Skeletal Dysplasias Associated with Mild Myopathy—A Clinical and Molecular Review

by Katarzyna A. Piróg, Michael D. Briggs
Published 2010-01-01

Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases.

by Katarzyna A Piróg, Yoshihisa Katakura, Aleksandr Mironov, Michael D Briggs
Published 2013-01-01

Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growth plate and decrease bone growth.

by Louise H W Kung, M Helen Rajpar, Richard Preziosi, Michael D Briggs, Raymond P Boot-Handford
Published 2015-01-01

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

by Benedetta Gualeni, M. Helen Rajpar, Aaron Kellogg, Peter A. Bell, Peter Arvan, Raymond P. Boot-Handford, Michael D. Briggs
Published 2013-11-01

Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia.

by Katarzyna A Piróg, Andreja Irman, Siobhan Young, Poonam Halai, Peter A Bell, Raymond P Boot-Handford, Michael D Briggs
Published 2014-01-01

Collagen XXVII organises the pericellular matrix in the growth plate.

by Darren A Plumb, Laila Ferrara, Tanja Torbica, Lynnette Knowles, Aleksandr Mironov, Karl E Kadler, Michael D Briggs, Raymond P Boot-Handford
Published 2011-01-01

Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis

by Louise H. W. Kung, Lorna Mullan, Jamie Soul, Ping Wang, Kazutoshi Mori, John F. Bateman, Michael D. Briggs, Raymond P. Boot-Handford
Published 2019-09-01

Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures

by Peter A. Bell, Raimund Wagener, Frank Zaucke, Manuel Koch, Julian Selley, Stacey Warwood, David Knight, Raymond P. Boot-Handford, David J. Thornton, Michael D. Briggs
Published 2013-06-01

XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease.

by Katarzyna A Piróg, Ella P Dennis, Claire L Hartley, Robert M Jackson, Jamie Soul, Jean-Marc Schwartz, John F Bateman, Raymond P Boot-Handford, Michael D Briggs
Published 2019-07-01

Targeted induction of endoplasmic reticulum stress induces cartilage pathology.

by M Helen Rajpar, Ben McDermott, Louise Kung, Rachel Eardley, Lynette Knowles, Mel Heeran, David J Thornton, Richard Wilson, John F Bateman, Richard Poulsom, Peter Arvan, Karl E Kadler, Michael D Briggs, Raymond P Boot-Handford
Published 2009-10-01

Increased hippocampal excitability in miR-324-null mice

by Dan J. Hayman, Tamara Modebadze, Sarah Charlton, Kat Cheung, Jamie Soul, Hua Lin, Yao Hao, Colin G. Miles, Dimitra Tsompani, Robert M. Jackson, Michael D. Briggs, Katarzyna A. Piróg, Ian M. Clark, Matt J. Barter, Gavin J. Clowry, Fiona E. N. LeBeau, David A. Young
Published 2021-05-01