Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines

by Linling He, Anshul Chaudhary, Xiaohe Lin, Cindy Sou, Tanwee Alkutkar, Sonu Kumar, Timothy Ngo, Ezra Kosviner, Gabriel Ozorowski, Robyn L. Stanfield, Andrew B. Ward, Ian A. Wilson, Jiang Zhu
Published 2021-05-01

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers

by Kathrin Koch, Sarah Kalusche, Jonathan L. Torres, Robyn L. Stanfield, Welbeck Danquah, Kamal Khazanehdari, Hagen von Briesen, Eric R. Geertsma, Ian A. Wilson, Ulrich Wernery, Friedrich Koch-Nolte, Andrew B. Ward, Ursula Dietrich
Published 2017-08-01

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

by Anita Sarkar, Shridhar Bale, Anna-Janina Behrens, Sonu Kumar, Shailendra Kumar Sharma, Natalia de Val, Jesper Pallesen, Adriana Irimia, Devan C. Diwanji, Robyn L. Stanfield, Andrew B. Ward, Max Crispin, Richard T. Wyatt, Ian A. Wilson
Published 2018-05-01

Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.

by Adriana Irimia, Andreia M Serra, Anita Sarkar, Ronald Jacak, Oleksandr Kalyuzhniy, Devin Sok, Karen L Saye-Francisco, Torben Schiffner, Ryan Tingle, Michael Kubitz, Yumiko Adachi, Robyn L Stanfield, Marc C Deller, Dennis R Burton, William R Schief, Ian A Wilson
Published 2017-02-01

Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.

by Jean-Philippe Julien, Devin Sok, Reza Khayat, Jeong Hyun Lee, Katie J Doores, Laura M Walker, Alejandra Ramos, Devan C Diwanji, Robert Pejchal, Albert Cupo, Umesh Katpally, Rafael S Depetris, Robyn L Stanfield, Ryan McBride, Andre J Marozsan, James C Paulson, Rogier W Sanders, John P Moore, Dennis R Burton, Pascal Poignard, Andrew B Ward, Ian A Wilson
Published 2013-01-01

Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.

by Joseph G Jardine, Devin Sok, Jean-Philippe Julien, Bryan Briney, Anita Sarkar, Chi-Hui Liang, Erin M Scherer, Carole J Henry Dunand, Yumiko Adachi, Devan Diwanji, Jessica Hsueh, Meaghan Jones, Oleksandr Kalyuzhniy, Michael Kubitz, Skye Spencer, Matthias Pauthner, Karen L Saye-Francisco, Fabian Sesterhenn, Patrick C Wilson, Denise A Galloway, Robyn L Stanfield, Ian A Wilson, Dennis R Burton, William R Schief
Published 2016-09-01

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.

by Joseph G Jardine, Devin Sok, Jean-Philippe Julien, Bryan Briney, Anita Sarkar, Chi-Hui Liang, Erin A Scherer, Carole J Henry Dunand, Yumiko Adachi, Devan Diwanji, Jessica Hsueh, Meaghan Jones, Oleksandr Kalyuzhniy, Michael Kubitz, Skye Spencer, Matthias Pauthner, Karen L Saye-Francisco, Fabian Sesterhenn, Patrick C Wilson, Denise M Galloway, Robyn L Stanfield, Ian A Wilson, Dennis R Burton, William R Schief
Published 2016-08-01