The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis.

by Rhianna C Laker, Evan P Taddeo, Yasir N Akhtar, Mei Zhang, Kyle L Hoehn, Zhen Yan
Published 2016-01-01

Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses.

by Jang Eun Lee, Matthew C Walsh, Kyle L Hoehn, David E James, E John Wherry, Yongwon Choi
Published 2015-01-01

Serial MRI Imaging Reveals Minimal Impact of Ketogenic Diet on Established Liver Tumor Growth

by Frances L. Byrne, Stefan R. Hargett, Sujoy Lahiri, R. Jack Roy, Stuart S. Berr, Stephen H. Caldwell, Kyle L. Hoehn
Published 2018-09-01

Delivering bioactive cyclic peptides that target Hsp90 as prodrugs

by Yuantao Huo, Laura K. Buckton, Jack L. Bennett, Eloise C. Smith, Frances L. Byrne, Kyle L. Hoehn, Marwa N. Rahimi, Shelli R. McAlpine
Published 2019-01-01

Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3

by Evan P. Taddeo, Stefan R. Hargett, Sujoy Lahiri, Marin E. Nelson, Jason A. Liao, Chien Li, Jill K. Slack-Davis, Jose L. Tomsig, Kevin R. Lynch, Zhen Yan, Thurl E. Harris, Kyle L. Hoehn
Published 2017-03-01

Distinct Roles for Intracellular and Extracellular Lipids in Hepatitis C Virus Infection.

by Sowmya Narayanan, Albert H Nieh, Brandon M Kenwood, Christine A Davis, Annie-Carole Tosello-Trampont, Tedd D Elich, Steven D Breazeale, Eric Ward, Richard J Anderson, Stephen H Caldwell, Kyle L Hoehn, Young S Hahn
Published 2016-01-01

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

by Alexander J. Knights, Emily J. Vohralik, Peter J. Houweling, Elizabeth S. Stout, Laura J. Norton, Stephanie J. Alexopoulos, Jinfen. J. Yik, Hanapi Mat Jusoh, Ellen M. Olzomer, Kim S. Bell-Anderson, Kathryn N. North, Kyle L. Hoehn, Merlin Crossley, Kate G. R. Quinlan
Published 2020-06-01

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

by Marin E. Nelson, Sujoy Lahiri, Jenny D. Y. Chow, Frances L. Byrne, Stefan R. Hargett, David S. Breen, Ellen M. Olzomer, Lindsay E. Wu, Gregory J. Cooney, Nigel Turner, David E. James, Jill K. Slack-Davis, Carolin Lackner, Stephen H. Caldwell, Kyle L. Hoehn
Published 2017-03-01

Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15

by Elizabeth R. M. Zunica, Christopher L. Axelrod, Eunhan Cho, Guillaume Spielmann, Gangarao Davuluri, Stephanie J. Alexopoulos, Martina Beretta, Kyle L. Hoehn, Wagner S. Dantas, Krisztian Stadler, William T. King, Kathryn Pergola, Brian A. Irving, Ingeborg M. Langohr, Shengping Yang, Charles L. Hoppel, L. Anne Gilmore, John P. Kirwan
Published 2021-10-01

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

by James R. Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Daniel J. Fazakerley, Lake-Ee Quek, Richard Scalzo, Satoshi Ohno, Mark P. Hodson, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Westa Domanova, Benjamin L. Parker, Marin E. Nelson, Sean J. Humphrey, Nigel Turner, Kyle L. Hoehn, Gregory J. Cooney, Tomoyoshi Soga, Shinya Kuroda, David E. James
Published 2017-12-01

BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control

by Christopher L Axelrod, William T King, Gangarao Davuluri, Robert C Noland, Jacob Hall, Michaela Hull, Wagner S Dantas, Elizabeth RM Zunica, Stephanie J Alexopoulos, Kyle L Hoehn, Ingeborg Langohr, Krisztian Stadler, Haylee Doyle, Eva Schmidt, Stephan Nieuwoudt, Kelly Fitzgerald, Kathryn Pergola, Hisashi Fujioka, Jacob T Mey, Ciaran Fealy, Anny Mulya, Robbie Beyl, Charles L Hoppel, John P Kirwan
Published 2020-07-01

Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet

by Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V. Carr, Julian Van Gerwen, Elise J. Needham, Dillon Jevon, Sing-Young Chen, Kyle L. Hoehn, Amanda E. Brandon, Laurance Macia, Gregory J. Cooney, Michael R. Shortreed, Lloyd M. Smith, Mark P. Keller, Peter Thorn, Mark Larance, David E. James, Sean J. Humphrey, Melkam A. Kebede
Published 2021-10-01

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

by Stephanie J. Alexopoulos, Sing-Young Chen, Amanda E. Brandon, Joseph M. Salamoun, Frances L. Byrne, Christopher J. Garcia, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Ashleigh M. Philp, Stefan R. Hargett, Robert T. Lawrence, Brendan Lee, James Sligar, Pascal Carrive, Simon P. Tucker, Andrew Philp, Carolin Lackner, Nigel Turner, Gregory J. Cooney, Webster L. Santos, Kyle L. Hoehn
Published 2020-05-01

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

by Nigel Turner, Xin Ying Lim, Hamish D. Toop, Brenna Osborne, Amanda E. Brandon, Elysha N. Taylor, Corrine E. Fiveash, Hemna Govindaraju, Jonathan D. Teo, Holly P. McEwen, Timothy A. Couttas, Stephen M. Butler, Abhirup Das, Greg M. Kowalski, Clinton R. Bruce, Kyle L. Hoehn, Thomas Fath, Carsten Schmitz-Peiffer, Gregory J. Cooney, Magdalene K. Montgomery, Jonathan C. Morris, Anthony S. Don
Published 2018-08-01

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

by Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Published 2018-02-01

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress

by Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. Santos, Kate GR. Quinlan, Nigel Turner, Daniel J. Fazakerley, Naresh Kumar, Kyle L. Hoehn
Published 2020-01-01