Pharmacokinetics and immunogenicity of broadly neutralizing HIV monoclonal antibodies in macaques.

by Yvonne Rosenberg, Markus Sack, David Montefiori, Celia Labranche, Mark Lewis, Lori Urban, Lingjun Mao, Rainer Fischer, Xiaoming Jiang
Published 2015-01-01

Characterization of a Large Panel of Rabbit Monoclonal Antibodies against HIV-1 gp120 and Isolation of Novel Neutralizing Antibodies against the V3 Loop.

by Yali Qin, Saikat Banerjee, Aditi Agrawal, Heliang Shi, Marisa Banasik, Feng Lin, Kari Rohl, Celia LaBranche, David C Montefiori, Michael W Cho
Published 2015-01-01

Immunization of rabbits with highly purified, soluble, trimeric human immunodeficiency virus type 1 envelope glycoprotein induces a vigorous B cell response and broadly cross-react...

by Gerald V Quinnan, Olusegun Onabajo, Pengfei Zhang, Lianying Yan, Joseph J Mattapallil, Zhiqiang Zhang, Ming Dong, Min Lu, David Montefiori, Celia LaBranche, Christopher C Broder
Published 2014-01-01

Stabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoprotein.

by Aemro Kassa, Antu K Dey, Pampi Sarkar, Celia Labranche, Eden P Go, Daniel F Clark, Yide Sun, Avishek Nandi, Karin Hartog, Heather Desaire, David Montefiori, Andrea Carfi, Indresh K Srivastava, Susan W Barnett
Published 2013-01-01

Comparison of neutralizing antibody responses elicited from highly diverse polyvalent heterotrimeric HIV-1 gp140 cocktail immunogens versus a monovalent counterpart in rhesus macaq...

by Emma J Bowles, Torben Schiffner, Maximillian Rosario, Gemma A Needham, Meghna Ramaswamy, Joanna McGouran, Benedikt Kessler, Celia LaBranche, Andrew J McMichael, David Montefiori, Quentin J Sattentau, Tomáš Hanke, Guillaume B E Stewart-Jones
Published 2014-01-01

9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity.

by James J Kobie, Danielle C Alcena, Bo Zheng, Peter Bryk, Jonelle L Mattiacio, Matthew Brewer, Celia Labranche, Faith M Young, Stephen Dewhurst, David C Montefiori, Alexander F Rosenberg, Changyong Feng, Xia Jin, Michael C Keefer, Ignacio Sanz
Published 2012-01-01

Generation and Characterization of a Bivalent HIV-1 Subtype C gp120 Protein Boost for Proof-of-Concept HIV Vaccine Efficacy Trials in Southern Africa.

by Carlo Zambonelli, Antu K Dey, Susan Hilt, Samuel Stephenson, Eden P Go, Daniel F Clark, Mark Wininger, Celia Labranche, David Montefiori, Hua-Xin Liao, Ronald I Swanstrom, Heather Desaire, Barton F Haynes, Andrea Carfi, Susan W Barnett
Published 2016-01-01

Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIVmac251 Rectal Challenge.

by Iskra Tuero, Venkatramanan Mohanram, Thomas Musich, Leia Miller, Diego A Vargas-Inchaustegui, Thorsten Demberg, David Venzon, Irene Kalisz, V S Kalyanaraman, Ranajit Pal, Maria Grazia Ferrari, Celia LaBranche, David C Montefiori, Mangala Rao, Monica Vaccari, Genoveffa Franchini, Susan W Barnett, Marjorie Robert-Guroff
Published 2015-08-01

Pre-clinical development of a recombinant, replication-competent adenovirus serotype 4 vector vaccine expressing HIV-1 envelope 1086 clade C.

by Jeff Alexander, Jason Mendy, Lo Vang, Jenny B Avanzini, Fermin Garduno, Darly J Manayani, Glenn Ishioka, Peggy Farness, Li-Hua Ping, Ronald Swanstrom, Robert Parks, Hua-Xin Liao, Barton F Haynes, David C Montefiori, Celia LaBranche, Jonathan Smith, Marc Gurwith, Tim Mayall
Published 2013-01-01

Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization

by K. Rachael Parks, Anna J. MacCamy, Josephine Trichka, Matthew Gray, Connor Weidle, Andrew J. Borst, Arineh Khechaduri, Brittany Takushi, Parul Agrawal, Javier Guenaga, Richard T. Wyatt, Rhea Coler, Michael Seaman, Celia LaBranche, David C. Montefiori, David Veesler, Marie Pancera, Andrew McGuire, Leonidas Stamatatos
Published 2019-12-01

DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques.

by Rashmi Jalah, Viraj Kulkarni, Vainav Patel, Margherita Rosati, Candido Alicea, Jenifer Bear, Lei Yu, Yongjun Guan, Xiaoying Shen, Georgia D Tomaras, Celia LaBranche, David C Montefiori, Rajasekhar Prattipati, Abraham Pinter, Julian Bess, Jeffrey D Lifson, Steven G Reed, Niranjan Y Sardesai, David J Venzon, Antonio Valentin, George N Pavlakis, Barbara K Felber
Published 2014-01-01

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

by Philip J. M. Brouwer, Aleksandar Antanasijevic, Marlon de Gast, Joel D. Allen, Tom P. L. Bijl, Anila Yasmeen, Rashmi Ravichandran, Judith A. Burger, Gabriel Ozorowski, Jonathan L. Torres, Celia LaBranche, David C. Montefiori, Rajesh P. Ringe, Marit J. van Gils, John P. Moore, Per Johan Klasse, Max Crispin, Neil P. King, Andrew B. Ward, Rogier W. Sanders
Published 2021-02-01

Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

by David R. Martinez, Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, Juilin Chen, Michael Mengual, Ayooluwa O. Douglas, Holly Heimsath, Kevin O. Saunders, Nathan I. Nicely, Joshua Eudailey, Giovanna Hernandez, Papa Kwadwo Morgan-Asiedu, Kevin Wiehe, Barton F. Haynes, M. Anthony Moody, Celia LaBranche, David C. Montefiori, Feng Gao, Sallie R. Permar
Published 2020-03-01

Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.

by Fangping Cai, Wei-Hung Chen, Weimin Wu, Julia A Jones, Misook Choe, Neelakshi Gohain, Xiaoying Shen, Celia LaBranche, Amanda Eaton, Laura Sutherland, Esther M Lee, Giovanna E Hernandez, Nelson R Wu, Richard Scearce, Michael S Seaman, M Anthony Moody, Sampa Santra, Kevin Wiehe, Georgia D Tomaras, Kshitij Wagh, Bette Korber, Mattia Bonsignori, David C Montefiori, Barton F Haynes, Natalia de Val, M Gordon Joyce, Kevin O Saunders
Published 2021-06-01

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.

by Ema T Crooks, Tommy Tong, Bimal Chakrabarti, Kristin Narayan, Ivelin S Georgiev, Sergey Menis, Xiaoxing Huang, Daniel Kulp, Keiko Osawa, Janelle Muranaka, Guillaume Stewart-Jones, Joanne Destefano, Sijy O'Dell, Celia LaBranche, James E Robinson, David C Montefiori, Krisha McKee, Sean X Du, Nicole Doria-Rose, Peter D Kwong, John R Mascola, Ping Zhu, William R Schief, Richard T Wyatt, Robert G Whalen, James M Binley
Published 2015-05-01

Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques.

by Gerard Zurawski, Sandra Zurawski, Anne-Laure Flamar, Laura Richert, Ralf Wagner, Georgia D Tomaras, David C Montefiori, Mario Roederer, Guido Ferrari, Christine Lacabaratz, Henri Bonnabau, Peter Klucar, Zhiqing Wang, Kathryn E Foulds, Shing-Fen Kao, Nicole L Yates, Celia LaBranche, Bertram L Jacobs, Karen Kibler, Benedikt Asbach, Alexander Kliche, Andres Salazar, Steve Reed, Steve Self, Raphael Gottardo, Lindsey Galmin, Deborah Weiss, Anthony Cristillo, Rodolphe Thiebaut, Giuseppe Pantaleo, Yves Levy
Published 2016-01-01

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.

by Christopher A Cottrell, Jelle van Schooten, Charles A Bowman, Meng Yuan, David Oyen, Mia Shin, Robert Morpurgo, Patricia van der Woude, Mariëlle van Breemen, Jonathan L Torres, Raj Patel, Justin Gross, Leigh M Sewall, Jeffrey Copps, Gabriel Ozorowski, Bartek Nogal, Devin Sok, Eva G Rakasz, Celia Labranche, Vladimir Vigdorovich, Scott Christley, Diane G Carnathan, D Noah Sather, David Montefiori, Guido Silvestri, Dennis R Burton, John P Moore, Ian A Wilson, Rogier W Sanders, Andrew B Ward, Marit J van Gils
Published 2020-08-01

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

by Alba Torrents de la Peña, Jean-Philippe Julien, Steven W. de Taeye, Fernando Garces, Miklos Guttman, Gabriel Ozorowski, Laura K. Pritchard, Anna-Janina Behrens, Eden P. Go, Judith A. Burger, Edith E. Schermer, Kwinten Sliepen, Thomas J. Ketas, Pavel Pugach, Anila Yasmeen, Christopher A. Cottrell, Jonathan L. Torres, Charlotte D. Vavourakis, Marit J. van Gils, Celia LaBranche, David C. Montefiori, Heather Desaire, Max Crispin, Per Johan Klasse, Kelly K. Lee, John P. Moore, Andrew B. Ward, Ian A. Wilson, Rogier W. Sanders
Published 2017-08-01

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

by Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker, Neil P. King, Rogier W. Sanders, John P. Moore, Shane Crotty, Max Crispin, David C. Montefiori, Dennis R. Burton, William R. Schief, Guido Silvestri, Andrew B. Ward
Published 2021-08-01

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

by Philip J. M. Brouwer, Aleksandar Antanasijevic, Zachary Berndsen, Anila Yasmeen, Brooke Fiala, Tom P. L. Bijl, Ilja Bontjer, Jacob B. Bale, William Sheffler, Joel D. Allen, Anna Schorcht, Judith A. Burger, Miguel Camacho, Daniel Ellis, Christopher A. Cottrell, Anna-Janina Behrens, Marco Catalano, Iván del Moral-Sánchez, Thomas J. Ketas, Celia LaBranche, Marit J. van Gils, Kwinten Sliepen, Lance J. Stewart, Max Crispin, David C. Montefiori, David Baker, John P. Moore, Per Johan Klasse, Andrew B. Ward, Neil P. King, Rogier W. Sanders
Published 2019-09-01