Pharmacogenetics of Oral Antidiabetic Drugs

by Matthijs L. Becker, Ewan R. Pearson, Ivan Tkáč
Published 2013-01-01

Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?

by Angus G Jones, Mike Lonergan, William E Henley, Ewan R Pearson, Andrew T Hattersley, Beverley M Shields
Published 2016-01-01

Reducing Glut2 throughout the body does not result in cognitive behaviour differences in aged male mice

by Nicola Morrice, Lidy van Aalten, Alison McNeilly, Rory J. McCrimmon, Ewan R. Pearson, Rosamund Langston, Calum Sutherland
Published 2020-09-01

Effects of TCF7L2 rs7903146 variant on metformin response in patients with type 2 diabetes

by Tanja Dujic, Tamer Bego, Maja Malenica, Zelija Velija-Asimi, Emma Ahlqvist, Leif Groop, Ewan R. Pearson, Adlija Causevic, Sabina Semiz
Published 2019-05-01

Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype

by Tanja Dujic, Sandra Cvijic, Amar Elezovic, Tamer Bego, Selma Imamovic Kadric, Maja Malenica, Alisa Elezovic, Ewan R. Pearson, Aida Kulo
Published 2021-05-01

What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study

by Andrew P. McGovern, John M. Dennis, Beverley M. Shields, Andrew T. Hattersley, Ewan R. Pearson, Angus G. Jones, On behalf of the MASTERMIND Consortium
Published 2019-04-01

Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.

by Ewan R Pearson, Sylvia F Boj, Anna M Steele, Timothy Barrett, Karen Stals, Julian P Shield, Sian Ellard, Jorge Ferrer, Andrew T Hattersley
Published 2007-04-01

The impact of phenotype, ethnicity and genotype on progression of type 2 diabetes mellitus

by Anand Thakarakkattil Narayanan Nair, Louise A. Donnelly, Adem Y. Dawed, Sushrima Gan, Ranjit M. Anjana, Mohan Viswanathan, Colin N. A. Palmer, Ewan R. Pearson
Published 2020-04-01

Polymorphism in INSR Locus Modifies Risk of Atrial Fibrillation in Patients on Thyroid Hormone Replacement Therapy

by Enrique Soto-Pedre, Moneeza K. Siddiqui, Cyrielle Maroteau, Adem Y. Dawed, Alex S. Doney, Colin N. A. Palmer, Ewan R. Pearson, Graham P. Leese, Graham P. Leese
Published 2021-06-01

The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection.

by Changwei Chen, Jennifer R Gallagher, Jamie Tarlton, Lidy van Aalten, Susan E Bray, Michael L J Ashford, Rory J McCrimmon, Ewan R Pearson, Alison D McNeilly, Calum Sutherland
Published 2021-01-01

Cohort profile: DOLORisk Dundee: a longitudinal study of chronic neuropathic pain

by Claire Jones, Blair H. Smith, Geert Crombez, Harry L. Hébert, Abirami Veluchamy, Georgios Baskozos, Francesca Fardo, Dimitri M. L. Van Ryckeghem, Mathilde M. V. Pascal, Keith Milburn, Ewan R. Pearson, David L. H. Bennett, Weihua Meng, Colin N. A. Palmer
Published 2021-06-01

Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT-DETECT prediction model - a DIRECT study.

by Simone P Rauh, Martijn W Heymans, Anitra D M Koopman, Giel Nijpels, Coen D Stehouwer, Barbara Thorand, Wolfgang Rathmann, Christa Meisinger, Annette Peters, Tonia de Las Heras Gala, Charlotte Glümer, Oluf Pedersen, Henna Cederberg, Johanna Kuusisto, Markku Laakso, Ewan R Pearson, Paul W Franks, Femke Rutters, Jacqueline M Dekker
Published 2017-01-01

Risk factors for genital infections in people initiating SGLT2 inhibitors and their impact on discontinuation

by Rury R Holman, Mark Walker, Beverley M Shields, Andrew T Hattersley, Andrew P McGovern, Michael Hogg, Naveed A Sattar, Ewan R Pearson, Angus G Jones, William E Henley, Mike Lonergan, Lauren R Rodgers, Willie T Hamilton, Catherine Angwin, Kennedy J Cruickshank, Stephen C L Gough, Alastair M Gray, Christopher Hyde, Christopher Jennison
Published 2020-04-01

Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.

by Colin N A Palmer, Cristina Maglio, Carlo Pirazzi, Maria Antonella Burza, Martin Adiels, Lindsay Burch, Louise A Donnelly, Helen Colhoun, Alexander S Doney, John F Dillon, Ewan R Pearson, Mark McCarthy, Andrew T Hattersley, Tim Frayling, Andrew D Morris, Markku Peltonen, Per-Arne Svensson, Peter Jacobson, Jan Borén, Lars Sjöström, Lena M S Carlsson, Stefano Romeo
Published 2012-01-01

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study.

by Valborg Gudmundsdottir, Helle Krogh Pedersen, Karla Viviani Allebrandt, Caroline Brorsson, Nienke van Leeuwen, Karina Banasik, Anubha Mahajan, Christopher J Groves, Martijn van de Bunt, Adem Y Dawed, Andreas Fritsche, Harald Staiger, Annemarie M C Simonis-Bik, Joris Deelen, Mark H H Kramer, Axel Dietrich, Thomas Hübschle, Gonneke Willemsen, Hans-Ulrich Häring, Eco J C de Geus, Dorret I Boomsma, Elisabeth M W Eekhoff, Jorge Ferrer, Mark I McCarthy, Ewan R Pearson, Ramneek Gupta, Søren Brunak, Leen M 't Hart
Published 2018-01-01

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

by Laura J. Corbin, Vanessa Y. Tan, David A. Hughes, Kaitlin H. Wade, Dirk S. Paul, Katherine E. Tansey, Frances Butcher, Frank Dudbridge, Joanna M. Howson, Momodou W. Jallow, Catherine John, Nathalie Kingston, Cecilia M. Lindgren, Michael O’Donavan, Stephen O’Rahilly, Michael J. Owen, Colin N. A. Palmer, Ewan R. Pearson, Robert A. Scott, David A. van Heel, John Whittaker, Tim Frayling, Martin D. Tobin, Louise V. Wain, George Davey Smith, David M. Evans, Fredrik Karpe, Mark I. McCarthy, John Danesh, Paul W. Franks, Nicholas J. Timpson
Published 2018-02-01

Obesity, clinical, and genetic predictors for glycemic progression in Chinese patients with type 2 diabetes: A cohort study using the Hong Kong Diabetes Register and Hong Kong Diab...

by Guozhi Jiang, Andrea O Luk, Claudia H T Tam, Eric S Lau, Risa Ozaki, Elaine Y K Chow, Alice P S Kong, Cadmon K P Lim, Ka Fai Lee, Shing Chung Siu, Grace Hui, Chiu Chi Tsang, Kam Piu Lau, Jenny Y Y Leung, Man-Wo Tsang, Grace Kam, Ip Tim Lau, June K Li, Vincent T Yeung, Emmy Lau, Stanley Lo, Samuel K S Fung, Yuk Lun Cheng, Chun Chung Chow, Ewan R Pearson, Wing Yee So, Juliana C N Chan, Ronald C W Ma, Hong Kong Diabetes Register TRS Study Group, Hong Kong Diabetes Biobank Study Group
Published 2020-07-01

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

by Rebeca Eriksen, Isabel Garcia Perez, Joram M. Posma, Mark Haid, Sapna Sharma, Cornelia Prehn, Louise E. Thomas, Robert W. Koivula, Roberto Bizzotto, Cornelia Prehn, Andrea Mari, Giuseppe N. Giordano, Imre Pavo, Jochen M. Schwenk, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Femke Rutter, Harriet Teare, Tue H. Hansen, Juan Fernandez, Angus Jones, Chris Jennison, Mark Walker, Mark I. McCarthy, Oluf Pedersen, Hartmut Ruetten, Ian Forgie, Jimmy D. Bell, Ewan R. Pearson, Paul W. Franks, Jerzy Adamski, Elaine Holmes, Gary Frost
Published 2020-08-01

Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study.

by Morgan Obura, Joline W J Beulens, Roderick Slieker, Anitra D M Koopman, Trynke Hoekstra, Giel Nijpels, Petra Elders, Robert W Koivula, Azra Kurbasic, Markku Laakso, Tue H Hansen, Martin Ridderstråle, Torben Hansen, Imre Pavo, Ian Forgie, Bernd Jablonka, Hartmut Ruetten, Andrea Mari, Mark I McCarthy, Mark Walker, Alison Heggie, Timothy J McDonald, Mandy H Perry, Federico De Masi, Søren Brunak, Anubha Mahajan, Giuseppe N Giordano, Tarja Kokkola, Emmanouil Dermitzakis, Ana Viñuela, Oluf Pedersen, Jochen M Schwenk, Jurek Adamski, Harriet J A Teare, Ewan R Pearson, Paul W Franks, Leen M 't Hart, Femke Rutters, IMI-DIRECT Consortium
Published 2020-01-01

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts.

by Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Ana Viñuela, Francesca Frau, Hugo Pomares-Millan, Mark Haid, Angus G Jones, E Louise Thomas, Robert W Koivula, Azra Kurbasic, Pascal M Mutie, Hugo Fitipaldi, Juan Fernandez, Adem Y Dawed, Giuseppe N Giordano, Ian M Forgie, Timothy J McDonald, Femke Rutters, Henna Cederberg, Elizaveta Chabanova, Matilda Dale, Federico De Masi, Cecilia Engel Thomas, Kristine H Allin, Tue H Hansen, Alison Heggie, Mun-Gwan Hong, Petra J M Elders, Gwen Kennedy, Tarja Kokkola, Helle Krogh Pedersen, Anubha Mahajan, Donna McEvoy, Francois Pattou, Violeta Raverdy, Ragna S Häussler, Sapna Sharma, Henrik S Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Leen M 't Hart, Jerzy Adamski, Petra B Musholt, Soren Brage, Søren Brunak, Emmanouil Dermitzakis, Gary Frost, Torben Hansen, Markku Laakso, Oluf Pedersen, Martin Ridderstråle, Hartmut Ruetten, Andrew T Hattersley, Mark Walker, Joline W J Beulens, Andrea Mari, Jochen M Schwenk, Ramneek Gupta, Mark I McCarthy, Ewan R Pearson, Jimmy D Bell, Imre Pavo, Paul W Franks
Published 2020-06-01