Mendelian randomisation and causal inference in observational epidemiology.

by Nuala A Sheehan, Vanessa Didelez, Paul R Burton, Martin D Tobin
Published 2008-08-01

Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls.

by María Soler Artigas, Louise V Wain, Nick Shrine, Tricia M McKeever, UK BiLEVE, Ian Sayers, Ian P Hall, Martin D Tobin
Published 2017-01-01

Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function [version 2; referees: 2 approved]

by Adeolu B. Adewoye, Nick Shrine, Linda Odenthal-Hesse, Samantha Welsh, Anders Malarstig, Scott Jelinsky, Iain Kilty, Martin D. Tobin, Edward J. Hollox, Louise V. Wain
Published 2018-04-01

Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function [version 1; referees: 2 approved]

by Adeolu B. Adewoye, Nick Shrine, Linda Odenthal-Hesse, Samantha Welsh, Anders Malarstig, Scott Jelinsky, Iain Kilty, Martin D. Tobin, Edward J. Hollox, Louise V. Wain
Published 2018-02-01

The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci.

by Louise V Wain, Inti Pedroso, John E Landers, Gerome Breen, Christopher E Shaw, P Nigel Leigh, Robert H Brown, Martin D Tobin, Ammar Al-Chalabi
Published 2009-12-01

Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies

by Matthew Moll, Sharon M. Lutz, Auyon J. Ghosh, Phuwanat Sakornsakolpat, Craig P. Hersh, Terri H. Beaty, Frank Dudbridge, Martin D. Tobin, Murray A. Mittleman, Edwin K. Silverman, Brian D. Hobbs, Michael H. Cho
Published 2020-05-01

Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study

by Maria C. Magnus, Anna L. Guyatt, Rebecca B. Lawn, Annah B. Wyss, Katerina Trajanoska, Leanne K. Küpers, Fernando Rivadeneira, Martin D. Tobin, Stephanie J. London, Debbie A. Lawlor, Louise A. C. Millard, Abigail Fraser
Published 2020-03-01

Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank

by Katherine A. Fawcett, Kijoung Song, Guoqing Qian, Aliki-Eleni Farmaki, Richard Packer, Catherine John, Nick Shrine, Raquel Granell, Sue Ring, Nicholas J. Timpson, Laura M. Yerges-Armstrong, Richard Eastell, Louise V. Wain, Robert A. Scott, Martin D. Tobin, Ian P. Hall
Published 2021-05-01

Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma.

by Louise V Wain, Linda Odenthal-Hesse, Razan Abujaber, Ian Sayers, Caroline Beardsmore, Erol A Gaillard, Sally Chappell, Cristian M Dogaru, Tricia McKeever, Tamar Guetta-Baranes, Noor Kalsheker, Claudia E Kuehni, Ian P Hall, Martin D Tobin, Edward J Hollox
Published 2014-01-01

Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease.

by Maria Sabater-Lleal, Anders Mälarstig, Lasse Folkersen, María Soler Artigas, Damiano Baldassarre, Maryam Kavousi, Peter Almgren, Fabrizio Veglia, Guy Brusselle, Albert Hofman, Gunnar Engström, Oscar H Franco, Olle Melander, Gabrielle Paulsson-Berne, Hugh Watkins, Per Eriksson, Steve E Humphries, Elena Tremoli, Ulf de Faire, Martin D Tobin, Anders Hamsten
Published 2014-01-01

GSTCD and INTS12 regulation and expression in the human lung.

by Ma'en Obeidat, Suzanne Miller, Kelly Probert, Charlotte K Billington, Amanda P Henry, Emily Hodge, Carl P Nelson, Ceri E Stewart, Caroline Swan, Louise V Wain, María Soler Artigas, Erik Melén, Kevin Ushey, Ke Hao, Maxime Lamontagne, Yohan Bossé, Dirkje S Postma, Martin D Tobin, Ian Sayers, Ian P Hall
Published 2013-01-01

Large-scale candidate gene analysis of HDL particle features.

by Bernhard M Kaess, Maciej Tomaszewski, Peter S Braund, Klaus Stark, Suzanne Rafelt, Marcus Fischer, Robert Hardwick, Christopher P Nelson, Radoslaw Debiec, Fritz Huber, Werner Kremer, Hans Robert Kalbitzer, Lynda M Rose, Daniel I Chasman, Jemma Hopewell, Robert Clarke, Paul R Burton, Martin D Tobin, Christian Hengstenberg, Nilesh J Samani
Published 2011-01-01

The sputum microbiome is distinct between COPD and health, independent of smoking history

by Koirobi Haldar, Leena George, Zhang Wang, Vijay Mistry, Mohammadali Yavari Ramsheh, Robert C. Free, Catherine John, Nicola F. Reeve, Bruce E. Miller, Ruth Tal-Singer, Adam J. Webb, Anthony J. Brookes, Martin D. Tobin, Dave Singh, Gavin C. Donaldson, Jadwiga A. Wedzicha, James R. Brown, Michael R. Barer, Christopher E. Brightling
Published 2020-07-01

Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.

by Louise V Wain, Ian Sayers, María Soler Artigas, Michael A Portelli, Eleftheria Zeggini, Ma'en Obeidat, Don D Sin, Yohan Bossé, David Nickle, Corry-Anke Brandsma, Anders Malarstig, Ciara Vangjeli, Scott A Jelinsky, Sally John, Iain Kilty, Tricia McKeever, Nick R G Shrine, James P Cook, Shrina Patel, Tim D Spector, Edward J Hollox, Ian P Hall, Martin D Tobin
Published 2014-05-01

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

by Laura J. Corbin, Vanessa Y. Tan, David A. Hughes, Kaitlin H. Wade, Dirk S. Paul, Katherine E. Tansey, Frances Butcher, Frank Dudbridge, Joanna M. Howson, Momodou W. Jallow, Catherine John, Nathalie Kingston, Cecilia M. Lindgren, Michael O’Donavan, Stephen O’Rahilly, Michael J. Owen, Colin N. A. Palmer, Ewan R. Pearson, Robert A. Scott, David A. van Heel, John Whittaker, Tim Frayling, Martin D. Tobin, Louise V. Wain, George Davey Smith, David M. Evans, Fredrik Karpe, Mark I. McCarthy, John Danesh, Paul W. Franks, Nicholas J. Timpson
Published 2018-02-01

Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels.

by Gian Andri Thun, Medea Imboden, Ilaria Ferrarotti, Ashish Kumar, Ma'en Obeidat, Michele Zorzetto, Margot Haun, Ivan Curjuric, Alexessander Couto Alves, Victoria E Jackson, Eva Albrecht, Janina S Ried, Alexander Teumer, Lorna M Lopez, Jennifer E Huffman, Stefan Enroth, Yohan Bossé, Ke Hao, Wim Timens, Ulf Gyllensten, Ozren Polasek, James F Wilson, Igor Rudan, Caroline Hayward, Andrew J Sandford, Ian J Deary, Beate Koch, Eva Reischl, Holger Schulz, Jennie Hui, Alan L James, Thierry Rochat, Erich W Russi, Marjo-Riitta Jarvelin, David P Strachan, Ian P Hall, Martin D Tobin, Morten Dahl, Sune Fallgaard Nielsen, Børge G Nordestgaard, Florian Kronenberg, Maurizio Luisetti, Nicole M Probst-Hensch
Published 2013-01-01

A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample.

by Ma'en Obeidat, Louise V Wain, Nick Shrine, Noor Kalsheker, Maria Soler Artigas, Emmanouela Repapi, Paul R Burton, Toby Johnson, Adaikalavan Ramasamy, Jing Hua Zhao, Guangju Zhai, Jennifer E Huffman, Veronique Vitart, Eva Albrecht, Wilmar Igl, Anna-Liisa Hartikainen, Anneli Pouta, Gemma Cadby, Jennie Hui, Lyle J Palmer, David Hadley, Wendy L McArdle, Alicja R Rudnicka, Inês Barroso, Ruth J F Loos, Nicholas J Wareham, Massimo Mangino, Nicole Soranzo, Tim D Spector, Sven Gläser, Georg Homuth, Henry Völzke, Panos Deloukas, Raquel Granell, John Henderson, Ivica Grkovic, Stipan Jankovic, Lina Zgaga, Ozren Polašek, Igor Rudan, Alan F Wright, Harry Campbell, Sarah H Wild, James F Wilson, Joachim Heinrich, Medea Imboden, Nicole M Probst-Hensch, Ulf Gyllensten, Åsa Johansson, Ghazal Zaboli, Linda Mustelin, Taina Rantanen, Ida Surakka, Jaakko Kaprio, Marjo-Riitta Jarvelin, Caroline Hayward, David M Evans, Beate Koch, Arthur William Musk, Paul Elliott, David P Strachan, Martin D Tobin, Ian Sayers, Ian P Hall, SpiroMeta Consortium
Published 2011-01-01

Variants associated with HHIP expression have sex-differential effects on lung function [version 2; peer review: 2 approved]

by Katherine A. Fawcett, Ma'en Obeidat, Carl Melbourne, Nick Shrine, Anna L. Guyatt, Catherine John, Jian'an Luan, Anne Richmond, Marta R. Moksnes, Raquel Granell, Stefan Weiss, Medea Imboden, Sebastian May-Wilson, Pirro Hysi, Thibaud S. Boutin, Laura Portas, Claudia Flexeder, Sarah E. Harris, Carol A. Wang, Leo-Pekka Lyytikäinen, Teemu Palviainen, Rachel E. Foong, Dirk Keidel, Cosetta Minelli, Claudia Langenberg, Yohan Bossé, Maarten Van den Berge, Don D. Sin, Ke Hao, Archie Campbell, David Porteous, Sandosh Padmanabhan, Blair H. Smith, David M. Evans, Sue Ring, Arnulf Langhammer, Kristian Hveem, Cristen Willer, Ralf Ewert, Beate Stubbe, Nicola Pirastu, Lucija Klaric, Peter K. Joshi, Karina Patasova, Mangino Massimo, Ozren Polasek, John M. Starr, Stefan Karrasch, Konstantin Strauch, Thomas Meitinger, Igor Rudan, Taina Rantanen, Kirsi Pietiläinen, Mika Kähönen, Olli T. Raitakari, Graham L. Hall, Peter D. Sly, Craig E. Pennell, Jaakko Kaprio, Terho Lehtimäki, Veronique Vitart, Ian J. Deary, Debbie Jarvis, James F. Wilson, Tim Spector, Nicole Probst-Hensch, Nicholas J. Wareham, Henry Völzke, John Henderson, David P. Strachan, Ben M. Brumpton, Caroline Hayward, Ian P. Hall, Martin D. Tobin, Louise V. Wain
Published 2021-05-01

Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved]

by Katherine A. Fawcett, Ma'en Obeidat, Carl Melbourne, Nick Shrine, Anna L. Guyatt, Catherine John, Jian'an Luan, Anne Richmond, Marta R. Moksnes, Raquel Granell, Stefan Weiss, Medea Imboden, Sebastian May-Wilson, Pirro Hysi, Thibaud S. Boutin, Laura Portas, Claudia Flexeder, Sarah E. Harris, Carol A. Wang, Leo-Pekka Lyytikäinen, Teemu Palviainen, Rachel E. Foong, Dirk Keidel, Cosetta Minelli, Claudia Langenberg, Yohan Bossé, Maarten Van den Berge, Don D. Sin, Ke Hao, Archie Campbell, David Porteous, Sandosh Padmanabhan, Blair H. Smith, David M. Evans, Sue Ring, Arnulf Langhammer, Kristian Hveem, Cristen Willer, Ralf Ewert, Beate Stubbe, Nicola Pirastu, Lucija Klaric, Peter K. Joshi, Karina Patasova, Mangino Massimo, Ozren Polasek, John M. Starr, Stefan Karrasch, Konstantin Strauch, Thomas Meitinger, Igor Rudan, Taina Rantanen, Kirsi Pietiläinen, Mika Kähönen, Olli T. Raitakari, Graham L. Hall, Peter D. Sly, Craig E. Pennell, Jaakko Kaprio, Terho Lehtimäki, Veronique Vitart, Ian J. Deary, Debbie Jarvis, James F. Wilson, Tim Spector, Nicole Probst-Hensch, Nicholas J. Wareham, Henry Völzke, John Henderson, David P. Strachan, Ben M. Brumpton, Caroline Hayward, Ian P. Hall, Martin D. Tobin, Louise V. Wain
Published 2020-06-01

Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants

by Xutong Zhao, Dandi Qiao, Chaojie Yang, Silva Kasela, Wonji Kim, Yanlin Ma, Nick Shrine, Chiara Batini, Tamar Sofer, Sarah A. Gagliano Taliun, Phuwanat Sakornsakolpat, Pallavi P. Balte, Dmitry Prokopenko, Bing Yu, Leslie A. Lange, Josée Dupuis, Brian E. Cade, Jiwon Lee, Sina A. Gharib, Michelle Daya, Cecelia A. Laurie, Ingo Ruczinski, L. Adrienne Cupples, Laura R. Loehr, Traci M. Bartz, Alanna C. Morrison, Bruce M. Psaty, Ramachandran S. Vasan, James G. Wilson, Kent D. Taylor, Peter Durda, W. Craig Johnson, Elaine Cornell, Xiuqing Guo, Yongmei Liu, Russell P. Tracy, Kristin G. Ardlie, François Aguet, David J. VanDenBerg, George J. Papanicolaou, Jerome I. Rotter, Kathleen C. Barnes, Deepti Jain, Deborah A. Nickerson, Donna M. Muzny, Ginger A. Metcalf, Harshavardhan Doddapaneni, Shannon Dugan-Perez, Namrata Gupta, Stacey Gabriel, Stephen S. Rich, George T. O’Connor, Susan Redline, Robert M. Reed, Cathy C. Laurie, Martha L. Daviglus, Liana K. Preudhomme, Kristin M. Burkart, Robert C. Kaplan, Louise V. Wain, Martin D. Tobin, Stephanie J. London, Tuuli Lappalainen, Elizabeth C. Oelsner, Goncalo R. Abecasis, Edwin K. Silverman, R. Graham Barr, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lung Working Group, Michael H. Cho, Ani Manichaikul
Published 2020-10-01