Predicting binding to p-glycoprotein by flexible receptor docking.

by Elena Dolghih, Clifford Bryant, Adam R Renslo, Matthew P Jacobson
Published 2011-06-01

Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system.

by Yaneth Osorio, Bruno L Travi, Adam R Renslo, Alex G Peniche, Peter C Melby
Published 2011-01-01

cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool

by Vladimir Camarena, David W Sant, Tyler C Huff, Sushmita Mustafi, Ryan K Muir, Allegra T Aron, Christopher J Chang, Adam R Renslo, Paula V Monje, Gaofeng Wang
Published 2017-12-01

Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

by Mari Nishino, Jonathan W Choy, Nathan N Gushwa, Juan A Oses-Prieto, Kyriacos Koupparis, Alma L Burlingame, Adam R Renslo, James H McKerrow, Jack Taunton
Published 2013-07-01

Correction: Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

by Mari Nishino, Jonathan W Choy, Nathan N Gushwa, Juan A Oses-Prieto, Kyriacos Koupparis, Alma L Burlingame, Adam R Renslo, James H McKerrow, Jack Taunton
Published 2013-07-01

Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.

by Maha-Hamadien Abdulla, Debbie S Ruelas, Brian Wolff, June Snedecor, Kee-Chong Lim, Fengyun Xu, Adam R Renslo, Janice Williams, James H McKerrow, Conor R Caffrey
Published 2009-07-01

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

by Ciara M Gallagher, Carolina Garri, Erica L Cain, Kenny Kean-Hooi Ang, Christopher G Wilson, Steven Chen, Brian R Hearn, Priyadarshini Jaishankar, Andres Aranda-Diaz, Michelle R Arkin, Adam R Renslo, Peter Walter
Published 2016-07-01

Mining a cathepsin inhibitor library for new antiparasitic drug leads.

by Kenny K H Ang, Joseline Ratnam, Jiri Gut, Jennifer Legac, Elizabeth Hansell, Zachary B Mackey, Katarzyna M Skrzypczynska, Anjan Debnath, Juan C Engel, Philip J Rosenthal, James H McKerrow, Michelle R Arkin, Adam R Renslo
Published 2011-01-01

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

by Carmela Sidrauski, Jordan C Tsai, Martin Kampmann, Brian R Hearn, Punitha Vedantham, Priyadarshini Jaishankar, Masaaki Sokabe, Aaron S Mendez, Billy W Newton, Edward L Tang, Erik Verschueren, Jeffrey R Johnson, Nevan J Krogan, Christopher S Fraser, Jonathan S Weissman, Adam R Renslo, Peter Walter
Published 2015-04-01

Pharmacological brake-release of mRNA translation enhances cognitive memory

by Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara M Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, Karim Nader, Michelle R Arkin, Adam R Renslo, Nahum Sonenberg, Peter Walter
Published 2013-05-01

A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

by Gha-Hyun J Kim, Han Mo, Harrison Liu, Zhihao Wu, Steven Chen, Jiashun Zheng, Xiang Zhao, Daryl Nucum, James Shortland, Longping Peng, Mannuel Elepano, Benjamin Tang, Steven Olson, Nick Paras, Hao Li, Adam R Renslo, Michelle R Arkin, Bo Huang, Bingwei Lu, Marina Sirota, Su Guo
Published 2021-09-01

Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

by Jonathan W. Choy, Clifford Bryant, Claudia M. Calvet, Patricia S. Doyle, Shamila S. Gunatilleke, Siegfried S. F. Leung, Kenny K. H. Ang, Steven Chen, Jiri Gut, Juan A. Oses-Prieto, Jonathan B. Johnston, Michelle R. Arkin, Alma L. Burlingame, Jack Taunton, Matthew P. Jacobson, James M. McKerrow, Larissa M. Podust, Adam R. Renslo
Published 2013-01-01

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.

by Christopher E Heise, Jeremy Murray, Katherine E Augustyn, Brandon Bravo, Preeti Chugha, Frederick Cohen, Anthony M Giannetti, Paul Gibbons, Rami N Hannoush, Brian R Hearn, Priyadarshini Jaishankar, Cuong Q Ly, Kinjalkumar Shah, Karen Stanger, Micah Steffek, Yinyan Tang, Xianrui Zhao, Joseph W Lewcock, Adam R Renslo, John Flygare, Michelle R Arkin
Published 2012-01-01