Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties.

by Javier Guenaga, Natalia de Val, Karen Tran, Yu Feng, Karen Satchwell, Andrew B Ward, Richard T Wyatt
Published 2015-01-01

Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design

by Shailendra Kumar Sharma, Natalia de Val, Shridhar Bale, Javier Guenaga, Karen Tran, Yu Feng, Viktoriya Dubrovskaya, Andrew B. Ward, Richard T. Wyatt
Published 2015-04-01

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response.

by Viktoriya Dubrovskaya, Javier Guenaga, Natalia de Val, Richard Wilson, Yu Feng, Arlette Movsesyan, Gunilla B Karlsson Hedestam, Andrew B Ward, Richard T Wyatt
Published 2017-09-01

Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer

by Linling He, Xiaohe Lin, Natalia de Val, Natalia de Val, Natalia de Val, Karen L. Saye-Francisco, Karen L. Saye-Francisco, Colin J. Mann, Ryan Augst, Charles D. Morris, Parisa Azadnia, Bin Zhou, Devin Sok, Devin Sok, Devin Sok, Gabriel Ozorowski, Gabriel Ozorowski, Gabriel Ozorowski, Andrew B. Ward, Andrew B. Ward, Andrew B. Ward, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Jiang Zhu, Jiang Zhu, Jiang Zhu
Published 2017-08-01

Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo

by Matthew J. Brooks, Holly Y. Chen, Ryan A. Kelley, Anupam K. Mondal, Kunio Nagashima, Natalia De Val, Tiansen Li, Vijender Chaitankar, Anand Swaroop
Published 2019-11-01

Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies.

by Yu Feng, Karen Tran, Shridhar Bale, Shailendra Kumar, Javier Guenaga, Richard Wilson, Natalia de Val, Heather Arendt, Joanne DeStefano, Andrew B Ward, Richard T Wyatt
Published 2016-08-01

Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery

by Istvan Botos, George T. Lountos, Weimin Wu, Scott Cherry, Rodolfo Ghirlando, Arsen M. Kudzhaev, Tatyana V. Rotanova, Natalia de Val, Joseph E. Tropea, Alla Gustchina, Alexander Wlodawer
Published 2019-11-01

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies

by Shridhar Bale, Alexandra Martiné, Richard Wilson, Anna-Janina Behrens, Valérie Le Fourn, Natalia de Val, Natalia de Val, Shailendra K. Sharma, Karen Tran, Jonathan L. Torres, Jonathan L. Torres, Jonathan L. Torres, Pierre-Alain Girod, Andrew B. Ward, Andrew B. Ward, Andrew B. Ward, Max Crispin, Max Crispin, Max Crispin, Richard T. Wyatt, Richard T. Wyatt, Richard T. Wyatt
Published 2018-05-01

Zika Virus-Induced Neuronal Apoptosis via Increased Mitochondrial Fragmentation

by Shu Yang, Kirill Gorshkov, Emily M. Lee, Miao Xu, Yu-Shan Cheng, Nuo Sun, Ferri Soheilian, Natalia de Val, Guoli Ming, Hongjun Song, Hengli Tang, Wei Zheng
Published 2020-12-01

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

by Leopold Kong, Linling He, Natalia de Val, Nemil Vora, Charles D. Morris, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Andrew B. Ward, Ian A. Wilson, Jiang Zhu
Published 2016-06-01

Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E.

by Michael H Matho, Natalia de Val, Gregory M Miller, Joshua Brown, Andrew Schlossman, Xiangzhi Meng, Shane Crotty, Bjoern Peters, Yan Xiang, Linda C Hsieh-Wilson, Andrew B Ward, Dirk M Zajonc
Published 2014-12-01

Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage

by Lifei Yang, Shailendra Kumar Sharma, Christopher Cottrell, Javier Guenaga, Karen Tran, Richard Wilson, Anna-Janina Behrens, Max Crispin, Max Crispin, Max Crispin, Natalia de Val, Richard T. Wyatt, Richard T. Wyatt, Richard T. Wyatt
Published 2018-07-01

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

by Linling He, Natalia de Val, Charles D. Morris, Nemil Vora, Therese C. Thinnes, Leopold Kong, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Ian A Wilson, David Nemazee, Andrew B. Ward, Jiang Zhu
Published 2016-06-01

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

by Anita Sarkar, Shridhar Bale, Anna-Janina Behrens, Sonu Kumar, Shailendra Kumar Sharma, Natalia de Val, Jesper Pallesen, Adriana Irimia, Devan C. Diwanji, Robyn L. Stanfield, Andrew B. Ward, Max Crispin, Richard T. Wyatt, Ian A. Wilson
Published 2018-05-01

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

by Yoann Aldon, Paul F. McKay, Joel Allen, Gabriel Ozorowski, Réka Felfödiné Lévai, Monica Tolazzi, Paul Rogers, Linling He, Natalia de Val, Katalin Fábián, Gabriella Scarlatti, Jiang Zhu, Andrew B. Ward, Max Crispin, Robin J. Shattock
Published 2018-09-01

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model

by James E. Voss, Raiees Andrabi, Laura E. McCoy, Natalia de Val, Roberta P. Fuller, Terrence Messmer, Ching-Yao Su, Devin Sok, Salar N. Khan, Fernando Garces, Laura K. Pritchard, Richard T. Wyatt, Andrew B. Ward, Max Crispin, Ian A. Wilson, Dennis R. Burton
Published 2018-01-01

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model

by James E. Voss, Raiees Andrabi, Laura E. McCoy, Natalia de Val, Roberta P. Fuller, Terrence Messmer, Ching-Yao Su, Devin Sok, Salar N. Khan, Fernando Garces, Laura K. Pritchard, Richard T. Wyatt, Andrew B. Ward, Max Crispin, Ian A. Wilson, Dennis R. Burton
Published 2017-10-01

IDH1 mutations induce organelle defects via dysregulated phospholipids

by Adrian Lita, Artem Pliss, Andrey Kuzmin, Tomohiro Yamasaki, Lumin Zhang, Tyrone Dowdy, Christina Burks, Natalia de Val, Orieta Celiku, Victor Ruiz-Rodado, Elena-Raluca Nicoli, Michael Kruhlak, Thorkell Andresson, Sudipto Das, Chunzhang Yang, Rebecca Schmitt, Christel Herold-Mende, Mark R. Gilbert, Paras N. Prasad, Mioara Larion
Published 2021-01-01

Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.

by Torben Schiffner, Jesper Pallesen, Rebecca A Russell, Jonathan Dodd, Natalia de Val, Celia C LaBranche, David Montefiori, Georgia D Tomaras, Xiaoying Shen, Scarlett L Harris, Amin E Moghaddam, Oleksandr Kalyuzhniy, Rogier W Sanders, Laura E McCoy, John P Moore, Andrew B Ward, Quentin J Sattentau
Published 2018-05-01

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice

by Nan Li, Madeline B. Torres, Madeline R. Spetz, Ruixue Wang, Luyi Peng, Meijie Tian, Christopher M. Dower, Rosa Nguyen, Ming Sun, Chin-Hsien Tai, Natalia de Val, Raul Cachau, Xiaolin Wu, Stephen M. Hewitt, Rosandra N. Kaplan, Javed Khan, Brad St Croix, Carol J. Thiele, Mitchell Ho
Published 2021-06-01