ACE: a probabilistic model for characterizing gene-level essentiality in CRISPR screens

by Elizabeth R. Hutton, Christopher R. Vakoc, Adam Siepel
Published 2021-09-01

BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements

by Anand S. Bhagwat, Jae-Seok Roe, Beverly Y.L. Mok, Anja F. Hohmann, Junwei Shi, Christopher R. Vakoc
Published 2016-04-01

Acquired Dependence of Acute Myeloid Leukemia on the DEAD-Box RNA Helicase DDX5

by Anthony Mazurek, Youngkyu Park, Cornelius Miething, John E. Wilkinson, Jesse Gillis, Scott W. Lowe, Christopher R. Vakoc, Bruce Stillman
Published 2014-06-01

Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis.

by Jonathan J Ipsaro, Chen Shen, Eri Arai, Yali Xu, Justin B Kinney, Leemor Joshua-Tor, Christopher R Vakoc, Junwei Shi
Published 2017-01-01

The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer

by Eric Wang, Shinpei Kawaoka, Jae-Seok Roe, Junwei Shi, Anja F Hohmann, Yali Xu, Anand S Bhagwat, Yutaka Suzuki, Justin B Kinney, Christopher R Vakoc
Published 2015-04-01

Tankyrase inhibition sensitizes cells to CDK4 blockade.

by Miguel Foronda, Yusuke Tarumoto, Emma M Schatoff, Benjamin I Leach, Bianca J Diaz, Jill Zimmerman, Sukanya Goswami, Michael Shusterman, Christopher R Vakoc, Lukas E Dow
Published 2019-01-01

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

by Tim D.D. Somerville, Yali Xu, Koji Miyabayashi, Hervé Tiriac, Cristian R. Cleary, Diogo Maia-Silva, Joseph P. Milazzo, David A. Tuveson, Christopher R. Vakoc
Published 2018-11-01

The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

by Hsiang-Chen Chou, Kuhulika Bhalla, Osama EL Demerdesh, Olaf Klingbeil, Kaarina Hanington, Sergey Aganezov, Peter Andrews, Habeeb Alsudani, Kenneth Chang, Christopher R Vakoc, Michael C Schatz, W Richard McCombie, Bruce Stillman
Published 2021-02-01

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

by Sumiko Takao, Lauren Forbes, Masahiro Uni, Shuyuan Cheng, Jose Mario Bello Pineda, Yusuke Tarumoto, Paolo Cifani, Gerard Minuesa, Celine Chen, Michael G Kharas, Robert K Bradley, Christopher R Vakoc, Richard P Koche, Alex Kentsis
Published 2021-02-01

Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage

by Berkley E. Gryder, Marco Wachtel, Kenneth Chang, Osama El Demerdash, Nicholas G. Aboreden, Wardah Mohammed, Winston Ewert, Silvia Pomella, Rossella Rota, Jun S. Wei, Young Song, Benjamin Z. Stanton, Beat Schäfer, Christopher R. Vakoc, Javed Khan
Published 2020-05-01

Author Correction: Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

by Francisco Caiado, Diogo Maia-Silva, Carolina Jardim, Nina Schmolka, Tânia Carvalho, Cláudia Reforço, Rita Faria, Branka Kolundzija, André E. Simões, Tuncay Baubec, Christopher R. Vakoc, Maria Gomes da Silva, Markus G. Manz, Ton N. Schumacher, Håkan Norell, Bruno Silva-Santos
Published 2019-11-01

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma

by Gerard L Brien, David Remillard, Junwei Shi, Matthew L Hemming, Jonathon Chabon, Kieran Wynne, Eugène T Dillon, Gerard Cagney, Guido Van Mierlo, Marijke P Baltissen, Michiel Vermeulen, Jun Qi, Stefan Fröhling, Nathanael S Gray, James E Bradner, Christopher R Vakoc, Scott A Armstrong
Published 2018-11-01

Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

by Francisco Caiado, Diogo Maia-Silva, Carolina Jardim, Nina Schmolka, Tânia Carvalho, Cláudia Reforço, Rita Faria, Branka Kolundzija, André E. Simões, Tuncay Baubec, Christopher R. Vakoc, Maria Gomes da Silva, Markus G. Manz, Ton N. Schumacher, Håkan Norell, Bruno Silva-Santos
Published 2019-11-01

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

by Tim DD Somerville, Giulia Biffi, Juliane Daßler-Plenker, Stella K Hur, Xue-Yan He, Krysten E Vance, Koji Miyabayashi, Yali Xu, Diogo Maia-Silva, Olaf Klingbeil, Osama E Demerdash, Jonathan B Preall, Michael A Hollingsworth, Mikala Egeblad, David A Tuveson, Christopher R Vakoc
Published 2020-04-01

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

by Anna Skucha, Jessica Ebner, Johannes Schmöllerl, Mareike Roth, Thomas Eder, Adrián César-Razquin, Alexey Stukalov, Sarah Vittori, Matthias Muhar, Bin Lu, Martin Aichinger, Julian Jude, André C. Müller, Balázs Győrffy, Christopher R. Vakoc, Peter Valent, Keiryn L. Bennett, Johannes Zuber, Giulio Superti-Furga, Florian Grebien
Published 2018-05-01

Superior efficacy of co-targeting GFI1/KDM1A and BRD4 against AML and post-MPN secondary AML cells

by Warren Fiskus, Christopher P. Mill, Behnam Nabet, Dimuthu Perera, Christine Birdwell, Taghi Manshouri, Bernardo Lara, Tapan M. Kadia, Courtney DiNardo, Koichi Takahashi, Naval Daver, Prithviraj Bose, Lucia Masarova, Naveen Pemmaraju, Steven Kornblau, Gautam Borthakur, Guillermo Montalban-Bravo, Guillermo Garcia Manero, Sunil Sharma, Matthew Stubbs, Xiaoping Su, Michael R. Green, Cristian Coarfa, Srdan Verstovsek, Joseph D. Khoury, Christopher R. Vakoc, Kapil N. Bhalla
Published 2021-05-01

Preclinical rationale for entinostat in embryonal rhabdomyosarcoma

by Narendra Bharathy, Noah E. Berlow, Eric Wang, Jinu Abraham, Teagan P. Settelmeyer, Jody E. Hooper, Matthew N. Svalina, Zia Bajwa, Martin W. Goros, Brian S. Hernandez, Johannes E. Wolff, Ranadip Pal, Angela M. Davies, Arya Ashok, Darnell Bushby, Maria Mancini, Christopher Noakes, Neal C. Goodwin, Peter Ordentlich, James Keck, Douglas S. Hawkins, Erin R. Rudzinski, Atiya Mansoor, Theodore J. Perkins, Christopher R. Vakoc, Joel E. Michalek, Charles Keller
Published 2019-05-01

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

by Erin R. Aho, Jing Wang, Rocco D. Gogliotti, Gregory C. Howard, Jason Phan, Pankaj Acharya, Jonathan D. Macdonald, Ken Cheng, Shelly L. Lorey, Bin Lu, Sabine Wenzel, Audra M. Foshage, Joseph Alvarado, Feng Wang, J. Grace Shaw, Bin Zhao, April M. Weissmiller, Lance R. Thomas, Christopher R. Vakoc, Matthew D. Hall, Scott W. Hiebert, Qi Liu, Shaun R. Stauffer, Stephen W. Fesik, William P. Tansey
Published 2019-03-01

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

by Charles C. Bell, Katie A. Fennell, Yih-Chih Chan, Florian Rambow, Miriam M. Yeung, Dane Vassiliadis, Luis Lara, Paul Yeh, Luciano G. Martelotto, Aljosja Rogiers, Brandon E. Kremer, Olena Barbash, Helai P. Mohammad, Timothy M. Johanson, Marian L. Burr, Arindam Dhar, Natalie Karpinich, Luyi Tian, Dean S. Tyler, Laura MacPherson, Junwei Shi, Nathan Pinnawala, Chun Yew Fong, Anthony T. Papenfuss, Sean M. Grimmond, Sarah-Jane Dawson, Rhys S. Allan, Ryan G. Kruger, Christopher R. Vakoc, David L. Goode, Shalin H. Naik, Omer Gilan, Enid Y. N. Lam, Jean-Christophe Marine, Rab K. Prinjha, Mark A. Dawson
Published 2019-06-01