Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease

by Kulicke, Ruth, Cowley, Glenn S., Stein, Rachael, Root, David E., Heiman, Myriam, Shema Tirosh, Reut
Published 2015

Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks

by Wagner, Joel Patrick, Wolf-Yadlin, Alejandro, Sevecka, Mark, Grenier, Jennifer K., Root, David E., Lauffenburger, Douglas A., MacBeath, Gavin
Published 2014

A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression

by Oh, Hyung Suk, Bryant, Kevin F., Nieland, Thomas J., Mazumder, Aprotim, Bagul, Mukta, Bathe, Mark, Root, David E., Knipe, David M.
Published 2014

High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

by Logan, David J., Saulnier, Jessica, Lam, Daniel, Johnson, Caroline, Root, David E., Carpenter, Anne E., Sabatini, Bernardo L., Nieland, Thomas J
Published 2014

Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways

by Dang, Michelle, Armbruster, Nicole, Miller, Miles Aaron, Cermeno, Efrain A., Hartmann, Monika, Bell, George W., Root, David E., Herrlich, Andreas, Lauffenburger, Douglas A, Lodish, Harvey F
Published 2014

MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma

by Wood, Kris C., Konieczkowski, David J., Johannessen, Cory M., Boehm, Jesse S., Tamayo, Pablo, Botvinnik, Olga B., Mesirov, Jill P., Hahn, William C., Root, David E., Garraway, Levi A., Sabatini, David
Published 2014

A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection

by Shapira, Sagi D., Gat-Viks, Irit, Shum, Bennett O. V., Dricot, Amelie, DeGrace, Marciela M., Wu, Liguo, Gupta, Piyush, Hao, Tong, Silver, Serena J., Root, David E., Hill, David E., Regev, Aviv, Hacohen, Nir
Published 2012

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

by Shao, Diane D, Krall, Elsa B, Piccioni, Federica, Wang, Xiaoxing, Schinzel, Anna C, Rosenbluh, Joseph, Kim, Jong W, Zwang, Yaara, Roberts, Thomas M, Root, David E, Hahn, William C, Bhutkar, Arjun, Xue, Wen, Sood, Sabina, Jacks, Tyler E.
Published 2016

lincRNAs act in the circuitry controlling pluripotency and differentiation

by Guttman, Mitchell, Donaghey, Julie, Carey, Bryce W., Garber, Manuel, Grenier, Jennifer K., Munson, Glen, Young, Geneva, Lucas, Anne Bergstom, Ach, Robert, Bruhn, Laurakay, Yang, Xiaoping, Amit, Ido, Meissner, Alexander, Regev, Aviv, Rinn, John L., Root, David E., Lander, Eric Steven
Published 2012

Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells

by Scholl, Claudia, Frohling, Stefan, Dunn, Ian F., Schinzel, Anna C., Barbie, David A., Kim, So Young, Silver, Serena J., Tamayo, Pablo, Wadlow, Raymond C., Ramaswamy, Sridhar, Dohner, Konstanze, Bullinger, Lars, Sandy, Peter, Boehm, Jesse S., Root, David E., Hahn, William C., Gilliland, D. Gary, Jacks, Tyler E
Published 2015

Cancer Vulnerabilities Unveiled by Genomic Loss

by Nijhawan, Deepak, Zack, Travis I, Ren, Yin, Strickland, Matthew R, Lamothe, Rebecca, Schumacher, Steven E, Tsherniak, Aviad, Besche, Henrike C, Rosenbluh, Joseph, Shehata, Shyemaa, Cowley, Glenn S., Weir, Barbara A, Goldberg, Alfred L, Mesirov, Jill P., Root, David E, Beroukhim, Rameen, Hahn, William C., Bhatia, Sangeeta N
Published 2014

Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Target ID4

by Ren, Yin, von Maltzhan, Geoffrey, Agrawal, Amit, Mesirov, Jill P., Lo, Justin H., Cheung, Hiu Wing, Cowley, Glenn S., Weir, Barbara A., Boehm, Jesse S., Tamayo, Pablo, Karst, Alison M., Liu, Joyce F., Hirsch, Michelle S., Drapkin, Ronny, Root, David E., Fogal, Valentina, Ruoslahti, Erkki, Hahn, William C., Bhatia, Sangeeta N
Published 2014

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

by Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Hahn, William C., Kory, Nora, Sabatini, David, Pacold, Michael Edward
Published 2017

Synergistic interactions with PI3K inhibition that induce apoptosis

by Zwang, Yaara, Chen, Casandra, Rinne, Mikael L, Doench, John G, Piccioni, Federica, Tan, Li, Huang, Hai-Tsang, Wang, Jinhua, Ham, Young Jin, O'Connell, Joyce, Bhola, Patrick, Doshi, Mihir, Whitman, Matthew, Letai, Anthony, Root, David E, Gray, Nathanael, Hahn, William C, Jonas, Oliver H., Langer, Robert S, Cima, Michael J.
Published 2017

In vivo discovery of immunotherapy targets in the tumour microenvironment

by Zhou, Penghui, Shaffer, Donald R., Alvarez Arias, Diana A., Nakazaki, Yukoh, Pos, Wouter, Torres, Alexis J., Cremasco, Viviana, Dougan, Stephanie K., Cowley, Glenn S., Elpek, Kutlu, Brogdon, Jennifer, Lamb, John, Turley, Shannon J., Ploegh, Hidde, Root, David E., Dranoff, Glenn, Hacohen, Nir, Cantor, Harvey, Wucherpfennig, Kai W., Love, John C
Published 2014

Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits

by Chevrier, Nicolas, Mertins, Philipp, Artyomov, Maxim N., Shalek, Alex K., Iannacone, Matteo, Ciaccio, Mark F, Gat-Viks, Irit, Tonti, Elena, DeGrace, Marciela M., Clauser, Karl R., Garber, Manuel, Eisenhaure, Thomas, Yosef, Nir, Robinson, Jacob, Sutton, Amy, Andersen, Mette S., Root, David E, von Andrian, Ulrich, Jones, Richard Bradley, Park, Hongkun, Carr, Steven A., Regev, Aviv, Amit, Ido, Hacohen, Nir
Published 2014

Unbiased reconstruction of a mammalian transcriptional network mediating the differential response to pathogens

by Amit, Ido, Guttman, Mitchell, Leite, Ana Paula, Regev, Aviv, Garber, Manuel, Chevrier, Nicolas, Donner, Yoni, Eisenhaure, Thomas, Grenier, Jennifer K., Li, Weibo, Zuk, Or, Schubert, Lisa A., Birditt, Brian, Shay, Tal, Goren, Alon, Zhang, Xiaolan, Smith, Zachary, Deering, Raquel, McDonald, Rebecca C., Cabili, Moran N., Bernstein, Bradley E., Rinn, John L., Meissner, Alexander, Root, David E., Hacohen, Nir
Published 2014

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

by Floyd, Scott R., Pacold, Michael E., Huang, Qiuying, Clarke, Scott M., Rameseder, Jonathan, Lee, Michael J., Blake, Emily J., Fydrych, Anna, Ho, Richard, Del Rosario, Amanda M., Root, David E., Carpenter, Anne E., Hahn, William C., Sabatini, David M., Chen, Clark C., White, Forest M., Bradner, James E., Yaffe, Michael B., Lam, Fred Chiu-Lai, Cannell, Ian Gordon, Bryson, Bryan D., Greenberger, Benjamin Aaron, Chen, Grace, Maffa, Amanda D.
Published 2014

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer

by Possemato, Richard, Marks, Kevin M., Kim, Dohoon, Birsoy, Kivanc, Sethumadhavan, Shalini, Woo, Hin-Koon, Jang, Hyun G., Jha, Abhishek K., Chen, Walter W., Barrett, Francesca G., Stransky, Nicolas, Tsun, Zhi-Yang, Cowley, Glenn S., Barretina, Jordi, Kalaany, Nada Y., Hsu, Peggy P., Ottina, Kathleen, Chan, Albert M., Yuan, Bingbing B., Garraway, Levi A., Root, David E., Mino-Kenudson, Mari, Brachtel, Elena F., Driggers, Edward M., Shaul, Yoav, Pacold, Michael Edward, Sabatini, David
Published 2012