The genetic architecture of ALS

by Aleksey Shatunov, Ammar Al-Chalabi
Published 2021-01-01

What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved]

by Sarah Martin, Ahmad Al Khleifat, Ammar Al-Chalabi
Published 2017-03-01

Credibility analysis of putative disease-causing genes using bioinformatics.

by Olubunmi Abel, John F Powell, Peter M Andersen, Ammar Al-Chalabi
Published 2013-01-01

A Knowledge-Based Machine Learning Approach to Gene Prioritisation in Amyotrophic Lateral Sclerosis

by Daniel M. Bean, Ammar Al-Chalabi, Richard J. B. Dobson, Alfredo Iacoangeli
Published 2020-06-01

Response to the Letter from Garcia-Montojo and colleagues concerning our paper entitled, Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor c...

by Jeremy A. Garson, Louise Usher, Ammar Al-Chalabi, Jim Huggett, Edmund F. Day, Adele L. McCormick
Published 2019-07-01

Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis

by Jeremy A. Garson, Louise Usher, Ammar Al-Chalabi, Jim Huggett, Edmund F. Day, Adele L. McCormick
Published 2019-03-01

Latent cluster analysis of ALS phenotypes identifies prognostically differing groups.

by Jeban Ganesalingam, Daniel Stahl, Lokesh Wijesekera, Clare Galtrey, Christopher E Shaw, P Nigel Leigh, Ammar Al-Chalabi
Published 2009-09-01

Infection of the central nervous system, sepsis and amyotrophic lateral sclerosis.

by Fang Fang, Honglei Chen, Karin Wirdefeldt, Lars-Olof Ronnevi, Ammar Al-Chalabi, Tracy L Peters, Freya Kamel, Weimin Ye
Published 2011-01-01

A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex

by Ashley R. Jones, Alfredo Iacoangeli, Brett N. Adey, Harry Bowles, Aleksey Shatunov, Claire Troakes, Jeremy A. Garson, Adele L. McCormick, Ammar Al-Chalabi
Published 2021-07-01

The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci.

by Louise V Wain, Inti Pedroso, John E Landers, Gerome Breen, Christopher E Shaw, P Nigel Leigh, Robert H Brown, Martin D Tobin, Ammar Al-Chalabi
Published 2009-12-01

Frequency and methylation status of selected retrotransposition competent L1 loci in amyotrophic lateral sclerosis

by Abigail L. Savage, Ana Illera Lopez, Alfredo Iacoangeli, Vivien J. Bubb, Bradley Smith, Claire Troakes, Nada Alahmady, Sulev Koks, Gerald G. Schumann, Ammar Al-Chalabi, John P. Quinn
Published 2020-11-01

An evaluation of a SVA retrotransposon in the FUS promoter as a transcriptional regulator and its association to ALS.

by Abigail L Savage, Thomas P Wilm, Kejhal Khursheed, Aleksey Shatunov, Karen E Morrison, Pamela J Shaw, Christopher E Shaw, Bradley Smith, Gerome Breen, Ammar Al-Chalabi, Diana Moss, Vivien J Bubb, John P Quinn
Published 2014-01-01

Evolution of white matter damage in amyotrophic lateral sclerosis

by Matt C. Gabel, Rebecca J. Broad, Alexandra L. Young, Sharon Abrahams, Mark E. Bastin, Ricarda A. L. Menke, Ammar Al‐Chalabi, Laura H. Goldstein, Stella Tsermentseli, Daniel C. Alexander, Martin R. Turner, P. Nigel Leigh, Mara Cercignani
Published 2020-05-01

C9orf72 intermediate expansions of 24–30 repeats are associated with ALS

by Alfredo Iacoangeli, Ahmad Al Khleifat, Ashley R. Jones, William Sproviero, Aleksey Shatunov, Sarah Opie-Martin, Alzheimer’s Disease Neuroimaging Initiative, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, Isabella Fogh, Richard J. Dobson, Stephen J. Newhouse, Ammar Al-Chalabi
Published 2019-07-01

Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.

by Ammar Al-Chalabi, Alexandra Dürr, Nicholas W Wood, Michael H Parkinson, Agnes Camuzat, Jean-Sébastien Hulot, Karen E Morrison, Alan Renton, Sigurd D Sussmuth, Bernhard G Landwehrmeyer, Albert Ludolph, Yves Agid, Alexis Brice, P Nigel Leigh, Gilbert Bensimon, NNIPPS Genetic Study Group
Published 2009-09-01

Genetic ablation of phospholipase C delta 1 increases survival in SOD1G93A mice

by Kim A. Staats, Lawrence Van Helleputte, Ashley R. Jones, André Bento-Abreu, Annelies Van Hoecke, Aleksey Shatunov, Claire L. Simpson, Robin Lemmens, Tom Jaspers, Kiyoko Fukami, Yoshikazu Nakamura, Robert H. Brown, Jr., Philip Van Damme, Adrian Liston, Wim Robberecht, Ammar Al-Chalabi, Ludo Van Den Bosch
Published 2013-12-01

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

by Russell L. McLaughlin, Dick Schijven, Wouter van Rheenen, Kristel R. van Eijk, Margaret O’Brien, René S. Kahn, Roel A. Ophoff, An Goris, Daniel G. Bradley, Ammar Al-Chalabi, Leonard H. van den Berg, Jurjen J. Luykx, Orla Hardiman, Jan H. Veldink, Project MinE GWAS Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium
Published 2017-03-01

Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases

by Jason A. Chen, Zhongbo Chen, Hyejung Won, Alden Y. Huang, Jennifer K. Lowe, Kevin Wojta, Jennifer S. Yokoyama, Gilbert Bensimon, P. Nigel Leigh, Christine Payan, Aleksey Shatunov, Ashley R. Jones, Cathryn M. Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-Francois Dartigues, Albert Ludolph, Adam L. Boxer, Jeff M. Bronstein, Ammar Al-Chalabi, Daniel H. Geschwind, Giovanni Coppola
Published 2018-08-01

Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk Gene

by Johnathan Cooper-Knock, Sai Zhang, Kevin P. Kenna, Tobias Moll, John P. Franklin, Samantha Allen, Helia Ghahremani Nezhad, Alfredo Iacoangeli, Nancy Y. Yacovzada, Chen Eitan, Eran Hornstein, Eran Ehilak, Petra Celadova, Daniel Bose, Sali Farhan, Simon Fishilevich, Doron Lancet, Karen E. Morrison, Christopher E. Shaw, Ammar Al-Chalabi, Jan H. Veldink, Janine Kirby, Michael P. Snyder, Pamela J. Shaw, Ian Blair, Naomi Wray, Matthew Kiernan, Miguel Mitne Neto, Adriano Chio, Ruben Cauchi, Wim Robberecht, Philip van Damme, Phillippe Corcia, Phillipe Couratier, Orla Hardiman, Russel McLaughlin, Marc Gotkine, Vivan Drory, Nicola Ticozzi, Vincenzo Silani, Jan Veldink, Leonard van den Berg, Mamede de Carvalho, Jesus Mora Pardina, Monica Povedano, Peter Andersen, Markus Wber, Nazli Başak, Ammar Al-Chalabi, Christopher Shaw, Pamela Shaw, Karen Morrison, John Landers, Jonathan Glass
Published 2020-12-01

Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.

by Frank P Diekstra, Christiaan G J Saris, Wouter van Rheenen, Lude Franke, Ritsert C Jansen, Michael A van Es, Paul W J van Vught, Hylke M Blauw, Ewout J N Groen, Steve Horvath, Karol Estrada, Fernando Rivadeneira, Albert Hofman, Andre G Uitterlinden, Wim Robberecht, Peter M Andersen, Judith Melki, Vincent Meininger, Orla Hardiman, John E Landers, Robert H Brown, Aleksey Shatunov, Christopher E Shaw, P Nigel Leigh, Ammar Al-Chalabi, Roel A Ophoff, Leonard H van den Berg, Jan H Veldink
Published 2012-01-01