Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence

by Neha Shrestha, Elisa De Franco, Peter Arvan, Peter Arvan, Miriam Cnop, Miriam Cnop
Published 2021-04-01

Improved in vivo imaging method for individual islets across the mouse pancreas reveals a heterogeneous insulin secretion response to glucose

by Henriette Frikke-Schmidt, Peter Arvan, Randy J. Seeley, Corentin Cras-Méneur
Published 2021-01-01

Cell death–associated lipid droplet protein CIDE-A is a noncanonical marker of endoplasmic reticulum stress

by Yoshiaki Morishita, Aaron P. Kellogg, Dennis Larkin, Wei Chen, Suryakiran Vadrevu, Leslie Satin, Ming Liu, Peter Arvan
Published 2021-04-01

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

by Benedetta Gualeni, M. Helen Rajpar, Aaron Kellogg, Peter A. Bell, Peter Arvan, Raymond P. Boot-Handford, Michael D. Briggs
Published 2013-11-01

Correction: Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport

by Ming Liu, Leena Haataja, Jordan Wright, Nalinda P. Wickramasinghe, Qing-Xin Hua, Nelson F. Phillips, Fabrizio Barbetti, Michael A. Weiss, Peter Arvan
Published 2010-01-01

Sox17 regulates insulin secretion in the normal and pathologic mouse β cell.

by Diva Jonatan, Jason R Spence, Anna M Method, Matthew Kofron, Katie Sinagoga, Leena Haataja, Peter Arvan, Gail H Deutsch, James M Wells
Published 2014-01-01

Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport.

by Ming Liu, Leena Haataja, Jordan Wright, Nalinda P Wickramasinghe, Qing-Xin Hua, Nelson F Phillips, Fabrizio Barbetti, Michael A Weiss, Peter Arvan
Published 2010-10-01

Correction: Mutant -Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport.

by Ming Liu, Leena Haataja, Jordan Wright, Nalinda P. Wickramasinghe, Qing-Xin Hua, Nelson F. Phillips, Fabrizio Barbetti, Michael A. Weiss, Peter Arvan
Published 2010-01-01

Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure

by Emilyn U. Alejandro, Nadejda Bozadjieva, Doga Kumusoglu, Sarah Abdulhamid, Hannah Levine, Leena Haataja, Suryakiran Vadrevu, Leslie S. Satin, Peter Arvan, Ernesto Bernal-Mizrachi
Published 2015-12-01

PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

by Insook Jang, Anita Pottekat, Juthakorn Poothong, Jing Yong, Jacqueline Lagunas-Acosta, Adriana Charbono, Zhouji Chen, Donalyn L Scheuner, Ming Liu, Pamela Itkin-Ansari, Peter Arvan, Randal J Kaufman
Published 2019-06-01

Proinsulin misfolding is an early event in the progression to type 2 diabetes

by Anoop Arunagiri, Leena Haataja, Anita Pottekat, Fawnnie Pamenan, Soohyun Kim, Lori M Zeltser, Adrienne W Paton, James C Paton, Billy Tsai, Pamela Itkin-Ansari, Randal J Kaufman, Ming Liu, Peter Arvan
Published 2019-06-01

Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes

by Zhou Fang, Chen Weng, Haiyan Li, Ran Tao, Weihua Mai, Xiaoxiao Liu, Leina Lu, Sisi Lai, Qing Duan, Carlos Alvarez, Peter Arvan, Anthony Wynshaw-Boris, Yun Li, Yanxin Pei, Fulai Jin, Yan Li
Published 2019-03-01

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes

by Beibei Xu, Camille Allard, Ana I. Alvarez-Mercado, Taylor Fuselier, Jun Ho Kim, Laurel A. Coons, Sylvia C. Hewitt, Fumihiko Urano, Kenneth S. Korach, Ellis R. Levin, Peter Arvan, Z. Elizabeth Floyd, Franck Mauvais-Jarvis
Published 2018-07-01

Targeted induction of endoplasmic reticulum stress induces cartilage pathology.

by M Helen Rajpar, Ben McDermott, Louise Kung, Rachel Eardley, Lynette Knowles, Mel Heeran, David J Thornton, Richard Wilson, John F Bateman, Richard Poulsom, Peter Arvan, Karl E Kadler, Michael D Briggs, Raymond P Boot-Handford
Published 2009-10-01

Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size

by Lina Sui, Yurong Xin, Qian Du, Daniela Georgieva, Giacomo Diedenhofen, Leena Haataja, Qi Su, Michael V. Zuccaro, Jinrang Kim, Jiayu Fu, Yuan Xing, Yi He, Danielle Baum, Robin S. Goland, Yong Wang, Jose Oberholzer, Fabrizio Barbetti, Peter Arvan, Sandra Kleiner, Dieter Egli
Published 2021-03-01

Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

by Xing-Huang Gao, Dawid Krokowski, Bo-Jhih Guan, Ilya Bederman, Mithu Majumder, Marc Parisien, Luda Diatchenko, Omer Kabil, Belinda Willard, Ruma Banerjee, Benlian Wang, Gurkan Bebek, Charles R. Evans, Paul L. Fox, Stanton L. Gerson, Charles L. Hoppel, Ming Liu, Peter Arvan, Maria Hatzoglou
Published 2015-11-01

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

by Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien Alpy, Alice P.S. Kong, Peter I. Benke, Federico Torta, Adrian Kee Keong Teo, Isabelle Leclerc, Michele Solimena, Dale B. Wigley, Guy A. Rutter
Published 2020-10-01

GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer

by Wei Zhou, Ben Brumpton, Omer Kabil, Julius Gudmundsson, Gudmar Thorleifsson, Josh Weinstock, Matthew Zawistowski, Jonas B. Nielsen, Layal Chaker, Marco Medici, Alexander Teumer, Silvia Naitza, Serena Sanna, Ulla T. Schultheiss, Anne Cappola, Juha Karjalainen, Mitja Kurki, Morgan Oneka, Peter Taylor, Lars G. Fritsche, Sarah E. Graham, Brooke N. Wolford, William Overton, Humaira Rasheed, Eirin B. Haug, Maiken E. Gabrielsen, Anne Heidi Skogholt, Ida Surakka, George Davey Smith, Anita Pandit, Tanmoy Roychowdhury, Whitney E. Hornsby, Jon G. Jonasson, Leigha Senter, Sandya Liyanarachchi, Matthew D. Ringel, Li Xu, Lambertus A. Kiemeney, Huiling He, Romana T. Netea-Maier, Jose I. Mayordomo, Theo S. Plantinga, Jon Hrafnkelsson, Hannes Hjartarson, Erich M. Sturgis, Aarno Palotie, Mark Daly, Cintia E. Citterio, Peter Arvan, Chad M. Brummett, Michael Boehnke, Albert de la Chapelle, Kari Stefansson, Kristian Hveem, Cristen J. Willer, Bjørn Olav Åsvold
Published 2020-08-01