TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS

by Kathleen M Cunningham, Kirstin Maulding, Kai Ruan, Mumine Senturk, Jonathan C Grima, Hyun Sung, Zhongyuan Zuo, Helen Song, Junli Gao, Sandeep Dubey, Jeffrey D Rothstein, Ke Zhang, Hugo J Bellen, Thomas E Lloyd
Published 2020-12-01

Spike-timing-dependent ensemble encoding by non-classically responsive cortical neurons

by Michele N Insanally, Ioana Carcea, Rachel E Field, Chris C Rodgers, Brian DePasquale, Kanaka Rajan, Michael R DeWeese, Badr F Albanna, Robert C Froemke
Published 2019-01-01

Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

by Gavin J Knott, Brady F Cress, Jun-Jie Liu, Brittney W Thornton, Rachel J Lew, Basem Al-Shayeb, Daniel J Rosenberg, Michal Hammel, Benjamin A Adler, Marco J Lobba, Michael Xu, Adam P Arkin, Christof Fellmann, Jennifer A Doudna
Published 2019-08-01

Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

by Haley Hieronymus, Rajmohan Murali, Amy Tin, Kamlesh Yadav, Wassim Abida, Henrik Moller, Daniel Berney, Howard Scher, Brett Carver, Peter Scardino, Nikolaus Schultz, Barry Taylor, Andrew Vickers, Jack Cuzick, Charles L Sawyers
Published 2018-09-01

cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool

by Vladimir Camarena, David W Sant, Tyler C Huff, Sushmita Mustafi, Ryan K Muir, Allegra T Aron, Christopher J Chang, Adam R Renslo, Paula V Monje, Gaofeng Wang
Published 2017-12-01

Biogenesis of phased siRNAs on membrane-bound polysomes in Arabidopsis

by Shengben Li, Brandon Le, Xuan Ma, Shaofang Li, Chenjiang You, Yu Yu, Bailong Zhang, Lin Liu, Lei Gao, Ting Shi, Yonghui Zhao, Beixin Mo, Xiaofeng Cao, Xuemei Chen
Published 2016-12-01

Transient Decrease of Circulating and Tissular Dendritic Cells in Patients With Mycobacterial Disease and With Partial Dominant IFNγR1 Deficiency

by Laura Dotta, Donatella Vairo, Mauro Giacomelli, Daniele Moratto, Nicola Tamassia, William Vermi, Silvia Lonardi, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jacinta Bustamante, Jacinta Bustamante, Jacinta Bustamante, Jacinta Bustamante, Silvia Giliani, Raffaele Badolato
Published 2020-06-01

Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections

by Larissa B. Thackray, Scott A. Handley, Matthew J. Gorman, Subhajit Poddar, Prachi Bagadia, Carlos G. Briseño, Derek J. Theisen, Qing Tan, Barry L. Hykes, Jr., Hueylie Lin, Tiffany M. Lucas, Chandni Desai, Jeffrey I. Gordon, Kenneth M. Murphy, Herbert W. Virgin, Michael S. Diamond
Published 2018-03-01

Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment

by Vishnu Dileep, Korey A. Wilson, Claire Marchal, Xiaowen Lyu, Peiyao A. Zhao, Ben Li, Axel Poulet, Daniel A. Bartlett, Juan Carlos Rivera-Mulia, Zhaohui S. Qin, Allan J. Robins, Thomas C. Schulz, Michael J. Kulik, Rachel Patton McCord, Job Dekker, Stephen Dalton, Victor G. Corces, David M. Gilbert
Published 2019-07-01

IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature

by Karina Gobin, Mary Hintermeyer, Bertrand Boisson, Bertrand Boisson, Bertrand Boisson, Maya Chrabieh, Maya Chrabieh, Pegah Ghandil, Pegah Ghandil, Pegah Ghandil, Pegah Ghandil, Anne Puel, Anne Puel, Capucine Picard, Capucine Picard, Capucine Picard, Capucine Picard, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, John Routes, James Verbsky
Published 2017-04-01

Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

by Jason G. Anderson, Giorgio Ramadori, Rafael M. Ioris, Mirco Galiè, Eric D. Berglund, Katie C. Coate, Teppei Fujikawa, Stefania Pucciarelli, Benedetta Moreschini, Augusto Amici, Cristina Andreani, Roberto Coppari
Published 2015-11-01

ERRγ Preserves Brown Fat Innate Thermogenic Activity

by Maryam Ahmadian, Sihao Liu, Shannon M. Reilly, Nasun Hah, Weiwei Fan, Eiji Yoshihara, Pooja Jha, C. Daniel De Magalhaes Filho, Sandra Jacinto, Andrew V. Gomez, Yang Dai, Ruth T. Yu, Christopher Liddle, Annette R. Atkins, Johan Auwerx, Alan R. Saltiel, Michael Downes, Ronald M. Evans
Published 2018-03-01

Loss of TARBP2 Drives the Progression of Hepatocellular Carcinoma via miR-145-SERPINE1 Axis

by Li-Man Li, Chang Chen, Ruo-Xi Ran, Jing-Tao Huang, Jing-Tao Huang, Hui-Lung Sun, Chang Zeng, Zhou Zhang, Wei Zhang, Wei Zhang, Song-Mei Liu, Song-Mei Liu
Published 2021-06-01

Intended consequences statement

by Ryan Phelan, Bridget Baumgartner, Stewart Brand, Evelyn Brister, Stanley W. Burgiel, R. Alta Charo, Isabelle Coche, Al Cofrancesco, Jason A. Delborne, Owain Edwards, Joshua P. Fisher, Martin Gaywood, Doria R. Gordon, Gregg Howald, Margaret E. Hunter, Peter Kareiva, Aditi Mankad, Michelle Marvier, Katherine Moseby, Andrew E. Newhouse, Ben J. Novak, Gerry Ohrstrom, Steven Olson, Megan J. Palmer, Stephen Palumbi, Neil Patterson Jr., Miguel Pedrono, Francisco Pelegri, Yasha Rohwer, Oliver A. Ryder, J. Royden Saah, Robert M. Scheller, Philip J. Seddon, H. Bradley Shaffer, Beth Shapiro, Mike Sweeney, Mark R. Tercek, Delphine Thizy, Whitney Tilt, Michele Weber, Renee D. Wegrzyn, Bruce Whitelaw, Matthew Winkler, Josh Wodak, Mark Zimring, Paul Robbins
Published 2021-04-01

Epileptiform activity and behavioral arrests in mice overexpressing the calcium channel subunit α2δ-1

by Leonardo C. Faria, Feng Gu, Isabel Parada, Ben Barres, Z. David Luo, David A. Prince
Published 2017-06-01

Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates

by Amanda Klein, Hans Jürgen Solinski, Nathalie M Malewicz, Hada Fong-ha Ieong, Elizabeth I Sypek, Steven G Shimada, Timothy V Hartke, Matthew Wooten, Gang Wu, Xinzhong Dong, Mark A Hoon, Robert H LaMotte, Matthias Ringkamp
Published 2021-04-01

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

by Mohammad Abu-Odeh, Yuan Zhang, Shannon M. Reilly, Nima Ebadat, Omer Keinan, Joseph M. Valentine, Maziar Hafezi-Bakhtiari, Hadeel Ashayer, Lana Mamoun, Xin Zhou, Jin Zhang, Ruth T. Yu, Yang Dai, Christopher Liddle, Michael Downes, Ronald M. Evans, Steven A. Kliewer, David J. Mangelsdorf, Alan R. Saltiel
Published 2021-06-01

Ancient mitochondrial genomes from the Argentinian Pampas inform the early peopling of the Southern Cone of South America

by Xavier Roca-Rada, Gustavo Politis, Pablo G. Messineo, Nahuel Scheifler, Clara Scabuzzo, Mariela González, Kelly M. Harkins, David Reich, Yassine Souilmi, João C. Teixeira, Bastien Llamas, Lars Fehren-Schmitz
Published 2021-06-01

Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome

by Brahim Belaid, Brahim Belaid, Lydia Lamara Mahammed, Lydia Lamara Mahammed, Aida Mohand Oussaid, Aida Mohand Oussaid, Melanie Migaud, Melanie Migaud, Yasmine Khadri, Jean Laurent Casanova, Jean Laurent Casanova, Jean Laurent Casanova, Jean Laurent Casanova, Anne Puel, Anne Puel, Anne Puel, Nafissa Ben Halla, Nafissa Ben Halla, Reda Djidjik, Reda Djidjik
Published 2021-06-01