Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

by Mable Lam, Scot A Marsters, Avi Ashkenazi, Peter Walter
Published 2020-01-01

MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation

by Tom T. Chen, Ellen Filvaroff, Jing Peng, Scot Marsters, Adrian Jubb, Hartmut Koeppen, Mark Merchant, Avi Ashkenazi
Published 2015-05-01

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

by Anna Shemorry, Jonathan M Harnoss, Ofer Guttman, Scot A Marsters, László G Kőműves, David A Lawrence, Avi Ashkenazi
Published 2019-08-01

Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans

by Mor Levi-Ferber, Rewayd Shalash, Adrien Le-Thomas, Yehuda Salzberg, Maor Shurgi, Jennifer IC Benichou, Avi Ashkenazi, Sivan Henis-Korenblit
Published 2021-09-01

Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival.

by Charles R Holst, Hani Bou-Reslan, Bryan B Gore, Karen Wong, Deanna Grant, Sreedevi Chalasani, Richard A Carano, Gretchen D Frantz, Marc Tessier-Lavigne, Brad Bolon, Dorothy M French, Avi Ashkenazi
Published 2007-06-01

Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models.

by Dorothy M French, Benjamin C Lin, Manping Wang, Camellia Adams, Theresa Shek, Kathy Hötzel, Brad Bolon, Ronald Ferrando, Craig Blackmore, Kurt Schroeder, Luis A Rodriguez, Maria Hristopoulos, Rayna Venook, Avi Ashkenazi, Luc R Desnoyers
Published 2012-01-01

Pharmacological brake-release of mRNA translation enhances cognitive memory

by Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara M Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, Karim Nader, Michelle R Arkin, Adam R Renslo, Nahum Sonenberg, Peter Walter
Published 2013-05-01

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

by Elena Ferri, Adrien Le Thomas, Heidi Ackerly Wallweber, Eric S. Day, Benjamin T. Walters, Susan E. Kaufman, Marie-Gabrielle Braun, Kevin R. Clark, Maureen H. Beresini, Kyle Mortara, Yung-Chia A. Chen, Breanna Canter, Wilson Phung, Peter S. Liu, Alfred Lammens, Avi Ashkenazi, Joachim Rudolph, Weiru Wang
Published 2020-12-01