield, Kristen C Thomas, James R Krycer, David E James, Daniel J Fazakerley
Published 2014-01-01

Correction: Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies.

by Westa Domanova, James R Krycer, Rima Chaudhuri, Pengyi Yang, Fatemeh Vafaee, Daniel J Fazakerley, Sean J Humphrey, David E James, Zdenka Kuncic
Published 2017-01-01

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes

by Annabel Y. Minard, Shi-Xiong Tan, Pengyi Yang, Daniel J. Fazakerley, Westa Domanova, Benjamin L. Parker, Sean J. Humphrey, Raja Jothi, Jacqueline Stöckli, David E. James
Published 2016-09-01

Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression

by Dougall Norris, Pengyi Yang, Sung-Young Shin, Alison L. Kearney, Hani Jieun Kim, Thomas Geddes, Alistair M. Senior, Daniel J. Fazakerley, Lan K. Nguyen, David E. James, James G. Burchfield
Published 2021-02-01

Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

by Lake-Ee Quek, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W. Locasale, Tomoyoshi Soga, David E. James, Shinya Kuroda
Published 2020-12-01

Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

by Lake-Ee Quek, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W. Locasale, Tomoyoshi Soga, David E. James, Shinya Kuroda
Published 2020-02-01

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

by Alison L Kearney, Dougall M Norris, Milad Ghomlaghi, Martin Kin Lok Wong, Sean J Humphrey, Luke Carroll, Guang Yang, Kristen C Cooke, Pengyi Yang, Thomas A Geddes, Sungyoung Shin, Daniel J Fazakerley, Lan K Nguyen, David E James, James G Burchfield
Published 2021-07-01

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

by Maximilian Kleinert, Benjamin L. Parker, Rima Chaudhuri, Daniel J. Fazakerley, Annette Serup, Kristen C. Thomas, James R. Krycer, Lykke Sylow, Andreas M. Fritzen, Nolan J. Hoffman, Jacob Jeppesen, Peter Schjerling, Markus A. Ruegg, Bente Kiens, David E. James, Erik A. Richter
Published 2016-08-01

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

by James R. Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Daniel J. Fazakerley, Lake-Ee Quek, Richard Scalzo, Satoshi Ohno, Mark P. Hodson, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Westa Domanova, Benjamin L. Parker, Marin E. Nelson, Sean J. Humphrey, Nigel Turner, Kyle L. Hoehn, Gregory J. Cooney, Tomoyoshi Soga, Shinya Kuroda, David E. James
Published 2017-12-01

Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

by Anita Ayer, Daniel J. Fazakerley, Cacang Suarna, Ghassan J. Maghzal, Diba Sheipouri, Kevin J. Lee, Michelle C. Bradley, Lucía Fernández-del-Rio, Sergey Tumanov, Stephanie MY. Kong, Jelske N. van der Veen, Andrian Yang, Joshua W.K. Ho, Steven G. Clarke, David E. James, Ian W. Dawes, Dennis E. Vance, Catherine F. Clarke, René L. Jacobs, Roland Stocker
Published 2021-10-01

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt

by Zhiduan Su, James G. Burchfield, Pengyi Yang, Sean J. Humphrey, Guang Yang, Deanne Francis, Sabina Yasmin, Sung-Young Shin, Dougall M. Norris, Alison L. Kearney, Miro A. Astore, Jonathan Scavuzzo, Kelsey H. Fisher-Wellman, Qiao-Ping Wang, Benjamin L. Parker, G. Gregory Neely, Fatemeh Vafaee, Joyce Chiu, Reichelle Yeo, Philip J. Hogg, Daniel J. Fazakerley, Lan K. Nguyen, Serdar Kuyucak, David E. James
Published 2019-12-01

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

by Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Published 2018-02-01

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress

by Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. Santos, Kate GR. Quinlan, Nigel Turner, Daniel J. Fazakerley, Naresh Kumar, Kyle L. Hoehn
Published 2020-01-01