Failure to Deliver and Translate—New Insights into RNA Dysregulation in ALS

by Alyssa N. Coyne, Alyssa N. Coyne, Benjamin L. Zaepfel, Daniela C. Zarnescu, Daniela C. Zarnescu, Daniela C. Zarnescu
Published 2017-08-01

A Helping Hand: RNA-Binding Proteins Guide Gene-Binding Choices by Cohesin Complexes.

by Alyssa N Coyne, Daniela C Zarnescu
Published 2016-11-01

Medium-Chain Fatty Acids, Beta-Hydroxybutyric Acid and Genetic Modulation of the Carnitine Shuttle Are Protective in a Drosophila Model of ALS Based on TDP-43

by Ernesto Manzo, Abigail G. O'Conner, Jordan M. Barrows, Dakotah D. Shreiner, Gabriel J. Birchak, Daniela C. Zarnescu, Daniela C. Zarnescu, Daniela C. Zarnescu
Published 2018-05-01

To Be or Not To Be…Toxic—Is RNA Association With TDP-43 Complexes Deleterious or Protective in Neurodegeneration?

by Suvithanandhini Loganathan, Erik M. Lehmkuhl, Randall J. Eck, Randall J. Eck, Daniela C. Zarnescu, Daniela C. Zarnescu
Published 2020-01-01

-2019 PLOS Genetics Research Prize: Fruit fly school - language and dialects for communicating a threat.

by Gregory S Barsh, Gregory P Copenhaver, Elapulli Sankaranarayanan Prakash, Daniela C Zarnescu
Published 2019-09-01

Regulation of Heart Rate in Drosophila via Fragile X Mental Retardation Protein.

by Stefanie Mares Novak, Archi Joardar, Carol C Gregorio, Daniela C Zarnescu
Published 2015-01-01

Endocytosis regulates TDP-43 toxicity and turnover

by Guangbo Liu, Alyssa N. Coyne, Fen Pei, Spencer Vaughan, Matthew Chaung, Daniela C. Zarnescu, J. Ross Buchan
Published 2017-12-01

Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis

by Patricia S. Estes, Scott G. Daniel, Abigail P. Mccallum, Ashley V. Boehringer, Alona S. Sukhina, Rebecca A. Zwick, Daniela C. Zarnescu
Published 2013-05-01

miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila

by Scott G. Daniel, Atlantis D. Russ, Kathryn M. Guthridge, Ammad I. Raina, Patricia S. Estes, Linda M. Parsons, Helena E. Richardson, Joyce A. Schroeder, Daniela C. Zarnescu
Published 2018-01-01

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

by Alyssa N. Coyne, Ileana Lorenzini, Ching-Chieh Chou, Meaghan Torvund, Robert S. Rogers, Alexander Starr, Benjamin L. Zaepfel, Jennifer Levy, Jeffrey Johannesmeyer, Jacob C. Schwartz, Hiroshi Nishimune, Konrad Zinsmaier, Wilfried Rossoll, Rita Sattler, Daniela C. Zarnescu
Published 2017-10-01

Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS

by Ernesto Manzo, Ileana Lorenzini, Dianne Barrameda, Abigail G O'Conner, Jordan M Barrows, Alexander Starr, Tina Kovalik, Benjamin E Rabichow, Erik M Lehmkuhl, Dakotah D Shreiner, Archi Joardar, Jean-Charles Liévens, Robert Bowser, Rita Sattler, Daniela C Zarnescu
Published 2019-06-01

TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6

by Erik M. Lehmkuhl, Suvithanandhini Loganathan, Eric Alsop, Alexander D. Blythe, Tina Kovalik, Nicholas P. Mortimore, Dianne Barrameda, Chuol Kueth, Randall J. Eck, Bhavani B. Siddegowda, Archi Joardar, Hannah Ball, Maria E. Macias, Robert Bowser, Kendall Van Keuren-Jensen, Daniela C. Zarnescu
Published 2021-03-01

The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease

by Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen-Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser
Published 2021-02-01