Dysfunction of Cellular Proteostasis in Parkinson’s Disease

by Šárka Lehtonen, Šárka Lehtonen, Tuuli-Maria Sonninen, Sara Wojciechowski, Gundars Goldsteins, Jari Koistinaho, Jari Koistinaho
Published 2019-05-01

Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia

by Katrina Albert, Jonna Niskanen, Sara Kälvälä, Šárka Lehtonen
Published 2021-04-01

Blood–Brain Barrier and Neurodegenerative Diseases—Modeling with iPSC-Derived Brain Cells

by Ying-Chieh Wu, Tuuli-Maria Sonninen, Sanni Peltonen, Jari Koistinaho, Šárka Lehtonen
Published 2021-07-01

Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases

by Tuuli-Maria Sonninen, Gundars Goldsteins, Nihay Laham-Karam, Jari Koistinaho, Šárka Lehtonen
Published 2020-09-01

Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene

by Minna Oksanen, Ida Hyötyläinen, Jenni Voutilainen, Katja A. Puttonen, Riikka H. Hämäläinen, Caroline Graff, Šárka Lehtonen, Jari Koistinaho
Published 2018-08-01

Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Do Not Promote Functional Recovery of Pharmacologically Immunosuppressed Mice with Contusion Spinal...

by Yuriy Pomeshchik, Katja A. Puttonen, Iurii Kidin, Marika Ruponen, Sarka Lehtonen, Tarja Malm, Elisabet Åkesson, Outi Hovatta, Jari Koistinaho
Published 2015-09-01

Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease

by Šárka Lehtonen, Ida Höytyläinen, Jenni Voutilainen, Tuuli-Maria Sonninen, Johanna Kuusisto, Markku Laakso, Riikka H. Hämäläinen, Minna Oksanen, Jari Koistinaho
Published 2018-07-01

Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer’s...

by Taisia Rolova, Ying-Chieh Wu, Marja Koskuvi, Jenni Voutilainen, Tuuli-Maria Sonninen, Johanna Kuusisto, Markku Laakso, Riikka H. Hämäläinen, Jari Koistinaho, Šárka Lehtonen
Published 2020-10-01

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling

by Jussi T. Koivumäki, Nikolay Naumenko, Tomi Tuomainen, Jouni Takalo, Jouni Takalo, Minna Oksanen, Katja A. Puttonen, Šárka Lehtonen, Johanna Kuusisto, Markku Laakso, Jari Koistinaho, Pasi Tavi
Published 2018-02-01

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

by Paula Korhonen, Eveliina Pollari, Katja M. Kanninen, Ekaterina Savchenko, Šárka Lehtonen, Sara Wojciechowski, Yuriy Pomeshchik, Ludo Van Den Bosch, Gundars Goldsteins, Jari Koistinaho, Tarja Malm
Published 2019-06-01

Metabolic alterations in Parkinson’s disease astrocytes

by Tuuli-Maria Sonninen, Riikka H. Hämäläinen, Marja Koskuvi, Minna Oksanen, Anastasia Shakirzyanova, Sara Wojciechowski, Katja Puttonen, Nikolay Naumenko, Gundars Goldsteins, Nihay Laham-Karam, Marko Lehtonen, Pasi Tavi, Jari Koistinaho, Šárka Lehtonen
Published 2020-09-01

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

by Meike Hedwig Keuters, Velta Keksa-Goldsteine, Hiramani Dhungana, Mikko T. Huuskonen, Yuriy Pomeshchik, Ekaterina Savchenko, Paula K. Korhonen, Yajuvinder Singh, Sara Wojciechowski, Šárka Lehtonen, Katja M. Kanninen, Tarja Malm, Jouni Sirviö, Anu Muona, Milla Koistinaho, Gundars Goldsteins, Jari Koistinaho
Published 2021-02-01

Sex-specific transcriptional and proteomic signatures in schizophrenia

by Jari Tiihonen, Marja Koskuvi, Markus Storvik, Ida Hyötyläinen, Yanyan Gao, Katja A. Puttonen, Raisa Giniatullina, Ekaterina Poguzhelskaya, Ilkka Ojansuu, Olli Vaurio, Tyrone D. Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Lesley Cheng, Andrew F. Hill, Markku Lähteenvuo, Jussi Tohka, Rashid Giniatullin, Šárka Lehtonen, Jari Koistinaho
Published 2019-09-01