Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies.

by Yu Feng, Karen Tran, Shridhar Bale, Shailendra Kumar, Javier Guenaga, Richard Wilson, Natalia de Val, Heather Arendt, Joanne DeStefano, Andrew B Ward, Richard T Wyatt
Published 2016-08-01

A novel, live-attenuated vesicular stomatitis virus vector displaying conformationally intact, functional HIV-1 envelope trimers that elicits potent cellular and humoral responses...

by Svetlana Rabinovich, Rebecca L R Powell, Ross W B Lindsay, Maoli Yuan, Alexei Carpov, Aaron Wilson, Mary Lopez, John W Coleman, Denise Wagner, Palka Sharma, Marina Kemelman, Kevin J Wright, John P Seabrook, Heather Arendt, Jennifer Martinez, Joanne DeStefano, Maria J Chiuchiolo, Christopher L Parks
Published 2014-01-01

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.

by Ema T Crooks, Tommy Tong, Bimal Chakrabarti, Kristin Narayan, Ivelin S Georgiev, Sergey Menis, Xiaoxing Huang, Daniel Kulp, Keiko Osawa, Janelle Muranaka, Guillaume Stewart-Jones, Joanne Destefano, Sijy O'Dell, Celia LaBranche, James E Robinson, David C Montefiori, Krisha McKee, Sean X Du, Nicole Doria-Rose, Peter D Kwong, John R Mascola, Ping Zhu, William R Schief, Richard T Wyatt, Robert G Whalen, James M Binley
Published 2015-05-01