Sphingolipid Pathway as a Source of Vulnerability in IDH1<i>^mut</i> Glioma

by Tyrone Dowdy, Lumin Zhang, Orieta Celiku, Sriya Movva, Adrian Lita, Victor Ruiz-Rodado, Mark R. Gilbert, Mioara Larion
Published 2020-10-01

Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis.

by Amrita K Cheema, Irene Maier, Tyrone Dowdy, Yiwen Wang, Rajbir Singh, Paul M Ruegger, James Borneman, Albert J Fornace, Robert H Schiestl
Published 2016-01-01

Metabolic Landscape of a Genetically Engineered Mouse Model of IDH1 Mutant Glioma

by Victor Ruiz-Rodado, Tomohiro Seki, Tyrone Dowdy, Adrian Lita, Meili Zhang, Sue Han, Chunzhang Yang, Murali K. Cherukuri, Mark R. Gilbert, Mioara Larion
Published 2020-06-01

Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).

by Amanda Haymond, Chinchu Johny, Tyrone Dowdy, Brandon Schweibenz, Karen Villarroel, Richard Young, Clark J Mantooth, Trishal Patel, Jessica Bases, Geraldine San Jose, Emily R Jackson, Cynthia S Dowd, Robin D Couch
Published 2014-01-01

Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies

by Nivedita M. Ratnam, Heather M. Sonnemann, Stephen C. Frederico, Huanwen Chen, Marsha-Kay N. D. Hutchinson, Tyrone Dowdy, Caitlin M. Reid, Jinkyu Jung, Wei Zhang, Hua Song, Meili Zhang, Dionne Davis, Mioara Larion, Amber J. Giles, Mark R. Gilbert
Published 2021-07-01

IDH1 mutations induce organelle defects via dysregulated phospholipids

by Adrian Lita, Artem Pliss, Andrey Kuzmin, Tomohiro Yamasaki, Lumin Zhang, Tyrone Dowdy, Christina Burks, Natalia de Val, Orieta Celiku, Victor Ruiz-Rodado, Elena-Raluca Nicoli, Michael Kruhlak, Thorkell Andresson, Sudipto Das, Chunzhang Yang, Rebecca Schmitt, Christel Herold-Mende, Mark R. Gilbert, Paras N. Prasad, Mioara Larion
Published 2021-01-01

Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

by Victor Ruiz-Rodado, Adrian Lita, Tyrone Dowdy, Orieta Celiku, Alejandra Cavazos Saldana, Herui Wang, Chun Zhang Yang, Raj Chari, Aiguo Li, Wei Zhang, Hua Song, Meili Zhang, Susie Ahn, Dionne Davis, Xiang Chen, Zhengping Zhuang, Christel Herold-Mende, Kylie J. Walters, Mark R. Gilbert, Mioara Larion
Published 2020-10-01