In Vivo Pharmacodynamic Imaging of Proteasome Inhibition

by Erin A. Kimbrel, Tina N. Davis, James E. Bradner, Andrew L. Kung
Published 2009-05-01

Correction: Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells.

by Trent Fowler, Payel Ghatak, David H Price, Ronald Conaway, Joan Conaway, Cheng-Ming Chiang, James E Bradner, Ali Shilatifard, Ananda L Roy
Published 2015-01-01

Regulation of MYC expression and differential JQ1 sensitivity in cancer cells.

by Trent Fowler, Payel Ghatak, David H Price, Ronald Conaway, Joan Conaway, Cheng-Ming Chiang, James E Bradner, Ali Shilatifard, Ananda L Roy
Published 2014-01-01

Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

by Aline Gaub, Bilal N. Sheikh, M. Felicia Basilicata, Marie Vincent, Mathilde Nizon, Cindy Colson, Matthew J. Bird, James E. Bradner, Julien Thevenon, Michael Boutros, Asifa Akhtar
Published 2020-05-01

Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome

by David A. Orlando, Mei Wei Chen, Victoria E. Brown, Snehakumari Solanki, Yoon J. Choi, Eric R. Olson, Christian C. Fritz, James E. Bradner, Matthew G. Guenther
Published 2014-11-01

Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape

by Behnam Nabet, Pilib Ó Broin, Jaime M. Reyes, Kevin Shieh, Charles Y. Lin, Christine M. Will, Relja Popovic, Teresa Ezponda, James E. Bradner, Aaron A. Golden, Jonathan D. Licht
Published 2015-08-01

The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitorsResearch in context

by Aubrey L. Miller, Samuel C. Fehling, Patrick L. Garcia, Tracy L. Gamblin, Leona N. Council, Robert C.A.M. van Waardenburg, Eddy S. Yang, James E. Bradner, Karina J. Yoon
Published 2019-06-01

BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression

by Hengrui Zhu, Fee Bengsch, Nikolaos Svoronos, Melanie R. Rutkowski, Benjamin G. Bitler, Michael J. Allegrezza, Yuhki Yokoyama, Andrew V. Kossenkov, James E. Bradner, Jose R. Conejo-Garcia, Rugang Zhang
Published 2016-09-01

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA

by Matthew S. Stratton, Charles Y. Lin, Priti Anand, Philip D. Tatman, Bradley S. Ferguson, Sean T. Wickers, Amrut V. Ambardekar, Carmen C. Sucharov, James E. Bradner, Saptarsi M. Haldar, Timothy A. McKinsey
Published 2016-08-01

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

by Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong, Miljan Kuljanin, Alan L. Leggett, Mikaela L. Mohardt, Amanda Robichaud, Amy S. Conway, Dennis L. Buckley, Joseph D. Mancias, James E. Bradner, Kimberly Stegmaier, Nathanael S. Gray
Published 2020-09-01

Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma

by Mariateresa Fulciniti, Charles Y. Lin, Mehmet K. Samur, Michael A. Lopez, Irtisha Singh, Matthew A. Lawlor, Raphael E. Szalat, Christopher J. Ott, Herve’ Avet-Loiseau, Kenneth C. Anderson, Richard A. Young, James E. Bradner, Nikhil C. Munshi
Published 2018-12-01

The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53

by Joanna S. Yi, Oscar Sias-Garcia, Nicole Nasholm, Xiaoyu Hu, Amanda Balboni Iniguez, Matthew D. Hall, Mindy Davis, Rajarshi Guha, Myrthala Moreno-Smith, Eveline Barbieri, Kevin Duong, Jessica Koach, Jun Qi, James E. Bradner, Kimberly Stegmaier, William A. Weiss, W. Clay Gustafson
Published 2021-06-01

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma

by Gerard L Brien, David Remillard, Junwei Shi, Matthew L Hemming, Jonathon Chabon, Kieran Wynne, Eugène T Dillon, Gerard Cagney, Guido Van Mierlo, Marijke P Baltissen, Michiel Vermeulen, Jun Qi, Stefan Fröhling, Nathanael S Gray, James E Bradner, Christopher R Vakoc, Scott A Armstrong
Published 2018-11-01

High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML

by Yue Zhao, Qi Liu, Pankaj Acharya, Kristy R. Stengel, Quanhu Sheng, Xiaofan Zhou, Hojoong Kwak, Melissa A. Fischer, James E. Bradner, Stephen A. Strickland, Sanjay R. Mohan, Michael R. Savona, Bryan J. Venters, Ming-Ming Zhou, John T. Lis, Scott W. Hiebert
Published 2016-08-01

PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

by Melusine Bleu, Swann Gaulis, Rui Lopes, Kathleen Sprouffske, Verena Apfel, Sjoerd Holwerda, Marco Pregnolato, Umut Yildiz, Valentina Cordoʹ, Antonella F. M. Dost, Judith Knehr, Walter Carbone, Felix Lohmann, Charles Y. Lin, James E. Bradner, Audrey Kauffmann, Luca Tordella, Guglielmo Roma, Giorgio G. Galli
Published 2019-08-01

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

by Simon J. Hogg, Stephin J. Vervoort, Sumit Deswal, Christopher J. Ott, Jason Li, Leonie A. Cluse, Paul A. Beavis, Phillip K. Darcy, Benjamin P. Martin, Andrew Spencer, Anna K. Traunbauer, Irina Sadovnik, Karin Bauer, Peter Valent, James E. Bradner, Johannes Zuber, Jake Shortt, Ricky W. Johnstone
Published 2017-02-01

MELK is not necessary for the proliferation of basal-like breast cancer cells

by Hai-Tsang Huang, Hyuk-Soo Seo, Tinghu Zhang, Yubao Wang, Baishan Jiang, Qing Li, Dennis L Buckley, Behnam Nabet, Justin M Roberts, Joshiawa Paulk, Shiva Dastjerdi, Georg E Winter, Hilary McLauchlan, Jennifer Moran, James E Bradner, Michael J Eck, Sirano Dhe-Paganon, Jean J Zhao, Nathanael S Gray
Published 2017-09-01

Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.

by Jingwei Cheng, Donglim Esther Park, Christian Berrios, Elizabeth A White, Reety Arora, Rosa Yoon, Timothy Branigan, Tengfei Xiao, Thomas Westerling, Alexander Federation, Rhamy Zeid, Benjamin Strober, Selene K Swanson, Laurence Florens, James E Bradner, Myles Brown, Peter M Howley, Megha Padi, Michael P Washburn, James A DeCaprio
Published 2017-10-01

Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

by Andrea J. Cohen, Alina Saiakhova, Olivia Corradin, Jennifer M. Luppino, Katreya Lovrenert, Cynthia F. Bartels, James J. Morrow, Stephen C. Mack, Gursimran Dhillon, Lydia Beard, Lois Myeroff, Matthew F. Kalady, Joseph Willis, James E. Bradner, Ruth A. Keri, Nathan A. Berger, Shondra M. Pruett-Miller, Sanford D. Markowitz, Peter C. Scacheri
Published 2017-02-01

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

by David P. Labbé, Giorgia Zadra, Meng Yang, Jaime M. Reyes, Charles Y. Lin, Stefano Cacciatore, Ericka M. Ebot, Amanda L. Creech, Francesca Giunchi, Michelangelo Fiorentino, Habiba Elfandy, Sudeepa Syamala, Edward D. Karoly, Mohammed Alshalalfa, Nicholas Erho, Ashley Ross, Edward M. Schaeffer, Ewan A. Gibb, Mandeep Takhar, Robert B. Den, Jonathan Lehrer, R. Jeffrey Karnes, Stephen J. Freedland, Elai Davicioni, Daniel E. Spratt, Leigh Ellis, Jacob D. Jaffe, Anthony V. DʼAmico, Philip W. Kantoff, James E. Bradner, Lorelei A. Mucci, Jorge E. Chavarro, Massimo Loda, Myles Brown
Published 2019-09-01